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Article
Open AccessMultimodal exploration of the intracranial aneurysm wall
Intracranial aneurysms (IAs) are pathological changes of the intracranial vessel wall, although clinical image data can only show the vessel lumen. Histology can provide wall information but is typically restr...
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Article
Open AccessImmunoliposomes for detection of rupture-prone intracranial aneurysms
It is estimated that significant (3.2%) of population carries intracranial aneurysm (IA). An increasing number of imaging studies have caused that the chance of finding an incidental aneurysm is becoming more ...
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Article
Open AccessLymphatic vessels are present in human saccular intracranial aneurysms
Saccular intracranial aneurysm (sIA) rupture leads to subarachnoid haemorrhage and is preceded by chronic inflammation and atherosclerotic changes of the sIA wall. Increased lymphangiogenesis has been detected...
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Article
Open AccessComplex wall modeling for hemodynamic simulations of intracranial aneurysms based on histologic images
For the evaluation and rupture risk assessment of intracranial aneurysms, clinical, morphological and hemodynamic parameters are analyzed. The reliability of intracranial hemodynamic simulations strongly depen...
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Article
Interactive exploration of a 3D intracranial aneurysm wall model extracted from histologic slices
Currently no detailed in vivo imaging of the intracranial vessel wall exists. Ex vivo histologic images can provide information about the intracranial aneurysm (IA) wall composition that is useful for the unde...
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Article
Open AccessLipid accumulation, lipid oxidation, and low plasma levels of acquired antibodies against oxidized lipids associate with degeneration and rupture of the intracranial aneurysm wall
Rupture of a saccular intracranial aneurysm (sIA) causes an often fatal subarachnoid hemorrhage (SAH). Why some sIAs rupture remains unknown. Since sIA walls bear some histological similarities with early athe...
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Article
Saccular intracranial aneurysm: pathology and mechanisms
Saccular intracranial aneurysms (sIA) are pouch-like pathological dilatations of intracranial arteries that develop when the cerebral artery wall becomes too weak to resist hemodynamic pressure and distends. S...
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Article
Isolation, culture, and characterization of smooth muscle cells from human intracranial aneurysms
Smooth muscle cells (SMCs) play a critical role in the vascular wall and also participate in vascular repair mechanisms. Dysfunction of SMCs may also contribute to the formation of intracranial aneurysms (IAs)...
