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  1. Article

    Behavioral, Hormonal, Inflammatory, and Metabolic Effects Associated with FGF21-Pathway Activation in an ALS Mouse Model

    In amyotrophic lateral sclerosis (ALS), motor neuron degeneration occurs simultaneously with systemic metabolic dysfunction and neuro-inflammation. The fibroblast growth factor 21 (FGF21) plays an important ro...

    J. B. Delaye, D. Lanznaster, C. Veyrat-Durebex, A. Fontaine, G. Bacle… in Neurotherapeutics (2021)

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  2. Article

    Open Access

    The specific metabolome profiling of patients infected by SARS-COV-2 supports the key role of tryptophan-nicotinamide pathway and cytosine metabolism

    The biological mechanisms involved in SARS-CoV-2 infection are only partially understood. Thus we explored the plasma metabolome of patients infected with SARS-CoV-2 to search for diagnostic and/or prognostic ...

    H. Blasco, C. Bessy, L. Plantier, A. Lefevre, E. Piver, L. Bernard… in Scientific Reports (2020)

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  3. No Access

    Article

    Causative Genes in Amyotrophic Lateral Sclerosis and Protein Degradation Pathways: a Link to Neurodegeneration

    Amyotrophic lateral sclerosis (ALS) is a disease caused by the degeneration of motor neurons (MNs) leading to progressive muscle weakness and atrophy. Several molecular pathways have been implicated, such as g...

    C. Maurel, A. Dangoumau, S. Marouillat, C. Brulard, A. Chami… in Molecular Neurobiology (2018)

  4. Article

    Open Access

    Lipidomics Reveals Cerebrospinal-Fluid Signatures of ALS

    Amyotrophic lateral sclerosis (ALS), the commonest adult-onset motor neuron disorder, is characterized by a survival span of only 2–5 years after onset. Relevant biomarkers or specific metabolic signatures wou...

    H. Blasco, C. Veyrat-Durebex, C. Bocca, F. Patin, P. Vourc’h… in Scientific Reports (2017)

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  5. No Access

    Article

    A decrease in blood cholesterol after gastrostomy could impact survival in ALS

    Although the global benefits of gastrostomy have been proven in amyotrophic lateral sclerosis (ALS), the impact on biological parameters has not been explored yet. The aim of this preliminary work was to evalu...

    H Blasco, F Patin, S Molinier, P Vourc'h… in European Journal of Clinical Nutrition (2017)

  6. No Access

    Article

    Advances in Cellular Models to Explore the Pathophysiology of Amyotrophic Lateral Sclerosis

    Amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disorder, is fatal for most patients less than 3 years from when the first symptoms appear. The aetiologies for sporadic and most f...

    C. Veyrat-Durebex, P. Corcia, A. Dangoumau, F. Laumonnier… in Molecular Neurobiology (2014)

  7. No Access

    Article

    Xq27 FRAXA Locus is a Strong Candidate for Dyslexia: Evidence from a Genome-Wide Scan in French Families

    Dyslexia is a frequent neurodevelopmental learning disorder. To date, nine susceptibility loci have been identified, one of them being DYX9, located in Xq27. We performed the first French SNP linkage study fol...

    M. Huc-Chabrolle, C. Charon, A. Guilmatre, P. Vourc’h, G. Tripi… in Behavior Genetics (2013)