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Article
Loss of genes on chromosome 22 in tumorigenesis of human acoustic neuroma
The application of recombinant DNA techniques has identified two fundamental mechanisms of tumorigenesis in man. The first involves a qualitative or quantitative change in an oncogene (see ref. 1 for review). ...
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Article
Genetic linkage of bilateral acoustic neurofibromatosis to a DNA marker on chromosome 22
Bilateral acoustic neurofibromatosis (BANF) is a severe autosomal dominant disorder involving development of multiple tumours of the nervous system including meningiomas, gliomas, neurofibromas and particular...
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Article
Photodynamic therapy is potentiated by Co60 and intratumoral injection of hematoporphyrin derivative
Hematoporphyrin derivative injected directly into a subcutaneous rat glioma resulted in a significant greater tumor growth inhibition than hematoporphyrin derivative injected parenterally upon stimulation by l...
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Chapter
Genetic Alterations of Nervous System Tumors
The last decade has witnessed revolutionary advances in our understanding of the basic molecular changes associated with carcinogenesis in general and with nervous system tumorigenesis in particular. This repo...
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Article
Growth of human acoustic neuromas, neurofibromas and schwannomas in the subrenal capsule and sciatic nerve of the nude mouse
To develop a reproducible in vivo model for the growth of human acoustic neuromas and neurofibromas, we implanted tumor specimens (6 acoustic neuromas; 4 neurofibromas; 3 schwannomas arising in skin and soft tiss...
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Chapter
Virus-Mediated Genetic Treatment of Rodent Gliomas
The most common primary central nervous system neoplasm in adults is the malignant glioma. Approximately 5,000 new cases are diagnosed annually in the United States. This tumor has proven to be extremely refra...
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Article
Inhibition of angiogenesis and growth of human non-malignant and malignant meningiomas by TNP-470
Meningiomas are relatively common (22%) vascular brain tumors. 3–11% of meningiomas are malignant, and defy currently available therapy. Inhibition of neovascularization is one potential strategy for treating ...
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Article
Attenuated multi–mutated herpes simplex virus–1 for the treatment of malignant gliomas
We have created a double mutant of the herpes simplex virus (HSV) type 1 (termed G207) with favourable properties for treating human malignant brain tumours: replication–competence in glioblastoma cells (and o...
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Chapter and Conference Paper
Experimental Therapy for Malignant Brain Tumors Using Genetically Engineered Herpes Simplex Virus Type 1
We are exploring a novel experimental treatment for malignant brain tumors utilizing a genetically engineered, attenuated, replication-competent herpes simplex virus type 1 (HSV-1). Our previous studies demons...
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Article
Frequent loss of chromosome 14 in atypical and malignant meningioma: identification of a putative `tumor progression' locus
Formation of meningiomas has been associated with the loss of genetic material on chromosome 22. To approach the additional chromosomal events that underlie progression of these tumors to malignancy, we have e...
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Article
Act locally, think globally
Locally growing malignant brain tumors provide a reasonable starting point for develo** targeted strategies of anti-cancer therapy (pages 1354–1368).
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Article
Craniofacial Hemangiopericytoma Associated with Oncogenic Osteomalacia: Case Report
A craniofacial hemangiopericytoma associated with oncogenic osteomalacia is described and the literature is reviewed. A 46 year-old male with multiple fractures and hypophosphatemia was found to have a craniof...
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Article
Evaluation of ganciclovir-mediated enhancement of the antitumoral effect in oncolytic, multimutated herpes simplex virus type 1 (G207) therapy of brain tumors
G207 is a multimutated, conditionally replicating herpes simplex virus type 1 (HSV-1) that retains an intact viral thymidine kinase (HSV-tk) gene. The virus exhibits oncolytic activity in various tumors and is...
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Article
The angiogenic factor midkine is aberrantly expressed in NF1-deficient Schwann cells and is a mitogen for neurofibroma-derived cells
Loss of the tumor suppressor gene NF1 in neurofibromatosis type 1 (NF1) contributes to the development of a variety of tumors, including malignant peripheral nerve sheath tumors (MPNST) and benign neurofibromas. ...
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Article
Replication-selective virotherapy for cancer: Biological principles, risk management and future directions
In the search for novel cancer therapies that can be used in conjunction with existing treatments, one promising area of research is the use of viral vectors and whole viruses. This review describes the underl...
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Article
Differential modulation of malignant peripheral nerve sheath tumor growth by omega-3 and omega-6 fatty acids
Neurofibromatosis type 1 (NF1) is a common genetic disorder of the nervous system resulting in neurofibromas and malignant peripheral nerve sheath tumors (MPNST). In this study, we report the modulation of mur...
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Article
Oncolytic viral therapies – the clinical experience
It has been 9 years since the beginning of the first clinical trial in which an oncolytic virus was administered to cancer patients. Since then, oncolytic viruses from five different species have been taken to...
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Article
Open AccessFlip-Flop HSV-BAC: bacterial artificial chromosome based system for rapid generation of recombinant herpes simplex virus vectors using two independent site-specific recombinases
Oncolytic herpes simplex virus (HSV) vectors that specifically replicate in and kill tumor cells sparing normal cells are a promising cancer therapy. Traditionally, recombinant HSV vectors have been generated ...
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Article
The added value of concurrently administered temozolomide versus adjuvant temozolomide alone in newly diagnosed glioblastoma
Purpose Temozolomide (TMZ), given concurrently with radiotherapy (RT) and as adjuvant monotherapy afterwards, has led to improved survival in glioblastoma multiforme (GBM). However, it is unclear whether its prim...
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Article
Open AccessIdentification of diagnostic serum protein profiles of glioblastoma patients
Diagnosis of a glioblastoma (GBM) is triggered by the onset of symptoms and is based on cerebral imaging and histological examination. Serum-based biomarkers may support detection of GBM. Here, we explored ser...
