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  1. No Access

    Article

    Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform

    Caenorhabditis elegans is a valuable model organism in biomedical research that has led to major discoveries in the fields of neurodegeneration, cancer and aging. Because movement phenotypes are commonly used and...

    Mandy Koopman, Quentin Peter, Renée I. Seinstra, Michele Perni… in Nature Protocols (2020)

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    Protocol

    C. elegans as a Model for Synucleinopathies and Other Neurodegenerative Diseases: Tools and Techniques

    Caenorhabditis elegans is widely used to investigate biological processes related to health and disease. Multiple C. elegans models for human neurodegenerative diseases do exist, including those expressing human ...

    Mandy Koopman, Renée I. Seinstra, Ellen A. A. Nollen in Alpha-Synuclein (2019)

  3. Article

    Open Access

    Identification of an evolutionary conserved structural loop that is required for the enzymatic and biological function of tryptophan 2,3-dioxygenase

    The enzyme TDO (tryptophan 2,3-dioxygenase; TDO-2 in Caenorhabditis elegans) is a potential therapeutic target to cancer but is also thought to regulate proteotoxic events seen in the progression of neurodegenera...

    Helen Michels, Renée I. Seinstra, Joost C. M. Uitdehaag… in Scientific Reports (2016)

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    Article

    A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans

    Mitochondrial dysfunction is linked to a range of common disorders, including inherited metabolic diseases, diabetes and cancer. Here, Koopman et al. describe a protocol to study mitochondrial function in C. eleg...

    Mandy Koopman, Helen Michels, Beverley M Dancy, Rashmi Kamble… in Nature Protocols (2016)