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  1. Article

    Open Access

    Image-based hemodynamic simulations for intracranial aneurysms: the impact of complex vasculature

    Hemodynamics play an important role in the assessment of intracranial aneurysm (IA) development and rupture risk. The purpose of this study was to examine the impact of complex vasculatures onto the intra-vess...

    Franziska Gaidzik, Jana Korte in International Journal of Computer Assisted… (2024)

  2. Article

    Open Access

    Multimodal exploration of the intracranial aneurysm wall

    Intracranial aneurysms (IAs) are pathological changes of the intracranial vessel wall, although clinical image data can only show the vessel lumen. Histology can provide wall information but is typically restr...

    Annika Niemann, Riikka Tulamo, Eliisa Netti in International Journal of Computer Assisted… (2023)

  3. Article

    Open Access

    Is Accurate Lumen Segmentation More Important than Outlet Boundary Condition in Image-Based Blood Flow Simulations for Intracranial Aneurysms?

    Image-based blood flow simulations are increasingly used to investigate the hemodynamics in intracranial aneurysms (IAs). However, a strong variability in segmentation approaches as well as the absence of indi...

    Jana Korte, Samuel Voß, Gábor Janiga in Cardiovascular Engineering and Technology (2023)

  4. Article

    Open Access

    Long-term outcome of patients with vaccine-induced immune thrombotic thrombocytopenia and cerebral venous sinus thrombosis

    We present the long-term outcomes of 44 patients who developed cerebral venous sinus thrombosis after vaccination with the adenoviral vector ChAdOx1 nCoV-19 COVID-19 vaccine. Assessment of the Extended Glasgow...

    Sarah Kehr, Philipp Berg, Susanne Müller, Sarah A. Fiedler, Britta Meyer in npj Vaccines (2022)

  5. Article

    Open Access

    Virtual embolization for treatment support of intracranial AVMs using an interactive desktop and VR application

    The treatment of intracranial arteriovenous malformations (AVM) is challenging due to their complex anatomy. For this vessel pathology, arteries are directly linked to veins without a capillary bed in between....

    Ulrike Sprengel, Patrick Saalfeld in International Journal of Computer Assisted… (2021)

  6. Article

    Open Access

    Luminal enhancement in intracranial aneurysms: fact or feature?—A quantitative multimodal flow analysis

    Intracranial aneurysm (IA) wall enhancement on post-contrast vessel wall magnetic resonance imaging (VW-MRI) is assumed to be a biomarker for vessel wall inflammation and aneurysm instability. However, the exa...

    Franziska Gaidzik, Mariya Pravdivtseva in International Journal of Computer Assisted… (2021)

  7. Article

    Open Access

    VICTORIA: VIrtual neck Curve and True Ostium Reconstruction of Intracranial Aneurysms

    For the status evaluation of intracranial aneurysms (IAs), morphological and hemodynamic parameters can provide valuable information. For their extraction, a separation of the aneurysm sac from its parent vess...

    Philipp Berg, Benjamin Behrendt, Samuel Voß in Cardiovascular Engineering and Technology (2021)

  8. Article

    Open Access

    Complex wall modeling for hemodynamic simulations of intracranial aneurysms based on histologic images

    For the evaluation and rupture risk assessment of intracranial aneurysms, clinical, morphological and hemodynamic parameters are analyzed. The reliability of intracranial hemodynamic simulations strongly depen...

    Annika Niemann, Samuel Voß, Riikka Tulamo in International Journal of Computer Assisted… (2021)

  9. Article

    Open Access

    Multimodal validation of focal enhancement in intracranial aneurysms as a surrogate marker for aneurysm instability

    Circumferential enhancement on MR vessel wall imaging has been proposed as a biomarker of a higher risk of rupture in intracranial aneurysms. Focal enhancement is frequently encountered in unruptured aneurysms...

    Naomi Larsen, Charlotte Flüh, Sylvia Saalfeld, Samuel Voß, Georg Hille in Neuroradiology (2020)

  10. No Access

    Article

    Flow-splitting-based computation of outlet boundary conditions for improved cerebrovascular simulation in multiple intracranial aneurysms

    Image-based hemodynamic simulations have great potential for precise blood flow predictions in intracranial aneurysms. Due to model assumptions and simplifications with respect to boundary conditions, clinical...

    Sylvia Saalfeld, Samuel Voß, Oliver Beuing in International Journal of Computer Assisted… (2019)

  11. No Access

    Article

    Multiple Aneurysms AnaTomy CHallenge 2018 (MATCH)—phase II: rupture risk assessment

    Assessing the rupture probability of intracranial aneurysms (IAs) remains challenging. Therefore, hemodynamic simulations are increasingly applied toward supporting physicians during treatment planning. Howeve...

    Philipp Berg, Samuel Voß, Gábor Janiga in International Journal of Computer Assisted… (2019)

  12. Article

    Open Access

    Evaluation of flow changes after telescopic stenting of a giant fusiform aneurysm of the vertebrobasilar junction

    The use of flow-diverters for non-saccular cerebral posterior circulation aneurysms requires complex deployment techniques and is associated with high mortality and morbidity. Therefore, further studies are re...

    Sergey Sindeev, Jan Stephan Kirschke, Sascha Prothmann in BioMedical Engineering OnLine (2019)

  13. Article

    Open Access

    Multiple Aneurysms AnaTomy CHallenge 2018 (MATCH): uncertainty quantification of geometric rupture risk parameters

    Geometric parameters have been proposed for prediction of cerebral aneurysm rupture risk. Predicting the rupture risk for incidentally detected unruptured aneurysms could help clinicians in their treatment dec...

    Leonid Goubergrits, Florian Hellmeier, Jan Bruening in BioMedical Engineering OnLine (2019)

  14. Article

    Open Access

    Real-World Variability in the Prediction of Intracranial Aneurysm Wall Shear Stress: The 2015 International Aneurysm CFD Challenge

    Image-based computational fluid dynamics (CFD) is widely used to predict intracranial aneurysm wall shear stress (WSS), particularly with the goal of improving rupture risk assessment. Nevertheless, concern ha...

    Kristian Valen-Sendstad, Aslak W. Bergersen in Cardiovascular Engineering and Technology (2018)

  15. No Access

    Article

    Multiple Aneurysms AnaTomy CHallenge 2018 (MATCH): Phase I: Segmentation

    Advanced morphology analysis and image-based hemodynamic simulations are increasingly used to assess the rupture risk of intracranial aneurysms (IAs). However, the accuracy of those results strongly depends on...

    Philipp Berg, Samuel Voß, Sylvia Saalfeld in Cardiovascular Engineering and Technology (2018)

  16. No Access

    Article

    Semiautomatic neck curve reconstruction for intracranial aneurysm rupture risk assessment based on morphological parameters

    Morphological parameters of intracranial aneurysms (IAs) are well established for rupture risk assessment. However, a manual measurement is error-prone, not reproducible and cumbersome. For an automatic extrac...

    Sylvia Saalfeld, Philipp Berg in International Journal of Computer Assisted… (2018)

  17. No Access

    Article

    Multiple intracranial aneurysms: a direct hemodynamic comparison between ruptured and unruptured vessel malformations

    Despite numerous studies addressing the rupture risk of intracranial aneurysms that have been published, the assessment thereof still remains challenging. Image-based simulations enable a precise prediction of...

    Philipp Berg, Oliver Beuing in International Journal of Computer Assisted… (2018)