SpringerLink
Log in

Type-II Collagen in the Pathogenesis of Rheumatoid Arthritis

  • Conference paper
Rheumatoid Arthritis

  • 189 Accesses

Abstract

Rheumatoid arthritis (RA) is now generally regarded as an autoimmune disease with relapsing or progressive occurrence of arthritis affecting preferentially peripheral joints. In spite of the fact that it is a severe and crippling disease affecting a large population, very little is known of its etiology and pathogenesis, although many of its seconday manifestations have been well described. Fortunately, basic research has made considerable progress which now make it possible (a) to evolve the structural requirements for one critical event of importance in RA, the trimolecular interaction between an autoantigenic peptide on major histocompatibility complex (MHC) class-II molecule and the T-cell receptor, and (b) to rapidly increase our knowledge of the basic rules for self- and non-self-discrimination by the immune system. Analysis of the MHC class-II genes which confer a high risk of develo** RA suggests that many, perhaps a majority of patients suffering from the syndrome classified as RA according to the criteria of the Arthritis Rheumatism Association actually suffer from a single disease entity with a pathologic response to a particular autoantigen. Considering the preferential involvement of peripheral joints in RA, it is likely that this particular antigen is a molecule specifically located in joint tissues. In this chapter the descriptive findings of autoimmune reactions to cartilage-specific type-II collagen (CII) in RA are reviewed and the general requirements for recognition of these molecules by the immune system are discussed.

This work was supported by the Swedish Medical Research Council, the Craaford Foundation, the King Gustav V 80-years Foundation, the Nanna Swartz Foundation, and National League against Rheumatism.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
EUR 29.95
Price includes VAT (France)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
EUR 117.69
Price includes VAT (France)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
EUR 158.24
Price includes VAT (France)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Von Der Mark H, Von Der Mark K, Gay S (1976) Study of differential collagen synthesis during development of the chick embryo by immunofluorescence. I. Preparation of collagen type I and type II specific antibodies and their application to early stages of the chick embryo. Dev Biol 48:237–249

    PubMed  Google Scholar 

  2. Thorogood P, Bee J, Von Der Mark K (1986) Transient expression of collagen type II at epitheliomesenchymal interfaces during morphogenesis of cartilaginous neurocranium. Dev Biol 116:497–509

    CAS  PubMed  Google Scholar 

  3. Denecke R, Trautwein G, Kaup FJ (1986) The role of cartilage canals in the pathogenesis of experimentally induced polyarthritis. Rheumatol Int 6:239–243

    CAS  PubMed  Google Scholar 

  4. Klareskog L, Forsum U, Wigzell H (1982) Murine synovial intima contains I-A-, i-E/C-positive bone marrow-derived cells. Scand J Immunol 15:509–514

    Google Scholar 

  5. Inaba K, Steinman R (1983) Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and in man. Proc Natl Acad Sci USA 80:6041–6045

    CAS  PubMed  Google Scholar 

  6. Metlay JP, Puré E, Steinman RM (1989) Control of the immune response at the level of antigen-presenting cells: a comparison of the function of dendritic cells and B lymphocytes. Adv Immunol 47:45–116

    CAS  PubMed  Google Scholar 

  7. Stuart JM, Cremer MA, Townes AS, Kang AH (1982) Type-II-collagen-induced arthritis in rats. Passive transfer with serum and evidence that IgG anti-collagen antibodies can cause arthritis. J Exp Med 155:1–16

    CAS  PubMed  Google Scholar 

  8. Stuart JM, Dixon FJ (1983) Serum transfer of collagen-induced arthritis in mice. J Exp Med 158:378–392

    CAS  PubMed  Google Scholar 

  9. Stuart JM, Tomoda K, Yoo TJ, Townes AS, Kang AH (1983) Serum transfer of collagen-induced arthritis. II. Identification and localization of autoantibody to type II collagen in donor and recipient rats. Arthritis Rheum 26:1237–1244

    CAS  PubMed  Google Scholar 

  10. Jonsson R, Karlsson AL, Holmdahl R (1989) Demonstration of immune-reactive sites on cartilage after in vivo administration of biotinylated anti-type II collagen antibodies. J Histochem Cytochem 37:265–268

    CAS  PubMed  Google Scholar 

  11. Holmdahl R, Mo J, Jonsson R, Karlström K, Scheynius A (1991) Multiple epitopes on cartilage type II collagen are accesible for antibody binding in vivo. Autoimmunity (in press)

    Google Scholar 

  12. Stastny P (1978) Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N Engl J Med (1978) 298:869–871

    CAS  PubMed  Google Scholar 

  13. Gregersen PK, Shen M, Song Q, Merryman P, Dagar S, Seki T, Maccari J, Goldberg D, Murphy H, Schwenzer J, Wang CY, Winchester RJ, Nepom GT, Silver J (1986) Molecular diversity of HLA-DR4 haplotypes. Proc Natil Acad Sci USA 83:2642–2646

    CAS  Google Scholar 

  14. Gregersen PK, Silver J, Wincester RJ (1987) The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 30:1205–1213

    CAS  PubMed  Google Scholar 

  15. Nepom GT, Byers P, Seyfried C, Healey LA, Wilske KR, Stage D, Nepom BS (1989) HLA genes associated with rheumatoid arthritis. Identification of susceptibility alleles using specific oligonucleotide probes. Arthritis Rheum 32:15–21

    CAS  PubMed  Google Scholar 

  16. Brown JH, Jardetzky T, Saper MA, Samraoui B, Bjorkman PJ, Wiley DC (1988) A hypothetical model of the foreign antigen-binding site of class-II histocompatibility molecules. Nature 332:845–850

    CAS  PubMed  Google Scholar 

  17. Howell WM, Evans PR, Wilson PJ, Cawley MID, Smith JL (1989) HLA class-II DR, DQ, and DP restriction fragment length polymorphisms in rheumatoid arthritis. Ann Rheum Dis 48:295–301

    CAS  PubMed  Google Scholar 

  18. Burmester GR, Yu DTY, Irani AM, Kunkel HG, Winchester RJ (1981) Ia+ T cells in synovial fluid and tissue of patients with rheumatoid arthritis. Arthritis Rheum 24:1370–1376

    CAS  PubMed  Google Scholar 

  19. Burmester GR, Jahn B, Gramatzki M, Zacher J, Kalden JR (1984) Activated T cells in vitro and in vivo: divergence in expression of Tac and Ia antigens in the nonblastoid small T cells of inflammation and normal T cells activated in vitro. J Immunol 133:1230–1234

    CAS  PubMed  Google Scholar 

  20. Janossy G, Panai G, Duke O, Bofill M, Poulter LW, Goldstein G (1981) Rheumatoid arthritis: a disease of T lymphocyte/macrophage immunoregulation. Lancet 2:839–843

    CAS  PubMed  Google Scholar 

  21. Klareskog L, Forsum U, Scheynius A, Kabelitz D, Wigzell H (1982) Evidence in support of a self-perpetuating HLA-DR dependent delayed-type hypersensitivity reaction in rheumatid arthritis. Proc Natl Acad Sci USA 79:3632–3636

    CAS  PubMed  Google Scholar 

  22. Scher MG, Beller DI, Unanue ER (1980) Demonstration of a soluble mediator that induces exudates rich in la-positive macrophages. J Exp Med 152:1684–1698

    CAS  PubMed  Google Scholar 

  23. Mosmann TR, Coffman RL (1989) TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7:145–173

    CAS  PubMed  Google Scholar 

  24. Husby G, Williams RC (1985) Immunohistochemical studies of interleukin-2 and gamma-interferon in rheumatoid arthritis. Arthritis Rheum 28:174–181

    CAS  PubMed  Google Scholar 

  25. Buchan G, Barrett K, Fujita T, Taniguchi T, Maini R, Feldmann M (1988) Detection of activated T cell products in the rheumatoid joint using cDNA probes to interleukin-2 (IL-2), IL-2 receptor and IFN-gamma. Clin Exp Immunol 71:295–301

    CAS  PubMed  Google Scholar 

  26. Zvaifler NJ (1973) The immunopathology of joint inflammation in rheumatoid arthritis. Adv Immunol 16:265–336

    CAS  PubMed  Google Scholar 

  27. Carson DA, Chen PP, Fox RI, Kipps TJ, Jirik F, Goldfien RD, Silverman G, Radoux V, Fong S (1987) Rheumatoid factor and immune networks. Annu Rev Immunol 5:109–126

    CAS  PubMed  Google Scholar 

  28. Nemazee DA (1985) Immune complexes can trigger specific T-cell-dependent, autoanti-IgG antibody production in mice. J Exp Med 161:242–256

    CAS  PubMed  Google Scholar 

  29. Stamenkovic I, Stegano M, Wright KA, Krane SM, Amento EP, Colvin RB, Duquesnoy RJ, Kurnick JT (1988) Clonal dominance among T-lymphocyte infiltrates in arthritis. Proc Natl Acad Sci USA 85:1179–1183

    CAS  PubMed  Google Scholar 

  30. Schluesener HJ, Wekerle H (1985) Autoaggressive T lymphocyte lines recognizing the encephalitogenic region of myelin basic protein: in vitro selection from unprimed T lymphocyte populations. J Immunol 135:3128–3133

    CAS  PubMed  Google Scholar 

  31. Trentham DE, Townes AS, Kang AH (1977) Autoimmunity to type II collagen: an experimental model of arthritis. J Exp Med 146:857–868

    CAS  PubMed  Google Scholar 

  32. Morgan K, Evans HB, Firth SA, Smith MN, Ayad S, Weiss JB, Holt PJL (1983) 1-alpha, 2-alpha, 3-alpha collagen is arthritogenic. Ann Rheum Dis 42:680–683

    CAS  PubMed  Google Scholar 

  33. Glant TT, Mikecz K, Arzoumanian A, Poole AR (1987) Proteoglycan-induced arthritis in Balb/c mice. Arthritis Rheum 30:201–212

    CAS  PubMed  Google Scholar 

  34. Courtenay JS, Dallman MJ, Dayan AD, Martin A, Mosedal B (1980) Immunization against heterologous type II collagen induces arthritis in mice. Nature 283:666–667

    CAS  PubMed  Google Scholar 

  35. Yoo TJ, Kim SY, Stuart JM, Floyd RA, Olson GA, Cremer MA, Kang AH (1988) Induction of arthritis in monkeys by immunization with type II collagen. J Exp Med 168:777–782

    CAS  PubMed  Google Scholar 

  36. Wooley PH, Luthra HS, Stuart JM, David CS (1981) Type II collagen induced arthritis in mice. I. Major histocompatibility complex (I-region) linkage and antibody correlates. J Exp Med 154:688–700

    CAS  PubMed  Google Scholar 

  37. Wooley PH, Luthra HS, Griffiths MM, Stuart JM, Huse A, David CS (1985) Type II collagen induced arthritis in mice. IV. Variations in immunogenetic regulation provide evidence for multiple arthritogenic epitopes on the collagen molecule. J Immunol 135:2443–2451

    CAS  PubMed  Google Scholar 

  38. Holmdahl R, Klareskog L, Andersson M, Hansen C (1986) High antibody response to autologous type II collagen is restricted to H-2q. Immunogenetics 24:84–89

    CAS  PubMed  Google Scholar 

  39. Holmdahl R, Jansson L, Andersson M, Larsson E (1988) Immunogenetics of type II collagen autoimmunity and susceptibility to collagen arthritis. Immunology 65:305–310

    CAS  PubMed  Google Scholar 

  40. Holmdahl R, Karlsson M, Andersson ME, Rask L, Andersson L (1989) Localization of a critical restriction site on the I-A-beta chain which determines susceptibility to collagen-induced arthritis. Proc Natl Acad Sci USA 86:9475–9479

    CAS  PubMed  Google Scholar 

  41. Gustafsson K, KarlssonM, Andersson L, Holmdahl R (1990) Structures on the I-A molecule which predisposes for susceptibiity to collagen-induced arthritis and for type II collagen autoimmune response. Eur J Immunol 20:2127–2131

    CAS  PubMed  Google Scholar 

  42. Holmdahl R, Jansson L, Larsson E, Rubin K, Klareskog L (1986) Homologous type II collagen induces chronic and progressive arthritis in mice. Arthritis Rheum 29:106–113

    CAS  PubMed  Google Scholar 

  43. Trentham DE (1982) Collagen arthritis as a relevant model for rheumatoid arthritis. Evidence pro and con. Arthritis Rheum 25:911–916

    CAS  PubMed  Google Scholar 

  44. 44. Holmdahl R (1988) Collagen-induced arthritis, Int Rev Immunol Vol 4 Harwood, New York

    Google Scholar 

  45. Holmdahl R, Andersson ME, Goldschmidt TJ, Gustafsson K, Jansson L, Mo J (1990) Type II collagen autoimmunity in animals and provocations leading to arthritis. Immunol Rev 118:193–232

    CAS  PubMed  Google Scholar 

  46. Kresina TF, Moskowitz RW (1985) Adoptive transfer of suppression of arthritis in the mouse model of collagen-induced arthritis. J Clin Invest 75:1990–1998

    CAS  PubMed  Google Scholar 

  47. Englert M, McReynolds RA, Landes MJ, Oronsky AL, Kerwar SS (1985) Pretreatment of rats with anticollagen IgG renders them resistant to active type II collagen arthritis. Cell Immunol 90:258–266

    CAS  PubMed  Google Scholar 

  48. Larsson P, Kleinau S, Holmdahl R, Klareskog L (1990) Autologous collagen-II-inducd arthritis in rats. Demonstration of clinically distinct forms of arthritis in two strains of rats. Arthritis Rheum (in press)

    Google Scholar 

  49. Andersson M, Holmdahl R (1990) Analysis of type II collagen-reactive T cells in the mouse. I. Different regulation of autoreactie versus non-autoreactive anti-CII T cells in the DBA/1 mouse. Eur J Immunol 20:1061–1066

    CAS  PubMed  Google Scholar 

  50. Holmdahl R, Andersson M, Tarkowski A (1987) Origin of the autoreactive anti-type II collagen response. I. Frequency of specific and multispecific B cells in primed murine lymph nodes. Immunology 61:369–374

    CAS  PubMed  Google Scholar 

  51. Holmdahl R, Bailey C, Enander I, Mayer R, Klareskog L, Moran T, Bona C (1989) Origin of the autoreactive anti-type II collagen response. II. Specificities, isotypes and usage of V gene families of anti-type II collagen autoantibodies. J Immunol 142:1881–1886

    CAS  PubMed  Google Scholar 

  52. Klareskog L, Holmdahl R, Larsson E, Wigzell H (1983) Role of lymphocytes in collagen-II-induced arthritis in rats. Clin Exp Immunol 51:117–125

    CAS  PubMed  Google Scholar 

  53. Brahn E, Trentham DE (1984) Effect of antithymocyte serum on collagen arthritis in rats: evidence that T cells are involved in its pathogenesis. Cell Immunol 86:421–428

    CAS  PubMed  Google Scholar 

  54. Ranges GE, Sriram S, Cooper SM (1985) Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4. J Exp Med 162:1105–1110

    CAS  PubMed  Google Scholar 

  55. Holmdahl R, Jonsson R, Larsson P, Klareskog L (1988) Early appearance of activated CD 4 positive T lymphocytes and la-expressing cells in joints of DBA/1 mice immunized with type II collagen. Lab Invest 58:53–60

    CAS  PubMed  Google Scholar 

  56. Holmdahl R, Tarkowski A, Jonsson R (1991) Involvement of macrophages and dendritic cells in synovial inflammation of collagen-induced arthritis in DBA/1 mice and spontaneous arthritis in MRL/lpr mice. Autoimmunity (in press)

    Google Scholar 

  57. Mauritz NJ, Holmdahl R, Jonsson R, Van Der Meide P, Scheynius A, Klareskog L (1988) Treatment with interferon-gamma triggers onset of collagen arthritis in mice. Arthritis Rheum 31:1297–1304

    CAS  PubMed  Google Scholar 

  58. Caulfield JP, Hein A, Dynesius-Trentham R, Trentham DE (1982) Morphological demonstration of two stages in the development of type II collagen-induced arthritis. Lab Invest 46:321–343

    CAS  PubMed  Google Scholar 

  59. Kerwar SS, Englert ME, McReynolds RA, Landes MJ, Lloyd JM, Oronsky AL, Wilson FJ (1983) Type II collagen-induced arthritis. Studies with purified anticollagen immunoglobulin. Arthritis Rheum 26:1120–1131

    CAS  PubMed  Google Scholar 

  60. Holmdahl R, Jansson L, Larsson A, Jonsson R (1990) Arthritis in DBA/1 mice induced with passively transferred type II collagen immune serum. Immunohistopathology and serum levels of anti-type II collagen autoantibodies. Scand J Immunol 31:147–157

    CAS  PubMed  Google Scholar 

  61. Steffen C, Ludwig H, Knapp W (1974) Collagen-anticollagen immune complexes in rheumatoid arthritis synovial fluid cells. Z Immuni Aaetsforsch 147:229–235

    CAS  Google Scholar 

  62. Menzel J, Steffen C (1982) Demonstration of C1q — binding to collagen-anticollagen immune complexes in synovial fluids of RA patients. Z Rheumatol 41:47–49

    CAS  PubMed  Google Scholar 

  63. Michaeli D, Fudenberg HH (1974) The incidence and antigenic specificity of antibodies against denatured human collagen in rheumatoid arthritis. Clin Immunol Immunopathol 2:153–159

    CAS  PubMed  Google Scholar 

  64. Andriopoulos NA, Mestecky J, Miller EJ, Bradley EL (1976) Antibodies to native and denatured collagens in sera of patients with rheumatoid arthritis. Arthritis Rheum 19:613–617

    CAS  PubMed  Google Scholar 

  65. Stuart JM, Huffstutter EH, Townes AS, Kang AH (1983) Incidence and specificity of antibodies to types I, II, III, IV, and V collagen in rheumatoid arthritis and other rheumatoid diseases as measured by 125I-radioimmunoassay. Arthritis Rheum 26:832–840

    CAS  PubMed  Google Scholar 

  66. Morgan K, Clague RB, Collins I, Ayad S, Phinn SD, Holt PJL (1987) Incidence of antibodies to native and denatured cartilage collagens (type II, IX, and XI) and to type I collagen in rheumatoid arthritis. Ann Rheum Dis 46:902–907

    CAS  PubMed  Google Scholar 

  67. Fuchs S, Mozes E, Maoz A, Sela M (1974) Thymus independence of a collagen-like synthetic polypeptide and of collagen, and the need for thymus and bone marrow-cell cooperation in the immune response to gelatin. J Exp Med 139:148–158

    CAS  PubMed  Google Scholar 

  68. Nowack H, Hahn E, Timpl R (1975) Specificity of the antibody response in inbred mice to bovine type I and type II collagen. Immunol 29:621–628

    CAS  Google Scholar 

  69. Hahn E, Nowack H, Götze D, Timpl R (1975) H-2 linked genetic control of antibody response to soluble calfskin collagen in mice. Eur J Immunol 5:288–291

    CAS  PubMed  Google Scholar 

  70. Hahn E, Timpl R, Miller EJ (1974) The production of specific antibodies to native collagens with the chain compositions, [alpha 1(I))] 3, [alpha 1(II)3], and [alpha 1(I)-2alpha2. J Immunol 113:421–423

    CAS  PubMed  Google Scholar 

  71. Kemp JD, Madri JA (1981) The immune response to human type II and type V (AB2) collagen: antigenic determinants and genetic control in mice. Eur J Immunol 11:90–94

    CAS  PubMed  Google Scholar 

  72. Beard HK, Ueda M, Faulk WP, Glynn LE (1978) Cell-mediated and humoral immunity to chick type II collagen and its cyanogen bromide peptides in guinea pigs. Immunology 34:323–334

    CAS  PubMed  Google Scholar 

  73. Ellingsworth LR, De Lustro F, Brennan JE, Sawamura S, McPherson J (1986) The human immune response to reconstituted bovine collagen. J Immmunol 136:877–882

    CAS  Google Scholar 

  74. Choi EKK, Gatenby PA, McGill NW, Bateman JF, Cole WG, York JR (1988) Autoantibodies to type II collagen: occurrence in rheumatoid arthritis, other arthritides, autoimmune connective tissue diseases, and chronic inflammatory syndromes. Ann Rheum Dis 47:313–322

    CAS  PubMed  Google Scholar 

  75. Cheung HS, Ryan LM, Kozin F, McCarty DJ (1980) Identification of collagen subtypes in synovial fluid sediments from arthritic patients. Am J Med 68:73–79

    CAS  PubMed  Google Scholar 

  76. Kitridou R, McCarty DJ, Prockop DJ, Hummeler K (1969) Identification of collagen in synovial fluid. Arthritis Rheum 12:580–588

    CAS  PubMed  Google Scholar 

  77. Wozniczko-Orlowska G, Milgrom F (1982) Collagen-anti-collagen complexes in rheumatoid arthritis sera. Int Arch Allergy Appl Immunol 68:28–34

    CAS  PubMed  Google Scholar 

  78. Rowley MJ, Williamson DJ, Mackay IR (1987) Evidence for local synthesis of antibodies to denatured collagen in the synovium in rheumatoid arthritis. Arthritis Rheum 30:1420–1425

    CAS  PubMed  Google Scholar 

  79. Stockman A, Rowley MJ, Emery P, Muirden KD (1989) Activity of rheumatoid arthritis and levels of collagen antibodies: a prospective study. Rheumatol Int 8:239–243

    CAS  PubMed  Google Scholar 

  80. Goodnow CC, Crosbie J, Jorgensen H, Brink RA, Basten A (1989) Induction of self-tolerance in mature peripheral B lymphocytes. Nature 342:385–391

    CAS  PubMed  Google Scholar 

  81. Nemazee D, Buerki K (1989) Clonal deletion of autoreactive B lymphocytes in bonemarrow chimeras. Proc Natl Acad Sci USA 86:8039–8043

    CAS  PubMed  Google Scholar 

  82. Clague RB, Firth SA, Holt PJL, Skingle J, Greenbury CL, Webley M (1983) Serum antibodies to type II collagen in rheumatoid arthritis: comparison of 6 immunological methods and clinical features. Ann Rheum Dis 42:537–544

    CAS  PubMed  Google Scholar 

  83. Alomari WRS, Archer JR, Brocklehurst R, Currey HLF (1983) Binding of immunoglobulins and immune complexes to cartilage-derived extracts. Clin Exp Immunol 54:716–722

    CAS  PubMed  Google Scholar 

  84. Rosenberg AM, Hunt WC, Petty RE (1984) Antibodies to native and denatured type II collagen in children with rheumatic diseases. J Rheumatol 11:425–431

    CAS  PubMed  Google Scholar 

  85. Kirk AP, O’Hara BP, Mageed RAK, McMahon MS, McCarthy D, Menashi S, Archer JR, Currey HLF. Pepsinogen — an immunoglobulin-binding artefact in collagen preparations. Clin Exp Immunol 65:671–678

    Google Scholar 

  86. Greenbury CL, Skingle J (1979) Anti-cartilage antibody. J Clin Pathol 32:826–831

    CAS  PubMed  Google Scholar 

  87. Beard HK, Ryvar R, Skingle J, Greenbury CL (1980) Anti-collagen antibodies in sera from rheumatoid arthritis patients. J Clin Pathol 33:1077–1081

    CAS  PubMed  Google Scholar 

  88. Dyer PA, Clague RB, Klouda PT, Firth S, Harris R, Holt PJL (1982) HLA antigens in patients with rheumatoid arthritis and antibodies to native type II collagen. Tissue Antigens 20:394–396

    CAS  PubMed  Google Scholar 

  89. Gioud M, Meghlaoui A, Costa O, Monier JC (1982) Antibodies to native type I and type II collagens detected by an enzyme-linked immunosorbent assay (ELISA) in rheumatoid arthritis and systemic lupus erythematosus. Coll Relat Res 2:557–564

    CAS  PubMed  Google Scholar 

  90. Pereira RS, Black CM, Duance VC, Jones VE, Jacoby RK, Welsh KI (1985) Disappearing collagen antibodies in rheumatoid arthritis. Lancet 2:501–502

    CAS  PubMed  Google Scholar 

  91. Watson WC, Cremer MA, Wooley PH, Townes AS (1986) Assessment of the potential pathogenicity of type II collagen autoantibodies in patients with rheumatoid arthritis. Evidence of restricted IgG3 subclass expression and activation of complement C5 to C5a. Arthritis Rheum 29:1316–1321

    CAS  PubMed  Google Scholar 

  92. Morgan K, Clague RB, Collins I, Ayad S, Phinn SD, Holt PJL (1989) A longitudinal study of anticollagen antibodies in patients with rheumatoid arthritis. Arthritis Rheum 32:139–145

    CAS  PubMed  Google Scholar 

  93. Foidart JM, ABe S, Martin GR, Zizic TM, Barnett EV, Lawley TJ, Katz SI (1978) Antibodies to type II collagen in relapsing polychondritis. N Engl J Med 299:1203–1207

    CAS  PubMed  Google Scholar 

  94. Clague RB, Shaw MJ, Holt PJL (1980) Incidence of serum antibodies to native type I and type II collagens in patients with inflammatory arthritis. Ann Rheum Dis 39:201–206

    CAS  PubMed  Google Scholar 

  95. Morgan K, Buckee C, Collins I, Ayad S, Clague RB, Holt PJL (1988) Antibodies to type II and type XI collagens: evidence for the formation of antigen-specific as well as cross-reacting antibodies in patients with rheumatoid arthritis. Ann Rheum Dis 47:1008–1013

    CAS  PubMed  Google Scholar 

  96. Clague RB, Morre LJ (1984) IgG and IgM antibody to native type II collagen in rheumatoid arthritis serum and synovial fluid. Arthritis Rheum 27:1370–1377

    CAS  PubMed  Google Scholar 

  97. Klimiuk PS, Clague RB, Grennan DM, Dyer PA, Smeaton I, Harris R (1985) Autoimmunity to native type II collagen — a distinct genetic subset of rheumatoid arthritis. J Rheumatol 12:865–870

    CAS  PubMed  Google Scholar 

  98. Sanders PA, Grennan DM, Klimiuk PS, Clague RB, de Lange CG, Collins I, Dyer PA (1987) Gm allotypes and HLA in rheumatoid arthritis patients with circulating antibodies to native type II collagen. Ann Rheum Dis 46:391–394

    CAS  PubMed  Google Scholar 

  99. Collins I, Morgan K, Clague RB, Brenchley PEC, Holt PJL (1988) IgG subclass distribution of anti-native type II collagen and anti-denatured type II collagen antibodies in patients with rheumatoid arthritis. J Rheumatol 15:770–774

    CAS  PubMed  Google Scholar 

  100. Möttönen T, Hannonen P, Oka M, Rautiainen J, Jokinen I, Arvilommi H, Palosuo T, Aho K (1988) Antibodies against native type II collagen do not precede the clinical onset of rheumatoid arthritis. Arthritis Rheum 31:776–779

    PubMed  Google Scholar 

  101. Banerjee S, Luthra HS, Moore SB, O’Fallon WM (1988) Serum IgG anti-native type II collagen antibodies in rheumatoid arthritis: association with HLA DR4 and lack of clinical correlation. Clin Exp Rheumatol 6:373–380

    CAS  PubMed  Google Scholar 

  102. Tarkowski A, Klareskog L, Carlsten H, Herberts P, Koopman WJ (1989) Secretion of antibodies to types I and II collagen by synovial tissue cells in patients with rheumatoid arthritis. Arthritis Rheum 32:1087–1092

    CAS  PubMed  Google Scholar 

  103. Klareskog L, Holmdahl R, Rubin K (1987) Binding of collagen type II to rheumatoid synovial cells. Scand J Immunol 24:705–714

    Google Scholar 

  104. Wooley PH, Luthra HS, Huse AR, Stuart JM, David CS (1984) Passive transfer of arthritis to mice by injection of human anti-type II collagne antibody. Mayo Clin Proc 59:737–743

    CAS  PubMed  Google Scholar 

  105. Wooley PH, Luthra HS, Krco CJ, Stuart JM, David CS (1984) Type II collagen induced arthritis in mice. II. Passive transfer and suppression by intravenous injection of anti-type II collagen antibody of free native type II collagen. Arthritis Rheum 27:1010–1017

    CAS  PubMed  Google Scholar 

  106. Holmdahl R, Rubin K, Klareskog L, Larsson E, Wigzell H (1986) Characterization of the antibody response in mice with type II collagen-induced arthritis, using monoclonal anti-type II collagen antibodies. Arthritis Rheum 29:400–410

    CAS  PubMed  Google Scholar 

  107. Holmdahl R, Tarkowski A, Nordling C, Rubin K, Klareskog L (1987) Connection between autoimmunity to cartilage type II collagen and rheumatoid factor production. Monogr Allergy 22:71–80

    CAS  PubMed  Google Scholar 

  108. Holmdahl R, Nordling C, Rubin K, Tarkowski A, Klareskog L (1986) Generation of monoclonal rheumatoid factors after immunization with collagen II-anti-collagen II immune complexes. Scand J Immunol 24:197–203

    CAS  PubMed  Google Scholar 

  109. Heinz HP, Rubin K, Laurell AB, Loos M (1989) Common epitopes in C1 q and collagen type II. Mol Immunol 26:163–169

    CAS  PubMed  Google Scholar 

  110. Rolink AG, Radaszkiewicz T, Melchers F (1987) The autoantigen-binding B-cell repertoires of normal and of chronically graft- versus host- diseased mice. J Exp Med 165:1675–1687

    CAS  PubMed  Google Scholar 

  111. Portnoi D, Freitas A, Holmberg D, Bandeira A, Coutinho A (1986) Immunocompetent autoreactive B lymphocytes are activated cycling cells in normal mice. J Exp Med 164:25–35

    CAS  PubMed  Google Scholar 

  112. Jasin HE (1985) Autoantibody specificities of immune complexes sequestered in articular cartilage of patients with rheumatoid arthritis and osteoarthritis. Arthritis Rheum 28:241–248

    CAS  PubMed  Google Scholar 

  113. Trentham DE, Dynesius RA, Rocklin RE, David JR (1978) Cellular sensitivity to collagen in rheumatoid arthritis. N Engl J Med 299:327–332

    CAS  PubMed  Google Scholar 

  114. Stuart JM, Postlethwaite AE, Townes AS, Kang AH (1980) Cell-mediated immunity to collagen and collagen alpha-chains in rheumatoid arthritis and other rheumatic diseases. Am J Med 69:13–18

    CAS  PubMed  Google Scholar 

  115. Solinger AM, Bhatnagar R, Stobo JD (1981) Cellular, molecular, and genetic characteristics of T cell reactivity to collagen in man. Proc Natl Acad Sci USA 78:3877–3881

    CAS  PubMed  Google Scholar 

  116. Trentham DE, Kammer GM, McCune WJ, David JR (1981) Autoimmunity to collagen. A shared feature of psoriatic and rheumatoid arthritis. Arthritis Rheum 24:1363–1369

    CAS  PubMed  Google Scholar 

  117. Kammer GM, Trentham DE (1984) HLA-DR4 is not a requisite for autoimmunity to collagen in rheumatoid arthritis. Arthritis Rheum 27:489–494

    CAS  PubMed  Google Scholar 

  118. Vullo CM, Pesoa SA, Onetti CM, Riera CM (1987) Rheumatoid arthritis and its association with HLA-DR antigens. I. Cell-mediated immune response against connective tissue antigens. J Rheumatol 14:221–225

    CAS  PubMed  Google Scholar 

  119. Golds EE, Stephen IBM, Esdaile JM, Strawczynski Strawczynski, Poole AR (1983) Lymphocyte transformation to connective tissue antigens in adult and juvenile rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, systemic lupus erythematosus, and a non-arthritic control population. Cell Immunol 82:196–209

    CAS  PubMed  Google Scholar 

  120. Londei M, Savill CM, Verhoef A, Brennan F, Leech ZA, Duance V, Maini RN, Feldmann M (1989) Persistence of collagen type-II-specific T-cell clones in the synovial membrane of a patient with rheumatoid arthritis. Proc Natl Acad Sci USA 86:636–640

    CAS  PubMed  Google Scholar 

  121. Ström H, AI-Balaghi S, Möller E (1984) No demonstrable association between HLA DR4 and in vitro collagen reactivity as determined by the production of leukocyte inhibition factor. Tissue Antigens 24:174–183

    PubMed  Google Scholar 

  122. Rowley M, Tait B, Mackay IR, Cunningham T, Phillips B (1986) Collagen antibodies in rheumatoid arthritis. Significance of antibodies to denatured collagen and their association with HLA-DR 4. Arthritis Rheum 29:174–184

    CAS  PubMed  Google Scholar 

  123. Mikecz K, Giant TT, Baron M, Poole AR (1988) Isolation of proteoglycan-specific T lymphocytes from patients with ankylosing spondylitis. Cell Immunol 112:55–63A

    CAS  PubMed  Google Scholar 

  124. Poulter LW, Duke O, Hobbs S, Janossy G, Panayi G (1982) Histochemical discrimination of HLA-DR-positive cell populations in the normal and arthritic synovial lining. Clin Exp Immunol 48:381–388

    CAS  PubMed  Google Scholar 

  125. Klareskog L, Holmdahl R, Rubin K, Victorin à (1985) Different populations of rheumatoid adherent cells mediate activation versus suppression of T lymphocyte proliferation. Arthritis Rheum 28:863–872

    CAS  PubMed  Google Scholar 

  126. Janeway CA, Ron Y, Katz ME (1987) The B cell is the initiating antigen-presenting cell in peripheral lymph nodes. J Immunol 138:1051–1055

    PubMed  Google Scholar 

  127. Schwartz R (1989) Acquisition of immunological self-tolerance. Cell 57:1073–1081

    CAS  PubMed  Google Scholar 

  128. Trentham DE, McCune JW, Susman P, David JR (1980) Autoimmunity to collagen in adjuvant arthritis of rats. J Clin Invest 66:1109–1117

    CAS  PubMed  Google Scholar 

  129. Trentham DE, Dynesius-Trentham RA (1983) Attenuation of an adjuvant arthritis by type II collagen. J Immunol 130:2689–2692

    CAS  PubMed  Google Scholar 

  130. Petty RE, Johnston W, McCormick AQ, Hunt DWC, Rootman J, Rollins DF (1989) Uveitis and arthritis induced by adjuvant: clinical, immunologic and histologic characteristics. J Rheumatol 16:499–505

    CAS  PubMed  Google Scholar 

  131. Goto M, Yoshinoya S, Miyamoto T, Sasano M, Okamoto M, Nishioka K, Terato K, Nagai Y (1988) Stimulation of interleukin-1-alpha and interleukin-1-beta release from human monocytes by cyanogen bromide peptides of type II collagen. Arthritis Rheum 31:1508–1514

    CAS  PubMed  Google Scholar 

  132. Kunken HG, Posnett DN, Pernis B (1983) Anti-immunoglobulins and their idiotypes: are they part of the immune network? Ann N Y Acad Sci 418:324–329

    Google Scholar 

  133. Wolf B, Bashey RI, Newton CD, Jimenez SA (1986) Development of rheumatoid factors and anti-F(ab)2 antibodies in guinea pigs immunized with type II collagen. Int Arch Allergy Appl Immunol 80:214–220

    CAS  PubMed  Google Scholar 

  134. White J, Herman A, Pullen AM, Kubo R, Kappler JW, Marrack P (1989) The V beta-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice. Cell 56:27–35

    CAS  PubMed  Google Scholar 

  135. Cole BC, David CS, Lynch DH, Kartchner DR (1990) The use of transfected fibroblast and transgenic mice establishes that stimulation of T cells by the Mycoplasma arthritidis mitogen is mediated by E-alpha. J Immunol 144:420–424

    CAS  PubMed  Google Scholar 

  136. Cole BC, Kartchner DR, Wells DJ (1990) Stimulation of mouse lymphocytes by a mitogen derived from Mycoplasma arthritidis (MAM). VIII. Selective activation of T cells expressing V-beta T cell receptors from various strains of mice by the “superantigen” MAM. J Immunol 144:425–431

    CAS  PubMed  Google Scholar 

  137. Cole BC, Ward JR, Jones RS, Cahill JF (1971) Chronic proliferative arthritis of mice induced by Mycoplasma arthritidis. I. Induction of disease and histopathologic characteristics. Infect Immun 4:344–355

    CAS  PubMed  Google Scholar 

  138. Banerjee S, Haqqi TM, Luthra HS, Stuart JM, David CS (1988) Possible role of V-beta T-cell receptor genes in susceptibility to collagen-induced arthritis in mice. J Exp Med 167:832–839

    CAS  PubMed  Google Scholar 

  139. Fujita M, Mishima M, Iwabuchi K, Katsume C, Gotohda T, Ogasawara K, Mizuno Y, Good RA, Onoe K (1989) A study of type II collagen-induced arthritis in allogeneic bone marrow chimaeras. Immunology 66:422–427

    CAS  PubMed  Google Scholar 

  140. Goldschmidt T, Holmdahl R, Klareskog L (1988) Depletion of murine T cells by in vivo monoclonal antibody treatment is enhanced by adding an autologous anti-rat kappa chain antibody. J Immunol Methods 111:219–226

    CAS  PubMed  Google Scholar 

  141. Acha-Orbea H, Mitchell DJ, Timmerman L, Wraith DC, Tausch GS, Waldor MK, Zamvil SS, McDevitt HO, Steinman L (1988) Limited heterogeneity of T-cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific intervention. Cell 54:263–273

    CAS  PubMed  Google Scholar 

  142. Klareskog L, Johnell O, Hulth A, Holmdahl R, Rubin K (1986) Reactivity of monoclonal anti-type II collagen antibodies with cartilage and synovial tissue in rheumatoid arthritis and osteoarthritis. Arthritis Rheum 29:730–738

    CAS  PubMed  Google Scholar 

  143. Moreland LW, Stewart T, Gay R, Huang GQ, McGee N, Gay S (1989) Immunohistological demonstration of type-II collagen in synovial fluid phagocytes of osteoarthritis and rheumatoid arthritis patients. Arthritis Rheum 32:1458–1464

    CAS  PubMed  Google Scholar 

  144. Kappler JW, Staerz U, White J, Marrac PC (1988) Self-tolerance eliminates T cells specific for Mis-modified products of the major histocompatibility comlex. Nature 332:35–40

    CAS  PubMed  Google Scholar 

  145. Rammensee HG, Kroschewski R, Frangoulis B (1989) Clonal anergy induced in mature Vbeta6 T lymphocytes on immunizing Mls-1 b mice with Mls-1a-expressing cells. Nature 339:541–544

    CAS  PubMed  Google Scholar 

  146. McDonald HR (1989) T-cell repertoire selection during development. Curr Opinion Immunol 2:199–203

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medical and Physiological Chemistry, Uppsala University, Box 575, S-75123, Uppsala, Sweden

    R. Holmdahl

Authors
  1. R. Holmdahl
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. 2. Medizinische Abteilung Zentrum fü Diagnostik und Therapie rheumatischer Erkrankungen, Krankenhaus der Stadt Wien-Lainz und Ludwig Boltzmann Institut für Rheumatologie und Balneologie, Wolkersbergenstraße 1, A-1130, Wien, Austria

    Josef S. Smolen

  2. Medizinische Klinik III mit Poliklinik und Institut für Klinische Immunologie und Rheumatologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Krankenhausstraße 12, W-8520, Erlangen, Germany

    Joachim R. Kalden

  3. Mathilda and Terence Kennedy Institute of Rheumatology, 6 Bute Gardens, W6 7DW, Hammersmith, London, UK

    Ravinder N. Maini

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Holmdahl, R. (1992). Type-II Collagen in the Pathogenesis of Rheumatoid Arthritis. In: Smolen, J.S., Kalden, J.R., Maini, R.N. (eds) Rheumatoid Arthritis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76189-8_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-76189-8_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76191-1

  • Online ISBN: 978-3-642-76189-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation