257 Result(s)

Article

Aggregation of type-2 diabetes, prediabetes, and metabolic syndrome in German couples

We aimed to examine the concordance of type-2 diabetes, prediabetes and the metabolic syndrome in couples. In cross-sectional analyses, we used data from 1173 couples with index persons from the Heinz Nixdorf ...

Lara Brieger, Sara Schramm, Börge Schmidt, Ulla Roggenbuck… in Scientific Reports (2024)

Article

Synergism between coexisting eye diseases and sex in increasing the prevalence of the dry eye syndrome

The aim was to investigate prevalence of dry eye syndrome (DES) in a population-based sample in Germany. The association between coexisting eye diseases and DES was also of interest. We recontacted participant...

Andreas Stang, Börge Schmidt, Sara Schramm, Bernd Kowall… in Scientific Reports (2024)

Article

Impact of socioeconomic and cardiovascular risk factors on the effect of genetic variants associated with NT-proBNP

N-terminal prohormone of brain natriuretic peptide (NT-proBNP) is an established biomarker for diagnosis of heart failure. The study aims to explore whether known cardiovascular risk factors, including educati...

Emanuel Matusch, Mirjam Frank, Kaffer Kara, Amir A. Mahabadi… in Scientific Reports (2022)

Article

External validation of six clinical models for prediction of chronic kidney disease in a German population

Chronic kidney disease (CKD) is responsible for large personal health and societal burdens. Screening populations at higher risk for CKD is effective to initiate earlier treatment and decelerate disease progre...

Susanne Stolpe, Bernd Kowall, Denise Zwanziger, Mirjam Frank… in BMC Nephrology (2022)

Article

Neuer Standard: Kombinationstherapie zur Behandlung von Fettstoffwechselstörungen

Prof. Dr. med. Ulrich Laufs, Raimund Erbel in Herz (2022)

Article

A genetic risk score of alleles related to MGUS interacts with socioeconomic position in a population-based cohort

Environmental, genetic, and social factors are suggested to jointly influence monoclonal gammopathy of undetermined significance (MGUS), a precursor of multiple myeloma. Aim of this study was to investigate in...

Lisa Baak, Mirjam Frank, Jan Dürig, Ulrich Dührsen, Per Hoffmann… in Scientific Reports (2022)

Article

Monoclonal gammopathy of undetermined significance is associated with prostate cancer in a population-based cohort study

Register-based studies indicate a possible association of monoclonal gammopathy of undetermined significance (MGUS) and prostate cancer (PCa). Aim of the present study was to investigate the relationship betwe...

Nicola Hornung, Mirjam Frank, Nico Dragano, Jan Dürig, Ulrich Dührsen… in Scientific Reports (2021)

Article

Association between socioeconomic position and cystatin C in the Heinz Nixdorf Recall Study

Social inequalities in health and disease are well studied. Less information is available on inequalities in biomarker levels indicating subclinical stages of disease such as cystatin C, an early diagnostic ma...

Tanja Zamrik, Mirjam Frank, Carina Emmel, Lars Christian Rump… in Scientific Reports (2021)

Article

A genetic sum score of effect alleles associated with serum lipid concentrations interacts with educational attainment

High-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and total cholesterol (TC) levels are influenced by both genes and the environment. The aim was to investigate whether...

Carina Emmel, Mirjam Frank, Nico Dragano, Markus M. Nöthen… in Scientific Reports (2021)

Article

Pharmacogenetic association of diabetes-associated genetic risk score with rapid progression of coronary artery calcification following treatment with HMG-CoA-reductase inhibitors —results of the Heinz Nixdorf Recall Study

HMG-CoA-Reductase inhibitors (HMGRIs) are currently the most widely used group of drugs in patients with coronary artery disease (CAD) and are given preemptively to patients with high levels of cholesterol, in...

Sonali Pechlivanis, Dominik Jung… in Naunyn-Schmiedeberg's Archives of Pharmaco… (2021)

Article

Risk prediction for coronary heart disease by a genetic risk score - results from the Heinz Nixdorf Recall study

A Genetic risk score for coronary artery disease (CAD) improves the ability of predicting coronary heart disease (CHD). It is unclear whether i) the use of a CAD genetic risk score is superior to the measureme...

Sonali Pechlivanis, Nils Lehmann, Per Hoffmann, Markus M. Nöthen… in BMC Medical Genetics (2020)

Article

Erratum zu: Tako-Tsubo-Syndrom

Im Textabschnitt „Dynamische Obstruktion des linksventrikulären Ausflusstraktes“ des Beitrags wurden die Wörter „Hyperkontraktilität“ und „Hypokontraktilität“ vertauscht. Bitte beachten Sie den folgenden korri...

Prof. Dr. med. Stefan Möhlenkamp, Petra Kleinbongard, Raimund Erbel in Der Kardiologe (2020)

Article

Associations between self-reported sleep characteristics and incident mild cognitive impairment: The Heinz Nixdorf Recall Cohort Study

Associations of sleep characteristics with mild cognitive impairment (MCI) have been examined in cross-sectional, but rarely in longitudinal studies. Incident MCI and sleep characteristics were assessed in 1,8...

Christian Brachem, Angela Winkler, Sarah Tebrügge, Christian Weimar… in Scientific Reports (2020)

Article

Association between lipoprotein(a) (Lp(a)) levels and Lp(a) genetic variants with coronary artery calcification

To examine the association between lipoprotein(a) (Lp(a)) levels, LPA (rs10455872 and rs3798220) and IL1F9 (rs13415097) single nucleotide polymorphisms (SNPs) with coronary artery calcification (CAC), an importan...

Sonali Pechlivanis, Amir A. Mahabadi, Per Hoffmann… in BMC Medical Genetics (2020)

Article

Evidenzbasierte Primärprävention

Prof. Dr. med. Heribert Schunkert, Raimund Erbel in Herz (2020)