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Article
Open AccessLeveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries
We develop a method, SBayesRC, that integrates genome-wide association study (GWAS) summary statistics with functional genomic annotations to improve polygenic prediction of complex traits. Our method is scala...
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Article
Open AccessMaternal aging increases offspring adult body size via transmission of donut-shaped mitochondria
Maternal age at childbearing has continued to increase in recent decades. However, whether and how it influences offspring adult traits are largely unknown. Here, using adult body size as the primary readout, ...
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Article
Open AccessGenetic control of RNA splicing and its distinct role in complex trait variation
Most genetic variants identified from genome-wide association studies (GWAS) in humans are noncoding, indicating their role in gene regulation. Previous studies have shown considerable links of GWAS signals to...
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Article
Open AccessDissection of complicate genetic architecture and breeding perspective of cottonseed traits by genome-wide association study
Cottonseed is one of the most important raw materials for plant protein, oil and alternative biofuel for diesel engines. Understanding the complex genetic basis of cottonseed traits is requisite for achieving ...
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Article
Open AccessDissection of genetic architecture of rice plant height and heading date by multiple-strategy-based association studies
**eyou9308 is a certified super hybrid rice cultivar with a high grain yield. To investigate its underlying genetic basis of high yield potential, a recombinant inbred line (RIL) population derived from the cr...
