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Article
Open AccessThe development of a hiPSC-based platform to identify tissue-dependencies of IDH1 R132H
The application of patient-derived (PD) in vitro tumor models represents the classical strategy for clinical translational oncology research. Using these cellular heterogeneous cultures for the isolation of ca...
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Article
Open AccessAllgemein- und viszeralchirurgische Oberarztkonsile für andere medizinische Disziplinen über 10 Jahre an einem tertiären Zentrum – ist eine schnelle, zeitaufwendige Abarbeitung notwendig?
Die Herausforderungen einer adäquaten, effizienten und rationellen medizinischen Versorgung und Betreuung von Patienten stehen immer im Zusammenhang mit der interprofessionellen Tätigkeit mehrerer Fachdiszipli...
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Article
Open AccessRobotic and laparoscopic liver resection—comparative experiences at a high-volume German academic center
Minimally invasive liver surgery (MILS) is a feasible and safe procedure for benign and malignant tumors. There has been an ongoing debate on whether conventional laparoscopic liver resection (LLR) or robotic ...
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Article
Open AccessR0 resection following chemo (radio)therapy improves survival of primary inoperable pancreatic cancer patients. Interim results of the German randomized CONKO-007± trial
Chemotherapy with or without radiotherapy is the standard in patients with initially nonmetastatic unresectable pancreatic cancer. Additional surgery is in discussion. The CONKO-007 multicenter randomized tria...
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Article
Open AccessA falciform ligament flap surface sealing technique for laparoscopic and robotic-assisted liver surgery
Whether sealing the hepatic resection surface after liver surgery decreases morbidity is still unclear. Nevertheless, various methods and materials are currently in use for this procedure. Here, we describe ou...
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Article
Open AccessConsensus in determining the resectability of locally progressed pancreatic ductal adenocarcinoma – results of the Conko-007 multicenter trial
One critical step in the therapy of patients with localized pancreatic cancer is the determination of local resectability. The decision between primary surgery versus upfront local or systemic cancer therapy s...
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Article
Zehn Jahre Kolonkarzinomchirurgie an tertiärem Zentrum
Qualitätssicherungsstudien leisten einen wertvollen Beitrag zur Optimierung des diagnostischen und therapeutischen Procederes zur stetigen Verbesserung des Patientenoutcomes in der onkochirurgischen Behandlung...
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Article
Predictive value of PD-L1 based on mRNA level in the treatment of stage IV melanoma with ipilimumab
PD-L1 is established as a predictive marker for therapy of non-small cell lung cancer with pembrolizumab. Furthermore, PD-L1 positive melanoma has shown more favorable outcomes when treated with anti-PD1 antib...
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Article
Metastasenchirurgie – anatomische und ethische Grenzen
Aufgrund interdisziplinärer, multimodaler Therapieoptionen ist die Resektion von Metastasen heute bei ausgewählten Patienten mit multilokulärer Metastasierung sinnvoll. Anatomische Grenzen scheinen dabei durch...
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Article
Incisional Hernia: Difficult Cases 2
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Article
Komplikationsvermeidung in der onkologischen Chirurgie der Becken-/Leistenregion
Die Vermeidung peri- und postoperativer Komplikationen bei der chirurgischen Therapie von Tumoren im Beckenbereich und dessen angrenzenden Regionen stellt eine interdisziplinäre Herausforderung dar. In Folge d...
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Article
Open AccessMolecular staging of lymph node-negative colon carcinomas by one-step nucleic acid amplification (OSNA) results in upstaging of a quarter of patients in a prospective, European, multicentre study
Current histopathological staging procedures in colon carcinomas depend on midline division of the lymph nodes with one section of haematoxylin & eosin (H&E) staining only. By this method, tumour deposits outs...
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Chapter and Conference Paper
Differentielle Transfektion auf dem Zellchip zur Hochdurchsatzanalyse parakriner Genwirkungen bei Angiogenese und Tumorinvasion
Invasion and angiogenesis are key processes of tumor growth. Both processes are predominantly regulated in a paracrine manner. Microarray transcriptome analyses of different tumor stages identified many genes ...
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Article
Neoadjuvante Radiochemotherapie des Rektumkarzinoms
Die neoadjuvante Radiochemotherapie ist beim Rektumkarzinom mittlerweile etabliert. Die Indikation stellt sich, wenn primär eine R0-Resektion (wahrscheinlich) nicht zu erreichen ist, das Risiko eines lokoregio...
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Chapter and Conference Paper
Comparative proteomics-analysis for the isolation of markers for metastasis of the colorectal carcinoma
Colorectal carcinoma is the second most common malignancy among men and women worldwide. Molecular markers that enable to identify metastatic processes are needed urgently. An early identification of patients ...
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Chapter and Conference Paper
Inflammation-associated inhibition of angiogenesis in colorectal carcinoma: molecular mechanisms and prognostic impact
Proinflammatory cytokines (IL-1β, TNF-α and IFN-γ) inhibit proliferation and invasion of endothelial cells. We identified the large GTPase guanylate binding protein-1 (GBP-1) as the intracellular mediator of t...
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Chapter and Conference Paper
Comparative analysis of endothelial cells and fibroblasts from human colorectal cacinoma
Progression of colorectal carcinoma is strongly associated with angiogenesis and other desmoplastic reactions, such as inflammation in the surrounding tissue. In order to elucidate the impact of the carcinoma ...
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Chapter and Conference Paper
Familiäre adenomatose Polyposis coli (FAP) assoziierte Schilddrüsen-Karzinome / Familial Adenomatous Polyposis Coli (FAP) Associated Carcinoma of the Thyroid Gland
Papillary thyroid carcinoma is one extracolonic manifestation affecting about 1 – 2% of patients with familial adenomatous polyposis. Concerning our FAP-register with 320 patients we found out four patients wi...
