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  1. Article

    Open Access

    Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia

    KMT2A-rearranged infant ALL is an aggressive childhood leukemia with poor prognosis. Here, we investigated the developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia (B-ALL) using bulk...

    Eleonora Khabirova, Laura Jardine, Tim H. H. Coorens, Simone Webb… in Nature Medicine (2022)

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  2. No Access

    Article

    Blood and immune development in human fetal bone marrow and Down syndrome

    Haematopoiesis in the bone marrow (BM) maintains blood and immune cell production throughout postnatal life. Haematopoiesis first emerges in human BM at 11–12 weeks after conception1,2, yet almost nothing is know...

    Laura Jardine, Simone Webb, Issac Goh, Mariana Quiroga Londoño, Gary Reynolds… in Nature (2021)

  3. Article

    A roadmap for the Human Developmental Cell Atlas

    The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human Cell Atlas, aims to create a comprehensive reference map of cells during development. This will be critical to understanding nor...

    Muzlifah Haniffa, Deanne Taylor, Sten Linnarsson, Bruce J. Aronow, Gary D. Bader… in Nature (2021)

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  4. Article

    Open Access

    Single-cell multi-omics analysis of the immune response in COVID-19

    Analysis of human blood immune cells provides insights into the coordinated response to viral infections such as severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19...

    Emily Stephenson, Gary Reynolds, Rachel A. Botting… in Nature Medicine (2021)

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  5. No Access

    Article

    Decoding human fetal liver haematopoiesis

    Definitive haematopoiesis in the fetal liver supports self-renewal and differentiation of haematopoietic stem cells and multipotent progenitors (HSC/MPPs) but remains poorly defined in humans. Here, using sing...

    Dorin-Mirel Popescu, Rachel A. Botting, Emily Stephenson, Kile Green, Simone Webb… in Nature (2019)