9 Result(s)
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Jonathan M. Goldberg
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Article
Open AccessCo-option of Plasmodium falciparum PP1 for egress from host erythrocytes
Asexual proliferation of the Plasmodium parasites that cause malaria follows a developmental program that alternates non-canonical intraerythrocytic replication with dissemination to new host cells. We carried ou...
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Open AccessQuantitative comparative analysis of human erythrocyte surface proteins between individuals from two genetically distinct populations
Red blood cells (RBCs) play a critical role in oxygen transport, and are the focus of important diseases including malaria and the haemoglobinopathies. Proteins at the RBC surface can determine susceptibility ...
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Erratum: Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony
Nature Microbiology 2, 17017 (2017); published online 17 February 2017; corrected 6 March 2017. In the version of this Letter originally published, the in-text citations to Supplementary Table 1 and Supplement...
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Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony
Plasmodium parasites, the causative agents of malaria, have evolved a unique cell division cycle in the clinically relevant asexual blood stage of infection1. DNA replication commences approximately halfway throu...
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Open AccessAncient human sialic acid variant restricts an emerging zoonotic malaria parasite
Plasmodium knowlesi is a zoonotic parasite transmitted from macaques causing malaria in humans in Southeast Asia. Plasmodium parasites bind to red blood cell (RBC) surface receptors, many of which are sialylated....
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Open AccessGenome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts
Pneumocystis jirovecii is a major cause of life-threatening pneumonia in immunosuppressed patients including transplant recipients and those with HIV/AIDS, yet surprisingly little is known about the biology of th...
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Open AccessContrasting host–pathogen interactions and genome evolution in two generalist and specialist microsporidian pathogens of mosquitoes
Obligate intracellular pathogens depend on their host for growth yet must also evade detection by host defenses. Here we investigate host adaptation in two Microsporidia, the specialist Edhazardia aedis and the g...
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Open AccessGenomics of Loa loa, a Wolbachia-free filarial parasite of humans
Thomas Nutman and colleagues report the draft genome of the filarial pathogen Loa loa, the African eyeworm. They also report coverage of two other filarial pathogens, Wuchereria bancrofti and Onchocerca volvulus....
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Article
The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum
Jane Carlton and colleagues report the genome sequencing, de novo assembly and annotation of four Plasmodium vivax reference strains from diverse geographic locations. Their cross-species comparisons show that P....
