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  1. Article

    Open Access

    Combination of the histone deacetylase inhibitor vorinostat with bevacizumab in patients with clear-cell renal cell carcinoma: a multicentre, single-arm phase I/II clinical trial

    Class II histone deacetylase (HDAC) inhibitors induce hypoxia-inducible factor-1 and -2α degradation and have antitumour effects in combination with vascular endothelial growth factor (VEGF) inhibitors. In this s...

    Roberto Pili, Glenn Liu, Sreenivasulu Chintala… in British Journal of Cancer (2017)

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    Article

    Phase II trial of fenretinide (NSC 374551) in patients with recurrent small cell lung cancer

    Background Alterations in retinoid signaling appear to be involved in the pathogenesis of small cell lung cancer (SCLC). Fenretinide [N-(4-hydroxyphenyl)retinamide], a synthetic retinoid, inhibits the growth of S...

    Bryan J. Schneider, Francis P. Worden, Shirish M. Gadgeel… in Investigational New Drugs (2009)

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    Article

    Phase II trial of fenretinide in advanced renal carcinoma

    Purpose: Fenretinide, a synthetic form of retinoid, induced apoptosis even in chemotherapy resistant cell lines. A phase II study was hence conducted to evaluate toxicity and efficacy of fenretinide in metastatic...

    Ulka Vaishampayan, Lance K. Heilbrun, Ralph E. Parchment… in Investigational New Drugs (2005)

  4. Article

    Replication-selective virotherapy for cancer: Biological principles, risk management and future directions

    In the search for novel cancer therapies that can be used in conjunction with existing treatments, one promising area of research is the use of viral vectors and whole viruses. This review describes the underl...

    David Kirn, Robert L. Martuza, James Zwiebel in Nature Medicine (2001)

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  5. No Access

    Article

    p53Val135 temperature sensitive mutant suppresses growth of human breast cancer cells

    One common step in the malignant progression of a wide variety of human cancers seems to be inactivation of the p53 gene, via point mutation or deletion or both; or overexpression of mutated protein with domin...

    Daniel Eliyahu, Steve Evans, Neal Rosen… in Breast Cancer Research and Treatment (1994)