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Open AccessParametric investigation of railway fastenings into the formation and mitigation of short pitch corrugation
Short pitch corrugation has been a problem for railways worldwide over one century. In this paper, a parametric investigation of fastenings is conducted to understand the corrugation formation mechanism and ga...
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Article
Open AccessB7H3 targeting gold nanocage pH-sensitive conjugates for precise and synergistic chemo-photothermal therapy against NSCLC
The combination of drug delivery with immune checkpoint targeting has been extensively studied in cancer therapy. However, the clinical benefit for patients from this strategy is still limited. B7 homolog 3 pr...
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Chapter
Electrochemical Biosensors for Hepatic and Cardiac Biomarkers Detection
Hepatic and cardiac diseases are two of the main serious diseases harming people’s health and even life. Electrochemical biosensors, which have sufficient sensitivity, high specificity, simple operation proces...
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Chapter
Electrochemical Biosensors for Neurotransmitters Detection
Neurotransmitters (NTs) are related to various brain functions. Furthermore, abnormal NT levels are implicated in many psychotic, physical, and neurodegenerative diseases, including schizophrenia, depression, ...
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Chapter
Introduction
Whole blood, as one of the most significant biological fluids, maintains the normal functioning of various organs and tissues in the human body. The physicochemical changes of different components in whole blo...
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Book
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Chapter
Electrochemical Biosensors and the Signaling
An electrochemical biosensor is a type of sensor that uses biological materials as the sensitive component, electrodes as the conversion element, and current, potential or resistance as detectable characterist...
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Article
Open AccessImpaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration
Although skeletal progenitors provide a reservoir for bone-forming osteoblasts, the major energy source for their osteogenesis remains unclear. Here, we demonstrate a requirement for mitochondrial oxidative ph...
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Article
Open AccessIrisin enhances chondrogenic differentiation of human mesenchymal stem cells via Rap1/PI3K/AKT axis
Human mesenchymal stem cells (hMSCs) have been proven to have inherent chondrogenic differentiation potential, which appears to be used in cartilage regeneration. Increasing evidence suggests that irisin enhan...
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Chapter and Conference Paper
A Finite Element Thermomechanical Analysis of Polygonal Wear
Polygonal wear is a common type of damage on the railway wheel tread, which could induce wheel-rail impacts and further components failure. This study presents a finite element (FE) thermomechanical model to i...
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Article
Correlation between continuation of glucocorticoid treatment and risk of femoral head collapse
To evaluate the correlation between continuation of glucocorticoid (GC) treatment and risk of femoral head collapse in patients with glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) after hip-...
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Article
Open AccessA deep learning diagnostic platform for diffuse large B-cell lymphoma with high accuracy across multiple hospitals
Diagnostic histopathology is a gold standard for diagnosing hematopoietic malignancies. Pathologic diagnosis requires labor-intensive reading of a large number of tissue slides with high diagnostic accuracy eq...
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Article
Open AccessTherapeutic inhibition of FcγRIIb signaling targets leukemic stem cells in chronic myeloid leukemia
Despite the successes achieved with molecular targeted inhibition of the oncogenic driver Bcr-Abl in chronic myeloid leukemia (CML), the majority of patients still require lifelong tyrosine kinase inhibitor (T...
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Article
Nitrogen-doped carbon dots as a ratiometric fluorescent probe for determination of the activity of acid phosphatase, for inhibitor screening, and for intracellular imaging
The author describe a method for preparation of green fluorescent nitrogen-doped carbon dots (N-CDs) through hydrothermal treatment of a mixture of lotus leaf juice and ethylenediamine (EDA). The N-CDs have un...
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Book
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Chapter
Leukemia Stem Cells in Chronic Myeloid Leukemia
Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder characterized by a chromosome translocation that generates the BCR-ABL oncogene encoding a constitutively activated tyrosine kinase. Altho...
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Chapter
Sandwich Assay for Pathogen and Cells Detection
Sandwich assay biosensors make it possible to detect bacterial pathogens and cancer cells at extremely low level. In this chapter, we have summarized the recent developments of sandwich assay for pathogen and ...
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Chapter
Electrochemical Sandwich Assays for Protein Detection
Rapid, sensitive, and selective detection of proteins biomarker plays a very important role in early diagnostics of diseases and global health. Toward this goal, numerous researchers have devoted great efforts...
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Article
Fluorescent turn-off competitive immunoassay for biotin based on hydrothermally synthesized carbon dots
Blue fluorescent carbon dots (C-Dots) were synthesized by a hydrothermal process using citric acid and polyethylene-polyamines as the precursors. The C-dots display strong fluorescence, excellent water solubil...
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Article
Delicaflavone induces autophagic cell death in lung cancer via Akt/mTOR/p70S6K signaling pathway
Searching for potential anticancer agents from natural sources is an effective strategy for develo** novel chemotherapeutic agents. In this study, data supporting the in vitro and in vivo anticancer effects ...
