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Article
Elicitin genes in Phytophthora infestans are clustered and interspersed with various transposon-like elements
Sequencing and annotation of a contiguous stretch of genomic DNA (112.3 kb) from the oomycete plant pathogen Phytophthora infestans revealed the order, spacing and genomic context of four members of the elicitin ...
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Article
Nonneutral GC3 and Retroelement Codon Mimicry in Phytophthora
Phytophthora is a genus entirely comprised of destructive plant pathogens. It belongs to the Stramenopila, a unique branch of eukaryotes, phylogenetically distinct from plants, animals, or fungi....
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Chapter
Functional Genomics and Bioinformatics of the Phytophthora sojae Soybean Interaction
Oomycete plant pathogens such as Phytophthora species and downy mildews cause destructive diseases in an enormous variety of crop plant species as well as forests and native ecosystems. These pathogens are most c...
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Article
Open AccessGenome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans
The genome of Phytophthora infestans, the pathogen that triggered the Irish potato famine in the nineteenth century, has been sequenced. It remains a devastating pathogen, with late blight destroying crops worth ...
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Protocol
Massively Parallel Sequencing Technology in Pathogenic Microbes
Next-Generation Sequencing (NGS) methods have revolutionized various aspects of genomics including transcriptome analysis. Digital expression analysis is all set to replace analog expression analysis that uses...
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Article
The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum
Jane Carlton and colleagues report the genome sequencing, de novo assembly and annotation of four Plasmodium vivax reference strains from diverse geographic locations. Their cross-species comparisons show that P....
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Open AccessChemogenomic profiling of Plasmodium falciparum as a tool to aid antimalarial drug discovery
The spread of Plasmodium falciparum multidrug resistance highlights the urgency to discover new targets and chemical scaffolds. Unfortunately, lack of experimentally validated functional information about most P....
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Article
Open AccessAncient human sialic acid variant restricts an emerging zoonotic malaria parasite
Plasmodium knowlesi is a zoonotic parasite transmitted from macaques causing malaria in humans in Southeast Asia. Plasmodium parasites bind to red blood cell (RBC) surface receptors, many of which are sialylated....
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Article
Open AccessPunctuated chromatin states regulate Plasmodium falciparum antigenic variation at the intron and 2 kb upstream regions
Understanding the regulation mechanism of var gene expression is crucial for explaining antigenic variation in Plasmodium falciparum. Recent work observed that while all var genes produce transcripts, only a few
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Article
Open AccessSubcellular and in-vivo Nano-Endoscopy
Analysis of individual cells at the subcellular level is important for understanding diseases and accelerating drug discovery. Nanoscale endoscopes allow minimally invasive probing of individual cell interiors...
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Article
Trinitrobenzene sulfonic acid-induced intestinal injury in neonatal mice activates transcriptional networks similar to those seen in human necrotizing enterocolitis
We have shown previously that enteral administration of 2, 4, 6-trinitrobenzene sulfonic acid in 10-d-old C57BL/6 pups produces an acute necrotizing enterocolitis with histopathological and inflammatory change...
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Article
Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony
Plasmodium parasites, the causative agents of malaria, have evolved a unique cell division cycle in the clinically relevant asexual blood stage of infection1. DNA replication commences approximately halfway throu...
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Erratum: Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony
Nature Microbiology 2, 17017 (2017); published online 17 February 2017; corrected 6 March 2017. In the version of this Letter originally published, the in-text citations to Supplementary Table 1 and Supplement...
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Article
Open AccessMalaria infected red blood cells release small regulatory RNAs through extracellular vesicles
The parasite Plasmodium falciparum causes the most severe form of malaria. Cell communication between parasites is an important mechanism to control population density and differentiation. The infected red blood ...
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Article
Open AccessA comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum
Malaria liver stages represent an ideal therapeutic target with a bottleneck in parasite load and reduced clinical symptoms; however, current in vitro pre-erythrocytic (PE) models for Plasmodium vivax and P. falc...
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Open AccessAuthor Correction: A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum
The original version of this Article contained an error in the spelling of Richard Thomson-Luque, which was incorrectly given as Richard Thomson Luque. This error has now been corrected in both the PDF and HTM...
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Article
Open AccessUnraveling the Plasmodium vivax sporozoite transcriptional journey from mosquito vector to human host
Malaria parasites transmitted by mosquito bite are remarkably efficient in establishing human infections. The infection process requires roughly 30 minutes and is highly complex as quiescent sporozoites inject...
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Article
Open AccessAltered expression of K13 disrupts DNA replication and repair in Plasmodium falciparum
Plasmodium falciparum exhibits resistance to the artemisinin component of the frontline antimalarial treatment Artemisinin-based Combination Therapy in South East Asia. Millions of lives will be at risk if artemi...
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Article
Open AccessGSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors
Mutant KRas is a significant driver of human oncogenesis and confers resistance to therapy, underscoring the need to develop approaches that disable mutant KRas-driven tumors. Because targeting KRas directly h...
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Article
Open AccessPlasmodium vivax readiness to transmit: implication for malaria eradication
The lack of a continuous long-term in vitro culture system for Plasmodium vivax severely limits our knowledge of pathophysiology of the most widespread malaria parasite. To gain direct understanding of P. vivax h...
