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Article
Open AccessProspects for observing and localizing gravitational-wave transients with Advanced LIGO, Advanced Virgo and KAGRA
We present our current best estimate of the plausible observing scenarios for the Advanced LIGO, Advanced Virgo and KAGRA gravitational-wave detectors over the next several years, with the intention of providi...
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Article
Open AccessProspects for observing and localizing gravitational-wave transients with Advanced LIGO, Advanced Virgo and KAGRA
We present possible observing scenarios for the Advanced LIGO, Advanced Virgo and KAGRA gravitational-wave detectors over the next decade, with the intention of providing information to the astronomy community...
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Article
Open AccessProspects for Observing and Localizing Gravitational-Wave Transients with Advanced LIGO and Advanced Virgo
We present a possible observing scenario for the Advanced LIGO and Advanced Virgo gravitational-wave detectors over the next decade, with the intention of providing information to the astronomy community to fa...
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Article
A to X of B cells
B Lymphocytes in Human Disease.
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Article
Co-operative nature of N-glycosylation of proteins at multiple sites: evidence from studies with tunicamycin
The pattern of glycosylation of newly synthesized human and routine immunoglobulin μ-chains varies according to the degree of inhibition of N-glycosylation effected by using the antibiotic tunicamycin. Tunicam...
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Article
A common mechanism for the synthesis of membrane and secreted immunoglobulin α, γ and μ chains
Immunoglobulins serve as both secreted effector antibodies and antigen receptors bound to the membrane of lymphocytes. Each newly generated B lymphocyte expresses membrane IgM and subsequently co-expresses mem...
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Article
Three-receptor, clonal expansion model for selection of self-recognition in the thymus
The postulate is made that dual recognition by T lymphocytes is due to two types of receptor, one encoded by antibody genes and one by a distinct multigene family with simple rules for expression. This postula...
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Article
Flavour of gene expression
Control of Gene Expression.
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Article
Inheritance of an isoelectrically focused spectrotype linked to theIg-1 b allotype
The primary anti-NP response in C57BL/6 and CBA mice was analyzed by isoelectric focusing. Antibody responses in C57 mice were restricted in heterogeneity and over 80 % of this strain shared an isoelectric foc...
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Chapter
Germ line basis for antibody diversity
Each antibody polypeptide chain is the product of a gene pair comprising one constant (C) gene coding for that portion of the chain common to all chains of the same type and one variable (V) gene coding for th...
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Chapter
mRNA for H and L Chains of Immunoglobulin: Specific Control of H-Chain Production
Messenger RNA (mRNA) was postulated to exist in prokaryotic systems by Jacob and Monod (1961) on the basis of genetic evidence. Extensive studies since that time have proven the universality of the transfer of...
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Article
Dominance of a Cell Clone Forming Antibody to DNP
IN the previous paper1 we described the history of a cell clone (E9) synthesizing a single species of anti-DNP. The original expansion of the clone and its strong proliferative capacity during the first few trans...
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Article
Senescence of an Antibody-forming Cell Clone
SELECTION and propagation of a single antibody-forming cell clone has been effected by serial transfer of limited numbers of spleen cells into irradiated syngeneic mice1. Original spleen cell donors were immunize...
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Article
Cell Surveillance Model for Lymphocyte Cooperation
A model is proposed for clonal proliferation and antibody production of B lymphocytes. It suggests that changes in the B cell surface due to specific antigen binding are detected by T lymphocytes, which then s...
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Article
Molecular Restriction of Anti-hapten Antibody elicited in Neonatal Rabbits
THE origin of the diversity of antibody combining sites is one of the crucial questions of immunology. Many workers, ho** for evidence from structural studies of homogeneous antibodies, have attempted to eli...
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Article
Molecular Immunology
Biochemistry of Antibodies
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Article
Isoelectric Focusing in Polyacrylamide Gel and its Application to Immunoglobulins
THE principle of isoelectric fractionation was applied to the separation of amino-acids as early as 1912 by Ikeda and Suzuki (Japanese patent quoted in ref. 8), but the technique did not become practical for t...
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Article
Professor Richard S. Schweet