18 Result(s)

Article

TGFβ biology in cancer progression and immunotherapy

TGFβ signalling has key roles in cancer progression: most carcinoma cells have inactivated their epithelial antiproliferative response and benefit from increased TGFβ expression and autocrine TGFβ signalling t...

Rik Derynck, Shannon J. Turley, Rosemary J. Akhurst in Nature Reviews Clinical Oncology (2021)

Article

Targeting the TGFβ signalling pathway in disease

Article

The paradoxical TGF-β vasculopathies

Two new studies show that haploinsufficiency for TGFB2 causes a familial syndrome of thoracic aortic aneurysms and dissections with other clinical features that overlap the Marfan, Loeys-Dietz spectrum of syndrom...

Rosemary J. Akhurst in Nature Genetics (2012)

Article

Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia

Hereditary haemorrhagic telangiectasia (HTT) is a vascular dysplasia syndrome caused by mutations in transforming growth factor-β/bone morphogenetic protein pathway genes, ENG and ACVRL1. HTT shows considerable v...

Michael Benzinou, Frederic F. Clermont, Tom G.W. Letteboer… in Nature Communications (2012)

Article

Taking thalidomide out of rehab

Thalidomide, a drug reviled in the 1960s for its teratogenic effects, has been revived in recent years for cancer and leprosy therapy. A study now finds another use for this drug in vascular disease, providing...

Rosemary J Akhurst in Nature Medicine (2010)

Article

The type I TGF-β receptor is covalently modified and regulated by sumoylation

Post-translational sumoylation, the covalent attachment of a small ubiquitin-like modifier (SUMO), regulates the functions of proteins engaged in diverse processes. Often associated with nuclear and perinuclea...

Jong Seok Kang, Elise F. Saunier, Rosemary J. Akhurst, Rik Derynck in Nature Cell Biology (2008)

Article

Differentiation plasticity regulated by TGF-β family proteins in development and disease

During development, stem and progenitor cells gradually commit to differentiation pathways. Cell fate decisions are regulated by differentiation factors, which activate transcription programmes that specify li...

Rik Derynck, Rosemary J. Akhurst in Nature Cell Biology (2007)

Article

A sweet link between TGFβ and vascular disease?

Mutations in SCL2A10, encoding a glucose transporter, result in arterial tortuosity syndrome, indicating a link between glucose metabolism and angiopathic changes. Intriguingly, some of the phenotypic effects of

Rosemary J Akhurst in Nature Genetics (2006)

Article

TGFβ signaling in health and disease

Inactivating mutations in TGFBR2, encoding the transforming growth factor-β (TGFβ) type 2 receptor, may account for up to 10% of cases of Marfan syndrome. This finding has implications for a wider spectrum of dis...

Rosemary J Akhurst in Nature Genetics (2004)

Article

Dangerous liaisons

The cells of multicellular organisms are highly communicative and so can strongly influence one another's behaviour. One line of communication is particularly important in kee** cell growth in check.

Allan Balmain, Rosemary J. Akhurst in Nature (2004)

Article

Metastasis is driven by sequential elevation of H-ras and Smad2 levels

Metastasis is a multistep process that involves local tumour invasion followed by dissemination to, and re-establishment at, distant sites. Here we show that during multistage tumorigenesis, discrete expressio...

Martin Oft, Rosemary J. Akhurst, Allan Balmain in Nature Cell Biology (2002)

Article

TGF-β signaling in tumor suppression and cancer progression

Epithelial and hematopoietic cells have a high turnover and their progenitor cells divide continuously, making them prime targets for genetic and epigenetic changes that lead to cell transformation and tumorig...

Rik Derynck, Rosemary J. Akhurst, Allan Balmain in Nature Genetics (2001)

Article

Map** of a major genetic modifier of embryonic lethality in TGFβ1 knockout mice

The transforming growth factor β1 (TGFβ1) signalling pathway^1,2 is important in embryogenesis³ and has been implicated in hereditary haemorrhagic telangiectasia (HHT)^4,5, atherosclerosis^6,7, tumorigenesis^8,9 and ...

Mortaza Bonyadi, Sarah A.B. Rusholme, Frances M. Cousins, Helen C. Su… in Nature Genetics (1997)

Chapter

Transforming growth factor ßs and cardiac development

Most studies of the action of growth factors on the cardiovascular system, and of the endogenous growth factor synthetic profiles of cardiac myocytes, endothelial cells and fibroblasts, have focused on tissues...

Rosemary J. Akhurst, Marion Dickson… in Growth Factors and the Cardiovascular Syst… (1993)

Article

Localized production of TGF-β mRNA in tumour promoter-stimulated mouse epidermis

Tumour promoters induce a wide spectrum of morphological and biochemical alterations when applied to mouse epidermis in vivo¹. These include the induction of RNA (ref. 2), DNA (refs 3, 4) and protein synthesis^5,...

Rosemary J. Akhurst, Frances Fee, Allan Balmaint in Nature (1988)