38 Result(s)

Article

TGFβ biology in cancer progression and immunotherapy

TGFβ signalling has key roles in cancer progression: most carcinoma cells have inactivated their epithelial antiproliferative response and benefit from increased TGFβ expression and autocrine TGFβ signalling t...

Rik Derynck, Shannon J. Turley, Rosemary J. Akhurst in Nature Reviews Clinical Oncology (2021)

Protocol

Regulation of TGF-β Receptors

In cells responding to extracellular polypeptide ligands, regulatory mechanisms at the level of cell surface receptors are increasingly seen to define the nature of the ligand-induced signaling responses. Proc...

Erine H. Budi, Jian Xu, Rik Derynck in TGF-β Signaling (2016)

Article

Molecular mechanisms of epithelial–mesenchymal transition

Article

Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells

Much work remains to be done to understand the ‘black box’ of reprogramming, which involves changes in the expression of thousands of genes. Subramanyam et al. identify microRNAs that promote human cell reprogram...

Deepa Subramanyam, Samy Lamouille, Robert L Judson, Jason Y Liu… in Nature Biotechnology (2011)

Article

The type I TGF-β receptor is covalently modified and regulated by sumoylation

Post-translational sumoylation, the covalent attachment of a small ubiquitin-like modifier (SUMO), regulates the functions of proteins engaged in diverse processes. Often associated with nuclear and perinuclea...

Jong Seok Kang, Elise F. Saunier, Rosemary J. Akhurst, Rik Derynck in Nature Cell Biology (2008)

Article

Differentiation plasticity regulated by TGF-β family proteins in development and disease

During development, stem and progenitor cells gradually commit to differentiation pathways. Cell fate decisions are regulated by differentiation factors, which activate transcription programmes that specify li...

Rik Derynck, Rosemary J. Akhurst in Nature Cell Biology (2007)

Chapter

Smads In Mesenchymal Differentiation

Transforming growth factor-β (TGF-β) family members play key roles in development through their regulatory roles in cell and tissue differentiation. Among the differentiation lineages, mesenchymal tissue diffe...

Rik Derynck, Lisa Choy, Tamara Alliston in Smad Signal Transduction (2006)

Article

Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation

IRF-3, a member of the interferon regulatory factor (IRF) family of transcription factors, functions as a molecular switch for antiviral activity. IRF-3 uses an autoinhibitory mechanism to suppress its transac...

Bin Y Qin, Cheng Liu, Suvana S Lam, Hema Srinath… in Nature Structural & Molecular Biology (2003)

Article

Smad-dependent and Smad-independent pathways in TGF-β family signalling

Transforming growth factor-β (TGF-β) proteins regulate cell function, and have key roles in development and carcinogenesis. The intracellular effectors of TGF-β signalling, the Smad proteins, are activated by ...

Rik Derynck, Ying E. Zhang in Nature (2003)

Article

Interfering with bone remodelling

As they mature, bone-resorbing cells trigger the production of their own 'off-switch' — the interferon-β protein — to prevent the runaway bone loss that is seen in diseases such as osteoporosis.

Tamara Alliston, Rik Derynck in Nature (2002)

Article

TGF-β signaling in tumor suppression and cancer progression

Epithelial and hematopoietic cells have a high turnover and their progenitor cells divide continuously, making them prime targets for genetic and epigenetic changes that lead to cell transformation and tumorig...

Rik Derynck, Rosemary J. Akhurst, Allan Balmain in Nature Genetics (2001)

Protocol

Mammalian Two-Hybrid Assays

Mammalian two-hybrid assays are used to analyze protein-protein interactions in transiently transfected mammalian cells. The concepts and principles that form the basis for mammalian two-hybrid assays are esse...

**n-Hua Feng, Rik Derynck in Two-Hybrid Systems (2001)

Article

Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure

Craniofacial malformations are among the most frequent congenital birth defects in humans; cleft palate, that is inadequate fusion of the palatal shelves, occurs with an annual incidence of 1 in 700 to 1 in 1,...

Päivi J. Miettinen, Jennie R. Chin, Lillian Shum, Harold C. Slavkin… in Nature Genetics (1999)