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Open AccessAggregation of type-2 diabetes, prediabetes, and metabolic syndrome in German couples
We aimed to examine the concordance of type-2 diabetes, prediabetes and the metabolic syndrome in couples. In cross-sectional analyses, we used data from 1173 couples with index persons from the Heinz Nixdorf ...
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Open AccessSynergism between coexisting eye diseases and sex in increasing the prevalence of the dry eye syndrome
The aim was to investigate prevalence of dry eye syndrome (DES) in a population-based sample in Germany. The association between coexisting eye diseases and DES was also of interest. We recontacted participant...
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Open AccessImpact of socioeconomic and cardiovascular risk factors on the effect of genetic variants associated with NT-proBNP
N-terminal prohormone of brain natriuretic peptide (NT-proBNP) is an established biomarker for diagnosis of heart failure. The study aims to explore whether known cardiovascular risk factors, including educati...
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Open AccessExternal validation of six clinical models for prediction of chronic kidney disease in a German population
Chronic kidney disease (CKD) is responsible for large personal health and societal burdens. Screening populations at higher risk for CKD is effective to initiate earlier treatment and decelerate disease progre...
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Neuer Standard: Kombinationstherapie zur Behandlung von Fettstoffwechselstörungen
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Open AccessA genetic risk score of alleles related to MGUS interacts with socioeconomic position in a population-based cohort
Environmental, genetic, and social factors are suggested to jointly influence monoclonal gammopathy of undetermined significance (MGUS), a precursor of multiple myeloma. Aim of this study was to investigate in...
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Open AccessMonoclonal gammopathy of undetermined significance is associated with prostate cancer in a population-based cohort study
Register-based studies indicate a possible association of monoclonal gammopathy of undetermined significance (MGUS) and prostate cancer (PCa). Aim of the present study was to investigate the relationship betwe...
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Open AccessAssociation between socioeconomic position and cystatin C in the Heinz Nixdorf Recall Study
Social inequalities in health and disease are well studied. Less information is available on inequalities in biomarker levels indicating subclinical stages of disease such as cystatin C, an early diagnostic ma...
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Open AccessA genetic sum score of effect alleles associated with serum lipid concentrations interacts with educational attainment
High-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and total cholesterol (TC) levels are influenced by both genes and the environment. The aim was to investigate whether...
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Open AccessPharmacogenetic association of diabetes-associated genetic risk score with rapid progression of coronary artery calcification following treatment with HMG-CoA-reductase inhibitors —results of the Heinz Nixdorf Recall Study
HMG-CoA-Reductase inhibitors (HMGRIs) are currently the most widely used group of drugs in patients with coronary artery disease (CAD) and are given preemptively to patients with high levels of cholesterol, in...
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Open AccessRisk prediction for coronary heart disease by a genetic risk score - results from the Heinz Nixdorf Recall study
A Genetic risk score for coronary artery disease (CAD) improves the ability of predicting coronary heart disease (CHD). It is unclear whether i) the use of a CAD genetic risk score is superior to the measureme...
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Erratum zu: Tako-Tsubo-Syndrom
Im Textabschnitt „Dynamische Obstruktion des linksventrikulären Ausflusstraktes“ des Beitrags wurden die Wörter „Hyperkontraktilität“ und „Hypokontraktilität“ vertauscht. Bitte beachten Sie den folgenden korri...
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Open AccessAssociations between self-reported sleep characteristics and incident mild cognitive impairment: The Heinz Nixdorf Recall Cohort Study
Associations of sleep characteristics with mild cognitive impairment (MCI) have been examined in cross-sectional, but rarely in longitudinal studies. Incident MCI and sleep characteristics were assessed in 1,8...
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Open AccessAssociation between lipoprotein(a) (Lp(a)) levels and Lp(a) genetic variants with coronary artery calcification
To examine the association between lipoprotein(a) (Lp(a)) levels, LPA (rs10455872 and rs3798220) and IL1F9 (rs13415097) single nucleotide polymorphisms (SNPs) with coronary artery calcification (CAC), an importan...
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Evidenzbasierte Primärprävention
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Erratum zu: Bildung, ausgewählte Ernährungseinstellungen und Ernährungsverhalten. Ergebnisse der Heinz Nixdorf Recall-Studie
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Open AccessErratum to: Long-term exposure to fine particulate matter and incidence of type 2 diabetes mellitus in a cohort study: effects of total and traffic-specific air pollution
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Open AccessLong working hours and cancer risk: a multi-cohort study
Working longer than the maximum recommended hours is associated with an increased risk of cardiovascular disease, but the relationship of excess working hours with incident cancer is unclear.
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Open AccessNormal liver enzymes are correlated with severity of metabolic syndrome in a large population based cohort
Key features of the metabolic syndrome are insulin resistance and diabetes. The liver as central metabolic organ is not only affected by the metabolic syndrome as non-alcoholic fatty liver disease (NAFLD), but...
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Open AccessLong-term exposure to fine particulate matter and incidence of type 2 diabetes mellitus in a cohort study: effects of total and traffic-specific air pollution
Studies investigating the link between long-term exposure to air pollution and incidence of diabetes are still scarce and results are inconsistent, possibly due to different compositions of the particle mixtur...