33 Result(s)

Article

5-Oxo-hexahydroquinoline and 5-oxo-tetrahydrocyclopentapyridine derivatives as promising antiproliferative agents with potential apoptosis-inducing capacity

Discovery of novel anticancer agents is of crucial importance to expand the therapeutic options for cancer patients. In this study, a series of 49 5-oxo-hexahydroquinoline and 5-oxo-tetrahydrocyclopentapyridin...

Sara Ranjbar, Mehdi Khoshneviszadeh, Marjan Tavakkoli, Ramin Miri… in Molecular Diversity (2022)

Article

The Effect of Platanus orientalis L. Distillate on Mouse Model of Allergic Rhinitis

Platanus orientalis L. has been used in traditional Persian medicine to treat allergic rhinitis. In this study, the therapeutic effects of P. orientalis L. distillate on allergic rhinitis mouse model were assesse...

Soheila Alyasin, Behjat Maneshian… in Iranian Journal of Science and Technology,… (2020)

Article

5-Oxo-hexahydroquinoline: an attractive scaffold with diverse biological activities

5-Oxo-hexahydroquinoline (5-oxo-HHQ) represents a biologically attractive fused heterocyclic core. Various synthetic analogs of 5-oxo-HHQ have been synthesized and assessed for different biological activities....

Sara Ranjbar, Najmeh Edraki, Omidreza Firuzi, Mehdi Khoshneviszadeh… in Molecular Diversity (2019)

Article

Structural Insight into Binding Mode of 9-Hydroxy Aristolochic Acid, Diclofenac and Indomethacin to PLA₂

Phospholipase A₂ (PLA₂) catalyzes the hydrolysis of phospholipids into arachidonic acid and lysophospholipids. Arachidonic acid is modified by cyclooxygenases into active compounds called eicosanoids that act as ...

Mohsen Ebrahimi, Omidreza Firuzi, Ramin Miri… in Interdisciplinary Sciences: Computational … (2018)

Article

Virtual screening of some heterocyclic structures toward novel antibacterial agents

Infectious diseases and their treatment are among the most important issues in global health and economy. Moreover, increasing prevalence of antibiotic-resistant pathogenic bacteria necessitates the considera...

Zahra S. Hosseini, Mohammad Reza Housaindokht… in Journal of the Iranian Chemical Society (2018)

Article

The antileishmanial effects of Lowsonia inermis and Cedrus libani on Leishmania major promastigotes: an in vitro study

Leishmaniasis is a parasitic disease caused by different species of protozoan parasites belonging to the genus Leishmania. In this study, Leishmania major (MRHO/IR/75/ER) promastigotes were cultured at 23–25 °C i...

Mohammad Hossein Motazedian, Fattaneh Mikaeili… in Journal of Parasitic Diseases (2017)

Article

2-Imino 2H-chromene and 2-(phenylimino) 2H-chromene 3-aryl carboxamide derivatives as novel cytotoxic agents: synthesis, biological assay, and molecular docking study

The inhibition of AKR₁B₁₀ has been recognized as a potential therapeutic approach to the treatment of various types of cancers. A novel series of compounds with imino-2H-chromen and phenylimino-2H-chromen scaffol...

Najmeh Edraki, Aida Iraji, Omidreza Firuzi… in Journal of the Iranian Chemical Society (2016)

Article

In vitro efficacy of ethanolic extract of Artemisia absinthium (Asteraceae) against Leishmania major L. using cell sensitivity and flow cytometry assays

Leishmaniasis is one of the most neglected human diseases with an estimated global burden ranking second in mortality and fourth in morbidity among the tropical infections. Chemotherapy involving the use of d...

Kourosh Azizi, Fatemeh Shahidi-Hakak, Qasem Asgari… in Journal of Parasitic Diseases (2016)

Article

Detailed atomistic molecular modeling of a potent type ΙΙ p38α inhibitor

The active site conservation among protein kinases makes it a real challenge to design selective inhibitors. In this regard, detailed understanding of structural features responsible for functional behavior of...

Seyed Ahmad Ebadi, Nima Razzaghi-Asl, Mehdi Khoshneviszadeh… in Structural Chemistry (2015)

Article

Inhibition of Alzheimer’s BACE-1 by 2,6-dialkyl-4-chromon-3-yl-1,4-dihydropyridine-3,5-dicarboxylates

Alzheimer’s disease is the most common cause of dementia in the elderly, and no disease-modifying therapy is yet available for this devastating pathology. Deposition of different physicochemical forms of amylo...

Nima Razzaghi-Asl, Neha Aggarwal, Smriti Srivastava… in Medicinal Chemistry Research (2015)

Article

Synthesis and cytotoxic activity of novel poly-substituted imidazo[2,1- \(c\) ][1,2,4]triazin-6-amines

A novel series of 3,4-diphenyl-7-(hetero)arylimidazo[2,1- \(c\) c ...

Tahmineh Akbarzadeh, Saeedeh Noushini, Somayeh Taban… in Molecular Diversity (2015)

Article

A validated dispersive liquid-liquid microextraction method for extraction of ochratoxin A from raisin samples

A method based on dispersive liquid-liquid microextraction (DLLME) was developed for the quantitative extraction of Ochratoxin A (OTA) from raisin samples. The influence of various parameters on the recovery o...

Rouhollah Karami-Osboo, Ramin Miri… in Journal of Food Science and Technology (2015)

Article

Inhibitors of Alzheimer’s BACE-1 with 3,5-bis-N-(aryl/heteroaryl) carbamoyl-4-aryl-1,4-dihydropyridine structure

β-site amyloid precursor protein cleaving enzyme (BACE-1) is a validated target for Alzheimer therapy due to its distinctive role in pathogenesis of AD. In the present contribution, a series of new 3,5-bis-N-(ary...

Ramin Miri, Omidreza Firuzi, Nima Razzaghi-Asl… in Archives of Pharmacal Research (2015)

Article

Molecular docking and quantum mechanical studies on biflavonoid structures as BACE-1 inhibitors

Beta-site amyloid precursor protein cleaving enzyme (BACE-1) is a well-known therapeutic target for Alzheimer disease (AD) due to its characteristic role in the pathogenesis of AD. Numerous researches have bee...

Nima Razzaghi-Asl, Saghi Sepehri, Ahmad Ebadi, Ramin Miri… in Structural Chemistry (2015)

Article

Cytotoxic activity assessment and c-Src tyrosine kinase docking simulation of thieno[2,3-b] pyridine-based derivatives

Thienopyridine derivatives possess various promising biological properties and particularly cytotoxic effect. In vitro cytotoxic activities of some thienopyridine analogous were evaluated by MTT reduction assa...

Ali Reza Nikkhoo, Ramin Miri, Nahid Arianpour… in Medicinal Chemistry Research (2014)

Article

Comparative hydrodistillation and headspace SPME-GC-MS analysis of volatile constituents of roots and shoots of Artemisia annua and Artemisia sieberi

Amir Reza Jassbi, Ramin Miri, Ian T. Baldwin in Chemistry of Natural Compounds (2014)

Article

Reversal of multidrug resistance in cancer cells by novel asymmetrical 1,4-dihydropyridines

Multidrug resistance (MDR) is an important obstacle that limits the efficacy of chemotherapy in many types of cancer. In this study, 14 novel asymmetrical DHPs possessing pyridyl alkyl carboxylate substitution...

Omidreza Firuzi, Katayoun Javidnia, Elham Mansourabadi… in Archives of Pharmacal Research (2013)