13 Result(s)
within
P Rougier
Biomedicine, general
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Article
Open AccessEarly detection of recurrence by 18FDG-PET in the follow-up of patients with colorectal cancer
We assessed the potential benefits of including systematic 18fluorodeoxyglucose positron emission tomography (FDG-PET) for detecting tumour recurrence in a prospective randomised trial. Patients (N=130) who had u...
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Article
Open AccessArterial phase enhancement and body mass index are predictors of response to chemoembolisation for liver metastases of endocrine tumours
Transcatheter arterial chemoembolisation (TACE) has been reported to be an efficient treatment of liver metastases of endocrine tumours in short series of patients. However, several factors seem to affect its ...
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Article
Open AccessLoss of heterozygosity on 10q and mutational status of PTEN and BMPR1A in colorectal primary tumours and metastases
We investigated the possible role of chromosome 10q losses in colorectal cancer metastasis by carrying out an allelic imbalance study on a series of microsatellite instability-negative (MSI−) primary tumours (n=3...
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Article
Open AccessOral capecitabine vs intravenous 5-fluorouracil and leucovorin: integrated efficacy data and novel analyses from two large, randomised, phase III trials
This study evaluates the efficacy of capecitabine using data from a large, well-characterised population of patients with metastatic colorectal cancer (mCRC) treated in two identically designed phase III studi...
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Article
Open AccessCarcinoma of the colon
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Article
Open AccessHepatocellular carcinoma
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Article
Open AccessCarcinoma of the oesophagus
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Open AccessCancer of the rectum
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Open AccessPrognostic factors for tumour response, progression-free survival and toxicity in metastatic colorectal cancer patients given irinotecan (CPT-11) as second-line chemotherapy after 5FU failure
Our purpose was to determine, in patients with metastatic colorectal carcinoma treated with irinotecan single-agent after 5-FU failure, the most significant predictive parameters for tumour response, progressi...
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Open AccessExtensive molecular screening for hereditary non-polyposis colorectal cancer
The genetic abnormalities underlying hereditary non-polyposis colorectal cancer (HNPCC) are germline mutations in one of five DNA mismatch repair genes or in the TGFβRII gene. The aim of our study was to evaluate...
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Open AccessTreatment of poorly differentiated neuroendocrine tumours with etoposide and cisplatin
The purpose of this study was to evaluate by a retrospective analysis of 53 patients the efficacy of chemotherapy combining etoposide and cisplatin in the treatment of neuroendocrine tumours. The regimen was a...
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Article
Absence of somatic alterations of the EB1 gene adenomatous polyposis coli-associated protein in human sporadic colorectal cancers
The human EB1 gene product was recently found, by a yeast two-hybrid screening, to be associated with the carboxy terminus of the APC (adenomatous polyposis coli) protein, the product of a tumour-suppressor ge...
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Article
Pharmacology and antitumour effects of intraportal pirarubicin on experimental liver metastases
Early liver metastases have a predominant portal blood supply. Intraportal (i.port.) vein administration of cytotoxics could theoretically achieve enhanced drug concentrations in tumour cells and be effective ...
