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Article
Open AccessB cell heterogeneity in human tuberculosis highlights compartment-specific phenotype and functional roles
B cells are important in tuberculosis (TB) immunity, but their role in the human lung is understudied. Here, we characterize B cells from lung tissue and matched blood of patients with TB and found they are de...
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Article
Open AccessPsychological flexibility as a mechanism of change in psilocybin-assisted therapy for major depression: results from an exploratory placebo-controlled trial
Several phase II studies have demonstrated that psilocybin-assisted therapy shows therapeutic potential across a spectrum of neuropsychiatric conditions, including major depressive disorder (MDD). However, the...
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Article
Open AccessImplementation of an antimicrobial stewardship program for urinary tract infections in long-term care facilities: a cluster-controlled intervention study
Widespread inappropriate use of antimicrobial substances drives resistance development worldwide. In long-term care facilities (LTCF), antibiotics are among the most frequently prescribed medications. More tha...
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Article
Open AccessSoluble urokinase plasminogen activator receptor (suPAR) in bronchoalveolar fluid and blood in critically ill patients—a prospective cohort study
Soluble urokinase plasminogen activator receptor (suPAR) is a biologically active protein and increased levels are associated with worse outcomes in critically ill patients. suPAR in bronchoalveolar fluid (BAL...
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Article
Open AccessPredictors for Prolonged Hospital Stay Solely to Complete Intravenous Antifungal Treatment in Patients with Candidemia: Results from the ECMM Candida III Multinational European Observational Cohort Study
To date, azoles represent the only viable option for oral treatment of invasive Candida infections, while rates of azole resistance among non-albicans Candida spp. continue to increase. The objective of this sub-...
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Article
Open AccessMycobacterium tuberculosis senses host Interferon-γ via the membrane protein MmpL10
Mycobacterium tuberculosis (Mtb) is one of the most successful human pathogens. Several cytokines are known to increase virulence of bacterial pathogens, leading us to investigate whether Interferon-γ (IFN-γ), a ...
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Article
Dark Mold Infections in Solid Organ Transplant Recipients
Solid organ transplant (SOT) recipients are a high-risk population for invasive fungal infections. While infections with black molds are rare in SOT recipients, they are important to consider since morbidity a...
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Article
Open AccessThe Antifungal Pipeline: Fosmanogepix, Ibrexafungerp, Olorofim, Opelconazole, and Rezafungin
The epidemiology of invasive fungal infections is changing, with new populations at risk and the emergence of resistance caused by the selective pressure from increased usage of antifungal agents in prophylaxi...
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Article
Open AccessAntifungal prophylaxis for prevention of COVID-19-associated pulmonary aspergillosis in critically ill patients: an observational study
Coronavirus disease 19 (COVID-19)-associated pulmonary aspergillosis (CAPA) emerged as important fungal complications in patients with COVID-19-associated severe acute respiratory failure (ARF). Whether mould ...
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Article
Open AccessConvalescent plasma therapy and mortality in COVID-19 patients admitted to the ICU: a prospective observational study
This study aimed to quantify the potential survival benefit of convalescent plasma therapy (CVP) in critically ill patients with acute respiratory failure related to coronavirus disease-2019 (COVID-19).
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Chapter
Heines Dialektik des Engagements
Zu Arbeit, Muße und Müßiggang hat Heine zeitlebens ein problematisches Verhältnis. Weder die frühzeitig ersehnte militärische noch die bürgerlich-kaufmännische noch die akademische Karriere glücken ihm, und de...
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Chapter
Nietzsches Umwertung der Arbeitsethik
Muße und Müßiggang waren für Nietzsches Leben, Denken und Schreiben von großer Bedeutung. Er beklagte als junger Basler Professor fehlende Muße, kannte als Altphilologe die langen Traditionen von scholê, otium...
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Chapter
Epilog
Der Gang der vorliegenden Untersuchung, die vielfach auf Benjamins Passagen-Arbeiten rekurrierte, schließt sich. Das Konvolut „m“, dessen kulturgeschichtliche Bedeutung bereits eingangs gewürdigt wurde, erlaubt e...
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Chapter
Von der aristokratischen Muße zum bürgerlichen Müßiggang. Vorspiel im Palais Royal
Direkt an einen der wichtigsten Sitze der französischen Könige, den Louvre, grenzt in nördlicher Richtung ein weiterer, monumentaler Palast an, der heute unter dem Namen Palais Royal bekannt ist. Dieser im Zen...
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Chapter
Müßiger Dandy und arbeitsamer Dichter: Baudelaires Widersprüche
Bekanntlich lag für Baudelaire die Modernität eines Künstlers darin, sich auf die eigene Gegenwart einzulassen. In den Blick kommen somit zeittypische soziokulturelle Phänomene und literarische Sujets, besonde...
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Chapter
Benjamins Unterscheidung zwischen Muße und Müßiggang
Wenig bekannt ist bisher die Bedeutung von Arbeit, Muße und Müßiggang für Benjamins Geschichte und Theorie der Moderne. Nahezu unbemerkt blieb sein ambitionierter Versuch, historisch und systematisch zwischen ...
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Chapter
Prolog
Die Geschichte der Moderne wurde oft als eine Geschichte der modernen Arbeitswelt – im Sinne der Ausdifferenzierung, Ökonomisierung, Professionalisierung und Beschleunigung – erzählt. Sie ist aber auch eine Ge...
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Article
Open AccessEfficacy of universal preoperative decolonization with Polyhexanide in primary joint arthroplasty on surgical site infections. A multicenter before-and after-study
Surgical site infections (SSI) are rare but severe complications after total joint arthroplasty (TJA). Decolonization measures prior to elective orthopedic surgeries have shown to reduce the risk of SSI with Stap...
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Article
Open AccessResponse to “COVID-19 in persons with haematological cancers”
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Article
The Mental Status Exam Through Video Clips of Simulated Psychiatric Patients: an Online Educational Resource
The Mental status exam (MSE) is a core component of psychiatric education. Innovative ways of teaching the MSE by making it “come alive” may prove useful in a wide range of curricular initiatives.
