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Open AccessA tribute to Paul Kleihues, M.D. (1936–2022)
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Open AccessThe genomic and transcriptional landscape of primary central nervous system lymphoma
Primary lymphomas of the central nervous system (PCNSL) are mainly diffuse large B-cell lymphomas (DLBCLs) confined to the central nervous system (CNS). Molecular drivers of PCNSL have not been fully elucidate...
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The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary
The 2016 World Health Organization Classification of Tumors of the Central Nervous System is both a conceptual and practical advance over its 2007 predecessor. For the first time, the WHO classification of CNS...
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Article
Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein
Non-central nervous system hemangiopericytoma (HPC) and solitary fibrous tumor (SFT) are considered by pathologists as two variants of a single tumor entity now subsumed under the entity SFT. Recent detection ...
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Article
Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations
Meningiomas are among the most frequent intracranial tumors. The secretory variant of meningioma is characterized by glandular differentiation, formation of intracellular lumina and pseudopsammoma bodies, expr...
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Activating L265P mutations of the MYD88 gene are common in primary central nervous system lymphoma
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Mutations of CARD11 but not TNFAIP3 may activate the NF-κB pathway in primary CNS lymphoma
Primary CNS lymphoma (PCNSL), the intracerebral subgroup of diffuse large B cell lymphoma (DLBCL), shows evidence for aberrant activation of the nuclear factor (NF)-κB pathway. In order to identify potential a...
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Article
Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes
Ependymoblastoma (EBL) and embryonal tumor with abundant neuropil and true rosettes (ETANTR) are very aggressive embryonal neoplasms characterized by the presence of ependymoblastic multilayered rosettes typic...
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Open AccessArray-based DNA methylation profiling of primary lymphomas of the central nervous system
Although primary lymphomas of the central nervous system (PCNSL) and extracerebral diffuse large B-cell lymphoma (DLBCL) cannot be distinguished histologically, it is still a matter of debate whether PCNSL dif...
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Mechanisms of Disease: cancer stem cells—targeting the evil twin
Cancer stem cells often represent a minor, highly self-renewing population within the tumor mass and are thought to be the only cells required for both initiation and maintenance of disease. The biology of can...
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The 2007 WHO classification of tumours of the central nervous system
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Open AccessThe 2007 WHO Classification of Tumours of the Central Nervous System
The fourth edition of the World Health Organization (WHO) classification of tumours of the central nervous system, published in 2007, lists several new entities, including angiocentric glioma, papillary glione...
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Microtubule-associated protein-2 immunoreactivity: a useful tool in the differential diagnosis of low-grade neuroepithelial tumors
Complex and variable morphological phenotypes pose a major challenge to the histopathological classification of neuroepithelial tumors. This applies in particular for low-grade gliomas and glio-neuronal tumors...
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Analysis of chromosomal instability in focal cortical dysplasia of Taylor’s balloon cell type
Focal cortical dysplasias (FCD) represent a frequent finding in patients with chronic intractable epilepsy. Neuropathological hallmarks include localized dyslamination of the neocortex and neuronal heterotopia...
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An isomorphic subtype of long-term epilepsy-associated astrocytomas associated with benign prognosis
The semi-benign nature of diffuse astrocytomas is characterized by an increased risk for tumor recurrence and malignant transformation. In patients with intractable seizures, however, length of history and cli...
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Absence of simian virus 40 DNA sequences in primary central nervous system lymphoma in HIV-negative patients
Simian virus 40 (SV40) is known to induce primary brain tumors and lymphomas in animal models. Recently, it was also associated with the pathogenesis of human non-Hodgkin’s lymphomas. In the present study, we ...
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Article
Neurocytoma arising in the pelvis
Central neurocytoma represents a rare neoplasm of the central nervous system with advanced neurocytic and sometimes focal lipomatous differentiation, a low proliferative potential and a favorable prognosis dep...
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Analysis of the TP53 gene in laser-microdissected glioblastoma vasculature
Malignant transformation of human gliomas is accompanied by extensive proliferation of stromal blood vessels. Recent data suggest mesenchymal transdifferentiation of neoplastic cells in various human cancers, ...
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Article
Mutational and expression analysis of the reelin pathway components CDK5 and doublecortin in gangliogliomas
Gangliogliomas represent highly differentiated glioneuronal tumors frequently occurring in young patients with focal epilepsies. Dysplastic neurons are a neuropathological hallmark of this neoplasm. Here, we ...
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Human herpes virus-8 is not associated with primary central nervous system lymphoma in HIV-negative patients
Primary central nervous system lymphomas (PCNSL) are derived from germinal center B cells. Recent molecular studies indicate that the tumor cells or their precursors have experienced antigenic stimulation. At...
