-
Chapter
Pathophysiologie: Lipidstoffwechsel
Die Leber gilt als das zentrale Stoffwechselorgan des menschlichen Körpers. Neben Proteinbiosynthese, Wärmeregulierung, Glukoseverwertung und Biotransformation sind die Hepatozyten vor allem der Hauptumschlagp...
-
Article
Open AccessKrüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury
Krüppel-like factor 6 (KLF6) is a transcription factor and tumor suppressor. We previously identified KLF6 as mediator of hepatocyte glucose and lipid homeostasis. The loss or reduction of KLF6 is linked to th...
-
Article
Open AccessNormal liver enzymes are correlated with severity of metabolic syndrome in a large population based cohort
Key features of the metabolic syndrome are insulin resistance and diabetes. The liver as central metabolic organ is not only affected by the metabolic syndrome as non-alcoholic fatty liver disease (NAFLD), but...
-
Article
Open AccessSerum sodium based modification of the MELD does not improve prediction of outcome in acute liver failure
Acute liver failure (ALF) is a devastating clinical syndrome with a high mortality rate. The MELD score has been implied as a prognostic tool in ALF. Hyponatremia is associated with lethal outcome in ALF. Incl...
-
Chapter
Fibrosis as a Major Mechanism of Chronic Liver Disease
Hepatic fibrosis and even cirrhosis have emerged as treatable and reversible consequences of chronic liver disease. With dramatic advances in understanding the cellular and molecular basis of fibrosis, there i...
