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Article
Intervening in the Premonitory Phase to Prevent Migraine: Prospects for Pharmacotherapy
Migraine is a common brain condition characterised by disabling attacks of headache with sensory sensitivities. Despite increasing understanding of migraine neurobiology and the impacts of this on therapeutic ...
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Article
Open AccessMedication-overuse headache: a narrative review
Medication-overuse headache (MOH), which potentially involves 1–2% of the population, is defined as a headache, on ≥ 15 days a month affected, along with overuse of one or other acute attack medications. MOH p...
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Article
Open AccessAn economic evaluation of eptinezumab for the preventive treatment of migraine in the UK, with consideration for natural history and work productivity
Migraine is a highly prevalent neurological disease with a substantial societal burden due to lost productivity. From a societal perspective, we assessed the cost-effectiveness of eptinezumab for the preventiv...
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Article
Open AccessStructural equation modeling for identifying the drivers of health-related quality of life improvement experienced by patients with migraine receiving eptinezumab
As new migraine therapies emerge, it is crucial for measures to capture the complexities of health-related quality of life (HRQoL) improvement beyond improvements in monthly migraine day (MMD) reduction. Inves...
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Article
Open AccessComparing the Efficacy and Safety of Galcanezumab Versus Rimegepant for Prevention of Episodic Migraine: Results from a Randomized, Controlled Clinical Trial
There have been no prior trials directly comparing the efficacy of different calcitonin gene-related peptide (CGRP) antagonists for migraine prevention. Reported are the results from the first head-to-head stu...
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Article
Management of cervical CSF-venous fistula causing acute cognitive impairment and coma
CSF-venous fistulas (CVFs) are increasingly recognised as a cause of spontaneous intracranial hypotension. They may present atypically including with brain sagging pseudo-dementia. Cervical CVFs are rare and t...
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Article
Open AccessWho cares about migraine? Pathways and hurdles in the European region - access to care III
Migraine is a highly prevalent primary headache disorder and a leading cause of disability. Difficulties in access to care during diagnostic and therapeutic journey contribute to the disease burden. Several ta...
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Article
Open AccessNeuroimaging in the pre-ictal or premonitory phase of migraine: a narrative review
The premonitory phase, or prodrome, of migraine, provides valuable opportunities to study attack initiation and for treating the attack before headache starts. Much that has been learned about this phase in re...
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Article
Open AccessMigraine: from pathophysiology to treatment
Migraine is an extremely disabling, common neurological disorder characterized by a complex neurobiology, involving a series of central and peripheral nervous system areas and networks. A growing increase in t...
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Article
Open AccessRevisiting dose-finding of monoclonal antibodies in migraine
Migraine is a debilitating disorder, and while the introduction of monoclonal antibodies (mAbs) has led to efficacious and tolerable responses, a substantial number of patients are so-called “non-responders”. ...
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Article
Open AccessMedium-term real-world data for erenumab in 177 treatment resistant or difficult to treat chronic migraine patients: persistence and patient reported outcome measures after 17–30 months
Many migraine patients do not respond adequately to conventional preventive treatments and are therefore described as treatment/medically resistant or difficult to treat cases. Calcitonin gene-related peptide ...
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Chapter
Patient-Reported Outcomes in Migraine and Cluster Headache
Primary headache disorders, particularly migraine and cluster headache, impose a profound burden upon the patient population. Given these disorders inflict significant pain and disability, obtaining informatio...
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Article
Open AccessEffects of eptinezumab on self-reported work productivity in adults with migraine and prior preventive treatment failure in the randomized, double-blind, placebo-controlled DELIVER study
The multinational phase 3b DELIVER trial was designed to evaluate the efficacy and safety of eptinezumab for migraine prevention in patients with prior preventive treatment failures across 17 countries. In the...
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Article
Headache After Vaccination: An Update on Recent Clinical Trials and Real-World Reporting
The aim of this review is to characterize headache as a vaccine adverse event (VAE) in clinical trials.
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Article
Open AccessNew Oral Drugs for Migraine
Migraine is a common and disabling neurological disorder, with several manifestations, of which pain is just one. Despite its worldwide prevalence, there remains a paucity of targeted and effective treatments ...
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Article
Open AccessRestricted truncal sagittal movements of rapid eye movement behaviour disorder
Unlike sleep-walkers, patients with rapid-eye-movement-behaviour disorder (RBD) rarely leave the bed during the re-enactment of their dreams. RBD movements may be independent of spatial co-ordinates of the ‘ou...
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Article
Open AccessA Prospective Real-World Study Exploring Associations Between Passively Collected Tracker Data and Headache Burden Among Individuals with Tension-Type Headache and Migraine
Prevalence and burden of headache disorders in real-world settings is relatively unstudied. We explored the associations between passively collected activity data, headache burden, and quality of life in heada...
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Article
Open AccessCranial autonomic symptoms: prevalence, phenotype and laterality in migraine and two potentially new symptoms
Whilst cranial autonomic symptoms (CAS) are typically associated with trigeminal autonomic cephalalgias (TAC’s), they have also been reported in migraine. Identification and understanding of these symptoms in ...
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Article
Migraine
Migraine is a common, chronic, disorder that is typically characterized by recurrent disabling attacks of headache and accompanying symptoms, including aura. The aetiology is multifactorial with rare monogenic...
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Reference Work Entry In depth
Migraine
Migraine is a common, disabling disorder in the central nervous system. Migraine is a disorder that has three key features: the tendency is largely inherited, the sufferer is sensitive to exogenous and endogen...
