Advances and Technical Standards in Neurosurgery
Volume 43
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Open AccessSuper-enhancer hijacking drives ectopic expression of hedgehog pathway ligands in meningiomas
Hedgehog signaling mediates embryologic development of the central nervous system and other tissues and is frequently hijacked by neoplasia to facilitate uncontrolled cellular proliferation. Meningiomas, the m...
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Open AccessControlled arterial hypotension during resection of cerebral arteriovenous malformations
Resection of cerebral arteriovenous malformations (AVM) is technically demanding because of size, eloquent location or diffuse nidus. Controlled arterial hypotension (CAH) could facilitate haemostasis. We perf...
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Open AccessMulti-scale image analysis and prediction of visual field defects after selective amygdalohippocampectomy
Selective amygdalohippocampectomy is an effective treatment for patients with therapy-refractory temporal lobe epilepsy but may cause visual field defect (VFD). Here, we aimed to describe tissue-specific pre- ...
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Open AccessPyramidal tract and alternate motor fibers complementarily mediate motor compensation in patients after hemispherotomy
Motor function after hemispheric lesions has been associated with the structural integrity of either the pyramidal tract (PT) or alternate motor fibers (aMF). In this study, we aimed to differentially characte...
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Open AccessMendelian randomization provides support for obesity as a risk factor for meningioma
Little is known about the causes of meningioma. Obesity and obesity-related traits have been reported in several epidemiological observational studies to be risk factors for meningioma. We performed an analysi...
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Open AccessCorrection: Author Correction: Integrated genomic analyses of de novo pathways underlying atypical meningiomas
Nature Communications 8: Article number: 14433 (2017) Published online 14 February 2017; Updated 20 April 2018 In this Article, a subset of the H3K27ac ChIP-seq data (15 benign meningiomas and 2 dura samples (...
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How I do it – selective amygdalohippocampectomy via a navigated temporobasal approach, when veins forbid elevation of the temporal lobe
Selective amygdalohippocampectomy is an effective treatment option for mesial temporal lobe epilepsy associated with hippocampal sclerosis.
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DNA methylation-based classification of central nervous system tumours
Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process ...
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Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors
Beatrice Melin, Richard Houlston, Melissa Bondy and colleagues report results of a large-scale genome-wide association study of glioma. They identify five new risk loci for glioblastoma and eight new risk loci...
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Open AccessIntegrated genomic analyses of de novo pathways underlying atypical meningiomas
Meningiomas are mostly benign brain tumours, with a potential for becoming atypical or malignant. On the basis of comprehensive genomic, transcriptomic and epigenomic analyses, we compared benign meningiomas t...
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Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas
Murat Günel and colleagues identify recurrent mutations in POLR2A, which encodes the catalytic subunit of RNA polymerase II, in a subset of meningiomas. They find that POLR2A-mutant tumors can be distinguished on...
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Vision after trans-sylvian or temporobasal selective amygdalohippocampectomy: a prospective randomised trial
Selective amygdalohippocampectomy (SAH) is an accepted surgical procedure for treatment of pharmacoresistant mesial temporal lobe epilepsy, but it may lead to postoperative visual field deficits (VFDs). Here w...
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Integrated genomic characterization of IDH1-mutant glioma malignant progression
Murat Günel and colleagues use an integrated genomic approach to analyze the malignant progression of IDH1-mutant gliomas. They observe nonlinear clonal expansion of the original tumors and identify oncogenic pat...
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Open AccessQuantifying the heritability of glioma using genome-wide complex trait analysis
Genome-wide association studies (GWAS) have successfully identified a number of common single-nucleotide polymorphisms (SNPs) influencing glioma risk. While these SNPs only explain a small proportion of the ge...
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Response to the future of the EANS neurosurgeons of Europe, unite!
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Open AccessGenome-wide association study identifies multiple susceptibility loci for glioma
Previous genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of glioma. To identify new glioma susceptibility loci, we conducted a meta-analysis o...
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Relevance of hippocampal integrity for memory outcome after surgical treatment of mesial temporal lobe epilepsy
Surgical treatment of unilateral mesial temporal lobe epilepsy (mTLE) particularly bears the risk of episodic memory decline. The present study investigates the role of the ipsilateral hippocampal integrity fo...
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Molecular classification of diffuse cerebral WHO grade II/III gliomas using genome- and transcriptome-wide profiling improves stratification of prognostically distinct patient groups
Cerebral gliomas of World Health Organization (WHO) grade II and III represent a major challenge in terms of histological classification and clinical management. Here, we asked whether large-scale genomic and...
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