22 Result(s)

Article

VAV1 regulates experimental autoimmune arthritis and is associated with anti-CCP negative rheumatoid arthritis

Rheumatoid arthritis (RA) patients can be stratified into two subgroups defined by the presence or absence of antibodies against citrullinated circular peptides (anti-CCP) with most of the genetic association ...

A O Guerreiro-Cacais, U Norin, A Gyllenberg, R Berglund, A D Beyeen… in Genes & Immunity (2017)

Article

Finemap** of the arthritis QTL Pia7 reveals co-localization with Oia2 and the APLEC locus

In this study, we sought to determine the effect of the quantitative trait locus Pia7 on arthritis severity. The regulatory locus derived from the arthritis-resistant E3 rat strain was introgressed into the arthr...

C Rintisch, T Kelkka, U Norin, J C Lorentzen, P Olofsson, R Holmdahl in Genes & Immunity (2010)

Article

Cell-specific and efficient expression in mouse and human B cells by a novel hybrid immunoglobulin promoter in a lentiviral vector

The expression of genes specifically in B cells is of great interest in both experimental immunology as well as in future clinical gene therapy. We have constructed a novel enhanced B cell-specific promoter (I...

K L Laurie, M P Blundell, H E Baxendale, S J Howe, J Sinclair, W Qasim… in Gene Therapy (2007)

Chapter and Conference Paper

Nature's Choice of Genes Controlling Chronic Inflammation

Inflammation is a physiological response that may go uncontrolled and thereby develop in a chronic way. This seems to happen in many common diseases of autoimmune, degenerative, or allergic char...

R. Holmdahl in Immunotherapy in 2020 (2007)

Chapter

Genetics of Autoimmune Diseases: A Multistep Process

It has so far been difficult to identify genes behind polygenic autoimmune diseases such as rheumatoid arthritis (RA), multiple sclerosis (MS), and type I diabetes (T1D). With proper animal models, some of the...

M. Johannesson, M. Hultqvist, R. Holmdahl in Current Concepts in Autoimmunity and Chron… (2006)

Article

Gene expression profiling of arthritis using a QTL chip reveals a complex gene regulation of the Cia5 region in mice

One of the major quantitative trait loci (QTLs) associated with arthritis in crosses between B10.RIII and RIIIS/J mice is the Cia5 on chromosome 3. Early in the congenic map** process it was clear that the locu...

M Johannesson, L M Olsson, A-K B Lindqvist, S Möller, D Koczan… in Genes & Immunity (2005)

Article

Identification of epistasis through a partial advanced intercross reveals three arthritis loci within the Cia5 QTL in mice

Identification of genes controlling complex diseases has proven to be difficult; however, animal models may pave the way to determine how low penetrant genes interact to promote disease development. We have di...

M Johannesson, J Karlsson, P Wernhoff, K S Nandakumar, A-K Lindqvist… in Genes & Immunity (2005)

Chapter and Conference Paper

Antileukoproteinase reduziert die zelluläre Entzündungsreaktion nach anti-Kollagen II Antikörper induzierter rheumatoider Arthritis in einem Tiermodell der Maus

Using high resolution multi-fluorescence microscopy, we herein report on the efficiency of recombinant human antileukoproteinase (ALP) to reduce inflammatory sequelae in the mouse synovial tissue after anti-co...

Dr. med. Philip Gierer, A. Kühl, S. Ibrahim, H. Burkhardt… in Chirurgisches Forum 2005 (2005)

Article

Genistein as an anti-inflammatory agent

Objective and design: The aim of this study was to investigate the impact of the isoflavone genistein on in vivo cell-mediated responses. In addition, we wanted to study the influence of genistein on collagen in...

M. Verdrengh, I. M. Jonsson, R. Holmdahl, A. Tarkowski in Inflammation Research (2003)

Article

Estrogen-mediated immunosuppression in autoimmune diseases

Gender affects the susceptibility to many autoimmune diseases. Women have an increased risk of develo** diseases such as rheumatoid arthritis and multiple sclerosis compared with men. The female preponderan...

L. Jansson, R. Holmdahl in Inflammation Research (1998)

Article

Letters to the editor

M. Andersson, L. Jansson, R. Holmdahl in Immunogenetics (1992)

Chapter and Conference Paper

Type-II Collagen in the Pathogenesis of Rheumatoid Arthritis

Rheumatoid arthritis (RA) is now generally regarded as an autoimmune disease with relapsing or progressive occurrence of arthritis affecting preferentially peripheral joints. In spite of the fact that it is a ...

R. Holmdahl in Rheumatoid Arthritis (1992)