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    The angiogenic factor midkine is aberrantly expressed in NF1-deficient Schwann cells and is a mitogen for neurofibroma-derived cells

    Loss of the tumor suppressor gene NF1 in neurofibromatosis type 1 (NF1) contributes to the development of a variety of tumors, including malignant peripheral nerve sheath tumors (MPNST) and benign neurofibromas. ...

    George A Mashour, Nancy Ratner, Galam A Khan, Huey-Ling Wang, Robert L Martuza… in Oncogene (2001)