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Chapter
Regulation of Lacrimal Gland Immune Responses
The purpose of this review is: (1) to consider the relationship of the lacrimal gland to the mucosal network and general factors regulating lacrimal gland immune responses, (2) to present current data from sel...
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Chapter
Optimising the expression of antibody in tears: manipulation of the common mucosal immune response?
The IgA in rat tears (200ug/ml) is supplied almost entirely by plasma cells in the lachrymal gland. We researched methods to elicit IgA responses in tears, with the aim of optimising vaccination protocols. Ser...
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Chapter
Characterisation of the lymphocyte-glandular mucosal tissue interaction using an in vitro adherence assay
The in vitro adherence of lymphocytes to lacrimal gland (LG) tissue was compared to high endothelial venules (HEV) of cervical lymph node (CLN) tissue. Thoracic duct (TDL) and mesenteric lymph node (MLN) lymphocy...
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Chapter
Characterization and Mitogenic Responsiveness of Murine Mammary Gland Mononuclear Cells
Lymphocyte traffic from subcompartments of intestinal mucosal associated lymphoid tissue (MALT) to mammary (1), salivary (2) and lacrimal (3) glands is a characteristic feature of the mucosal network. With res...
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Chapter
Optical Metrology at Loughborough University
The main objective of the laser group in the Mechanical Engineering Department at Loughborough University is to develop methods of extracting data by remote means that can be used by industry. Three such whole...
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Article
Biochemical mediators of the effects of mechanical forces and electric currents on mineralized tissues
Cyclic nucleotides (cAMP and cGMP) and prostaglandin E (PGE) have been implicated as possible mediators of the effects of external stimuli on bone cells. The objective of this study was to determine changes in...
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Article
Guanosine 3′,5′-monophosphate in bone: Microscopic visualization by an immuno-histochemical technique
Guanosine 3′,5′-monophosphate (cyclic GMP, cGMP) was localized in bone cells by the use of an immunoglobulin-enzyme bridge method. We observed that in cat alveolar bone most osteoblasts did not stain for cGMP,...
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Article
Cellular localization and concentration of bone cyclic nucleotides in response to acute PTE administration
The cyclic AMP and cyclic GMP concentrations of alveolar bone of control and PTE-treated cats were measured by chemical and immunohistochemical methods. In the PTE-treated animals, alveolar bone osteoblasts st...
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Article
Cellular localization of cyclic AMP in periodontal tissues during experimental tooth movement in cats
Using an immune-histochemical method, cyclic AMP was localized in cells of periodontal tissues in orthodontically-treated cats. Sixteen cats were treated for periods ranging from 1 hour to 4 weeks. Fresh, froz...
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Article
Demonstration of cyclic AMP in bone cells by immuno-histochemical methods
By utilizing immunohistochemical procedures it was possible to locate bone cells that contained adenosine 3′5′-monophosphate (cyclic AMP) in frozen, undecalcified cat jaw sections. An immunoglobulin-enzyme bri...
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Article
Evidence for the induction of two antibodies with identical combining sites in outbred animals
THE mechanism by which the immune system produces an apparently limitless array of antibodies in response to a variety of antigenic stimuli remains an unresolved biological question. Primary structural analysi...
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Chapter
The Induction and Characterization of Secretory IgA Antibodies
In addition to humoral immunity, which is characterized by the presence of circulating antibody, a second distinct type of immunity involves the localized production of secretory antibodies (reviews 1,2,3). Nu...
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Article
Molecular Restriction of Anti-hapten Antibody elicited in Neonatal Rabbits
THE origin of the diversity of antibody combining sites is one of the crucial questions of immunology. Many workers, ho** for evidence from structural studies of homogeneous antibodies, have attempted to eli...
