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  1. No Access

    Article

    Structural proteins of Kaposi’s sarcoma-associated herpesvirus antagonize p53-mediated apoptosis

    The tumor suppressor p53 is a central regulatory molecule of apoptosis and is commonly mutated in tumors. Kaposi’s sarcoma-associated herpesvirus (KSHV)-related malignancies express wild-type p53. Accordingly,...

    P Chudasama, A Konrad, R Jochmann, B Lausen, P Holz, E Naschberger, F Neipel… in Oncogene (2015)

  2. No Access

    Chapter and Conference Paper

    Differentielle Transfektion auf dem Zellchip zur Hochdurchsatzanalyse parakriner Genwirkungen bei Angiogenese und Tumorinvasion

    Invasion and angiogenesis are key processes of tumor growth. Both processes are predominantly regulated in a paracrine manner. Microarray transcriptome analyses of different tumor stages identified many genes ...

    E. Kuhn, A. Konrad, E. Naschberger, R.S. Croner… in Chirurgisches Forum und DGAV Forum 2010 (2010)

  3. No Access

    Chapter and Conference Paper

    Comparative proteomics-analysis for the isolation of markers for metastasis of the colorectal carcinoma

    Colorectal carcinoma is the second most common malignancy among men and women worldwide. Molecular markers that enable to identify metastatic processes are needed urgently. An early identification of patients ...

    A. C. Sauermann, M. Thurau, R. S. Croner… in Chirurgisches Forum und DGAV Forum 2009 (2009)

  4. No Access

    Chapter and Conference Paper

    Inflammation-associated inhibition of angiogenesis in colorectal carcinoma: molecular mechanisms and prognostic impact

    Proinflammatory cytokines (IL-1β, TNF-α and IFN-γ) inhibit proliferation and invasion of endothelial cells. We identified the large GTPase guanylate binding protein-1 (GBP-1) as the intracellular mediator of t...

    Prof. Dr. Dr. M. Stürzl, K. Weinländer… in Chirurgisches Forum und DGAV Forum 2009 (2009)

  5. No Access

    Chapter and Conference Paper

    Comparative analysis of endothelial cells and fibroblasts from human colorectal cacinoma

    Progression of colorectal carcinoma is strongly associated with angiogenesis and other desmoplastic reactions, such as inflammation in the surrounding tissue. In order to elucidate the impact of the carcinoma ...

    Dr. med. V. S. A. Schellerer, R. S. Croner… in Chirurgisches Forum und DGAV Forum 2009 (2009)

  6. No Access

    Chapter and Conference Paper

    Systematische Untersuchung von Kombinationswirkungen der HHV-8-Gene auf die NF-κB-Aktivierung

    Activation of nuclear factor-kappa B (NF-κB), a key regulatory molecule in inflammation, is essential for survival of Human Herpesvirus (HHV)-8-infected cells. Using reverse transfection cell arrays (RTCA) as ...

    Andreas Konrad, E. Wies, M. Thurau, G. Sander, R. Leubert… in Chirurgisches Forum 2008 (2008)

  7. No Access

    Chapter and Conference Paper

    Charakterisierung molekularer Mechanismen der anti-angiogenen Aktivität von GBP-1 in Endothelzellen

    Human guanylate binding protein-1 (GBP-1) exerts potent anti-angiogenic properties in human endothelial cells (EC) through inhibition of EC invasiveness and proliferation. To date, the molecular mechanisms of ...

    Kristina Weinländer, E. Naschberger, M. H. Lehmann… in Chirurgisches Forum 2008 (2008)