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Article
Open AccessSingle-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission
Immune-mediated inflammatory diseases (IMIDs) are typically characterised by relapsing and remitting flares of inflammation. However, the unpredictability of disease flares impedes their study. Addressing this...
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Article
Open AccessNumber of days required to measure sedentary time and physical activity using accelerometery in rheumatoid arthritis: a reliability study
This study aimed to determine the minimum number of days required to reliably estimate free-living sedentary time, light-intensity physical activity (LPA) and moderate-intensity physical activity (MPA) using a...
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Article
Open AccessEstimated pulse wave velocity improves risk stratification for all-cause mortality in patients with COVID-19
Accurate risk stratification in COVID-19 patients consists a major clinical need to guide therapeutic strategies. We sought to evaluate the prognostic role of estimated pulse wave velocity (ePWV), a marker of ...
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Article
Open AccessBIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (the BIO-FLARE study): protocol for a non-randomised longitudinal cohort study
Our knowledge of immune-mediated inflammatory disease (IMID) aetiology and pathogenesis has improved greatly over recent years, however, very little is known of the factors that trigger disease relapses (flare...
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Article
Open AccessSingle-cell multi-omics analysis of the immune response in COVID-19
Analysis of human blood immune cells provides insights into the coordinated response to viral infections such as severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19...
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Article
Open Access“Living a normal life”: a qualitative study of patients’ views of medication withdrawal in rheumatoid arthritis
Withdrawal of disease-modifying anti-rheumatic drugs (DMARDs) once disease remission is achieved is endorsed by current international rheumatoid arthritis (RA) management guidelines. However, very little data ...
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Article
Open AccessUse of structured musculoskeletal examination routines in undergraduate medical education and postgraduate clinical practice – a UK survey
Structured examination routines have been developed as educational resources for musculoskeletal clinical skills teaching, including Gait-Arms-Legs-Spine (GALS), Regional Examination of the Musculoskeletal Sys...
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Article
Possible gene centers for resistance in the genusBrassica toPlasmodiophora Brassicae
There is urgent need for surveying wild populations ofBrassica spp. for additional genes for resistance to Plasmodiophora brassicae. The gene centers of the genusBrassica and of cultivatedB. oleracea are in the w...
