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  1. No Access

    Article

    Label-free detection and profiling of individual solution-phase molecules

    Most chemistry and biology occurs in solution, in which conformational dynamics and complexation underlie behaviour and function. Single-molecule techniques1 are uniquely suited to resolving molecular diversity a...

    Lisa-Maria Needham, Carlos Saavedra, Julia K. Rasch, Daniel Sole-Barber… in Nature (2024)

  2. Article

    Open Access

    A 2D chiral microcavity based on apparent circular dichroism

    Engineering asymmetric transmission between left-handed and right-handed circularly polarized light in planar Fabry–Pérot (FP) microcavities would enable a variety of chiral light-matter phenomena, with applic...

    Tzu-Ling Chen, Andrew Salij, Katherine A. Parrish, Julia K. Rasch… in Nature Communications (2024)

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  3. Article

    Open Access

    Theory predicts 2D chiral polaritons based on achiral Fabry–Pérot cavities using apparent circular dichroism

    Realizing polariton states with high levels of chirality offers exciting prospects for quantum information, sensing, and lasing applications. Such chirality must emanate from either the involved optical resona...

    Andrew H. Salij, Randall H. Goldsmith, Roel Tempelaar in Nature Communications (2024)

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  4. No Access

    Article

    cAMP binding to closed pacemaker ion channels is non-cooperative

    Electrical activity in the brain and heart depends on rhythmic generation of action potentials by pacemaker ion channels (HCN) whose activity is regulated by cAMP binding1. Previous work has uncovered evidence fo...

    David S. White, Sandipan Chowdhury, Vinay Idikuda, Ruohan Zhang… in Nature (2021)

  5. No Access

    Article

    Exploiting chemistry and molecular systems for quantum information science

    The power of chemistry to prepare new molecules and materials has driven the quest for new approaches to solve problems having global societal impact, such as in renewable energy, healthcare and information sc...

    Michael R. Wasielewski, Malcolm D. E. Forbes, Natia L. Frank… in Nature Reviews Chemistry (2020)

  6. No Access

    Article

    Optical microresonators as single-particle absorption spectrometers

    Optical measurements of nanoscale objects offer major insights into fundamental biological, material and photonic properties. In absorption spectroscopy, sensitivity limits applications at the nanoscale. Here,...

    Kevin D. Heylman, Niket Thakkar, Erik H. Horak, Steven C. Quillin… in Nature Photonics (2016)

  7. No Access

    Article

    Watching conformational- and photodynamics of single fluorescent proteins in solution

    Observing the dynamics of single biomolecules over prolonged time periods is difficult to achieve without significantly altering the molecule through immobilization. It can, however, be accomplished using the ...

    Randall H. Goldsmith, W. E. Moerner in Nature Chemistry (2010)

  8. No Access

    Chapter and Conference Paper

    Fabrication of a Nanoneedle Array

    We have developed a new fabrication method for building large arrays of needles with nanometer-size apertures. Because the process is entirely based on standard photolithographic techniques and conventional si...

    Herc P. Neves, Randall H. Goldsmith, Avery W. Degolyer… in Transducers ’01 Eurosensors XV (2001)