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Article
Open AccessSingle-cell analyses reveal transient retinal progenitor cells in the ciliary margin of develo** human retina
The emergence of retinal progenitor cells and differentiation to various retinal cell types represent fundamental processes during retinal development. Herein, we provide a comprehensive single cell characteri...
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Article
Open AccessSingle-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission
Immune-mediated inflammatory diseases (IMIDs) are typically characterised by relapsing and remitting flares of inflammation. However, the unpredictability of disease flares impedes their study. Addressing this...
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Article
Open AccessSingle-cell DNA sequencing identifies risk-associated clonal complexity and evolutionary trajectories in childhood medulloblastoma development
We reconstructed the natural history and temporal evolution of the most common childhood brain malignancy, medulloblastoma, by single-cell whole-genome sequencing (sc-WGS) of tumours representing its major mol...
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Article
Open AccessDelayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2
The nasal epithelium is a plausible entry point for SARS-CoV-2, a site of pathogenesis and transmission, and may initiate the host response to SARS-CoV-2. Antiviral interferon (IFN) responses are critical to o...
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Article
Open AccessMsx1 haploinsufficiency modifies the Pax9-deficient cardiovascular phenotype
Successful embryogenesis relies on the coordinated interaction between genes and tissues. The transcription factors Pax9 and Msx1 genetically interact during mouse craniofacial morphogenesis, and mice deficient f...
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Article
Blood and immune development in human fetal bone marrow and Down syndrome
Haematopoiesis in the bone marrow (BM) maintains blood and immune cell production throughout postnatal life. Haematopoiesis first emerges in human BM at 11–12 weeks after conception1,2, yet almost nothing is know...
