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Article
Open AccessFactors associated with antiretroviral treatment adherence among people living with HIV in Guangdong Province, China: a cross sectional analysis
Understanding factors associated with antiretroviral treatment (ART) adherence is crucial for ART success among people living with HIV (PLHIV) in the “test and treat” era. Multiple psychosocial factors tend to...
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Article
Open AccessEZH2 G553C significantly increases the risk of brain metastasis from lung cancer due to salt bridge instability
The incidence and mortality of lung cancer is the highest in China and the world. Brain is the most common distant metastasis site of lung cancer. Its transfer mechanism and predictive biomarkers are still unc...
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Article
Analysis of serum metabolome of laborers exposure to welding fume
Welding fume exposure is inevitable of welding workers and poses a severe hazard to their health since welding is a necessary industrial process. Thus, preclinical diagnostic symptoms of worker exposure are of...
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Article
Selective deficiency of UCP-1 and adropin may lead to different subtypes of anti-neutrophil cytoplasmic antibody-associated vasculitis
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic autoimmune disease that is prone to respiratory and renal failures. Its major target antigens are serine protease 3 (PR3) a...
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Article
Immune disguise: the mechanisms of Neu5Gc inducing autoimmune and transplant rejection
Organ (stem cell) transplantation is the most effective treatment for advanced organ failure. Neu5Gc (N-hydroxyacetylneuraminic acid) is a pathogenic non-human sialic acid, which is very similar to the molecul...
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Article
Limb-bud and Heart (LBH) mediates proliferation, fibroblast-to-myofibroblast transition and EMT-like processes in cardiac fibroblasts
Cardiac fibrosis is an important pathological change after myocardial infarction (MI). Its progression is essential for post-MI infarct healing, during which transforming growth factor beta1 (TGF-β1) plays a c...
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Article
CGRP-Mediated Prolactin Upregulation: a Possible Pathomechanism in IgG4-Related Disease
Similar to other immune-mediated diseases, IgG4-related disease (IgG4-RD) is the disease that develops in genetically susceptible individuals exposed to external or endogenous antigens. In the present study, i...
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Effects of Environmental Endocrine-Disrupting Chemicals on Female Reproductive Health
Environmental endocrine-disrupting chemicals (EDCs) are xenobiotic compounds that are frequently contacted in daily life. With the species and quantity of substances created and utilized by human beings signif...
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Article
Open AccessPRSS1 mutation: a possible pathomechanism of pancreatic carcinogenesis and pancreatic cancer
Previous studies revealed somatic mutations of the cationic trypsinogen gene (PRSS1) in patients with chronic pancreatitis and pancreatic cancer. However, whether PRSS1 mutations trigger pancreatic cancer and/...
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Article
Delicaflavone induces autophagic cell death in lung cancer via Akt/mTOR/p70S6K signaling pathway
Searching for potential anticancer agents from natural sources is an effective strategy for develo** novel chemotherapeutic agents. In this study, data supporting the in vitro and in vivo anticancer effects ...
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Article
Human epididymis protein 4 expression positively correlated with miR-21 and served as a prognostic indicator in ovarian cancer
Ovarian cancer is the most common cause of gynecological malignancy-related mortality. Human epididymis protein 4 (HE4) is a useful biomarker for ovarian cancer when either used alone or in combination with ca...
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Article
PRSS1 mutations and the proteinase/antiproteinase imbalance in the pathogenesis of pancreatic cancer
This study aimed to investigate the mutations in the serine protease 1 gene (PRSS1) and the imbalance between trypsin and α1-antitrypsin in patients with pancreatic cancer. Polymerase chain reaction (PCR) was per...
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Article
Open AccessLimb-bud and Heart (LBH) Functions as a Tumor Suppressor of Nasopharyngeal Carcinoma by Inducing G1/S Cell Cycle Arrest
Epstein–Barr virus-encoded latent membrane protein-1 (LMP1) plays a fundamental role in the malignant transformation of nasopharyngeal carcinoma (NPC), although the mechanism is not well understood. Here, we s...
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Article
High Serum Trypsin Levels and the −409 T/T Genotype of PRSS1 Gene Are Susceptible to Neonatal Sepsis
Neonatal sepsis remains an important and common cause of morbidity and mortality among newborn infants, especially in develo** countries. The aim of the present study was to determine whether serum trypsin l...
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Article
The −409 C/T Genotype of PRSS1 Protects Against Pancreatic Cancer in the Han Chinese Population
The high mortality rate of pancreatic cancer is a bottleneck for further treatment with long-term efficacy. Thus, it is urgent to identify new methods to accurately predict the early onset of pancreatic cancer...
