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  1. No Access

    Article

    Hematological changes in neonatal mice with phlebotomy-induced anemia

    Anemia is a nearly universal diagnosis in preterm infants, caused by phlebotomy, and exacerbated by the underlying erythropoietic immaturity. Newborn infants are exposed to the unique stressor of fetal-to-neon...

    Yerin Chung, Suneetha Desiraju, Kopperuncholan Namachivayam… in Pediatric Research (2022)

  2. No Access

    Article

    Lyophilization of human amniotic fluid is feasible without affecting biological activity

    Fetal swallowing of human amniotic fluid (hAF) containing trophic factors (TFs) promotes gastrointestinal tract (GIT) development. Preterm birth interrupts hAF swallowing, which may increase the risk of necrot...

    John I. Coon, Sangeeta Jain, Krishna M. Sepuru, Yerin Chung… in Pediatric Research (2020)

  3. Article

    Open Access

    A murine neonatal model of necrotizing enterocolitis caused by anemia and red blood cell transfusions

    Necrotizing enterocolitis (NEC) is an idiopathic, inflammatory bowel necrosis of premature infants. Clinical studies have linked NEC with antecedent red blood cell (RBC) transfusions, but the underlying mechan...

    Krishnan MohanKumar, Kopperuncholan Namachivayam, Tan**g Song… in Nature Communications (2019)

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  4. Article

    Neonatal mice with necrotizing enterocolitis-like injury develop thrombocytopenia despite increased megakaryopoiesis

    Thrombocytopenia is frequently encountered in infants with necrotizing enterocolitis (NEC). To develop a preclinical model of NEC-related thrombocytopenia, we measured serial platelet counts in 10-d-old (P10) ...

    Kopperuncholan Namachivayam, Krishnan MohanKumar, Lalit Garg… in Pediatric Research (2017)

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  5. Article

    Trinitrobenzene sulfonic acid-induced intestinal injury in neonatal mice activates transcriptional networks similar to those seen in human necrotizing enterocolitis

    We have shown previously that enteral administration of 2, 4, 6-trinitrobenzene sulfonic acid in 10-d-old C57BL/6 pups produces an acute necrotizing enterocolitis with histopathological and inflammatory change...

    Krishnan MohanKumar, Kopperuncholan Namachivayam, Feng Cheng… in Pediatric Research (2017)

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  6. Article

    Smad7 interrupts TGF-β signaling in intestinal macrophages and promotes inflammatory activation of these cells during necrotizing enterocolitis

    Necrotizing enterocolitis (NEC) is an inflammatory bowel necrosis of premature infants. Based on our recent findings of increased Smad7 expression in surgically resected bowel affected by NEC, we hypothesized ...

    Krishnan MohanKumar, Kopperuncholan Namachivayam… in Pediatric Research (2016)

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  7. Article

    VEGF mRNA and protein concentrations in the develo** human eye

    Vascular endothelial growth factor (VEGF), a well-characterized regulator of angiogenesis, has been mechanistically implicated in retinal neovascularization and in the pathogenesis of retinopathy of prematurit...

    Irene T. Ma, Suzanne McConaghy, Kopperuncholan Namachivayam… in Pediatric Research (2015)

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  8. Article

    Editor’s Focus

    Irene T. Ma, Suzanne McConaghy, Kopperuncholan Namachivayam… in Pediatric Research (2015)

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