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Article
Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform
Caenorhabditis elegans is a valuable model organism in biomedical research that has led to major discoveries in the fields of neurodegeneration, cancer and aging. Because movement phenotypes are commonly used and...
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Protocol
C. elegans as a Model for Synucleinopathies and Other Neurodegenerative Diseases: Tools and Techniques
Caenorhabditis elegans is widely used to investigate biological processes related to health and disease. Multiple C. elegans models for human neurodegenerative diseases do exist, including those expressing human ...
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Article
Open AccessDiscovery and functional prioritization of Parkinson’s disease candidate genes from large-scale whole exome sequencing
Whole-exome sequencing (WES) has been successful in identifying genes that cause familial Parkinson’s disease (PD). However, until now this approach has not been deployed to study large cohorts of unrelated pa...
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Article
Open AccessIdentification of an evolutionary conserved structural loop that is required for the enzymatic and biological function of tryptophan 2,3-dioxygenase
The enzyme TDO (tryptophan 2,3-dioxygenase; TDO-2 in Caenorhabditis elegans) is a potential therapeutic target to cancer but is also thought to regulate proteotoxic events seen in the progression of neurodegenera...
