19 Result(s)
within
José I Martín-Subero
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Open AccessTumorigenic role of Musashi-2 in aggressive mantle cell lymphoma
SOX11 overexpression has been associated with aggressive behavior of mantle cell lymphomas (MCL). SOX11 is overexpressed in embryonic and cancer stem cells (CSC) of some tumors. Although CSC have been isolated...
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Open AccessPublisher Correction: Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker
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Open AccessEpigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker
The molecular pathogenesis of T-cell large granular lymphocytic leukemia (T-LGLL), a mature T-cell leukemia arising commonly from T-cell receptor αβ-positive CD8+ memory cytotoxic T cells, is only partly understo...
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Molecular map of chronic lymphocytic leukemia and its impact on outcome
Recent advances in cancer characterization have consistently revealed marked heterogeneity, impeding the completion of integrated molecular and clinical maps for each malignancy. Here, we focus on chronic lymp...
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Open AccessWhole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features
The value of genome-wide over targeted driver analyses for predicting clinical outcomes of cancer patients is debated. Here, we report the whole-genome sequencing of 485 chronic lymphocytic leukemia patients e...
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Open AccessDetection of early seeding of Richter transformation in chronic lymphocytic leukemia
Richter transformation (RT) is a paradigmatic evolution of chronic lymphocytic leukemia (CLL) into a very aggressive large B cell lymphoma conferring a dismal prognosis. The mechanisms driving RT remain largel...
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Open AccessGene expression derived from alternative promoters improves prognostic stratification in multiple myeloma
Clinical and genetic risk factors are currently used in multiple myeloma (MM) to stratify patients and to design specific therapies. However, these systems do not capture the heterogeneity of the disease suppo...
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Open AccessMutational mechanisms sha** the coding and noncoding genome of germinal center derived B-cell lymphomas
B cells have the unique property to somatically alter their immunoglobulin (IG) genes by V(D)J recombination, somatic hypermutation (SHM) and class-switch recombination (CSR). Aberrant targeting of these mecha...
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Open AccessA lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions
LncRNAs have been shown to be direct players in chromatin regulation, but little is known about their role at active genomic loci. We investigate the role of lncRNAs in gene activation by profiling the RNA int...
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Open AccessInsight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics
Genome-wide association studies have provided evidence for inherited genetic predisposition to chronic lymphocytic leukemia (CLL). To gain insight into the mechanisms underlying CLL risk we analyze chromatin a...
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Retraction Note: NF-κB activation impairs somatic cell reprogramming in ageing
We, the authors, are retracting this Article due to issues that have come to our attention regarding data availability, data description and figure assembly. Specifically, original numerical data are not avail...
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Open AccessLong non-coding RNAs discriminate the stages and gene regulatory states of human humoral immune response
lncRNAs make up a majority of the human transcriptome and have key regulatory functions. Here we perform unbiased de novo annotation of transcripts expressed during the human humoral immune response to find 30...
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Open AccessDiscovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies
The indisputable role of epigenetics in cancer and the fact that epigenetic alterations can be reversed have favoured development of epigenetic drugs. In this study, we design and synthesize potent novel, sele...
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Non-coding recurrent mutations in chronic lymphocytic leukaemia
Chronic lymphocytic leukaemia (CLL) is a frequent disease in which the genetic alterations determining the clinicobiological behaviour are not fully understood. Here we describe a comprehensive evaluation of t...
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Non-coding recurrent mutations in chronic lymphocytic leukaemia
Chronic lymphocytic leukaemia (CLL) is a frequent disease in which the genetic alterations determining the clinicobiological behaviour are not fully understood. Here we describe a comprehensive evaluation of t...
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NF-κB activation impairs somatic cell reprogramming in ageing
Ageing constitutes a critical impediment to somatic cell reprogramming. We have explored the regulatory mechanisms that constitute age-associated barriers, through derivation of induced pluripotent stem cells ...
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Whole-genome fingerprint of the DNA methylome during human B cell differentiation
José Martín-Subero and colleagues report the whole-genome bisulfite sequencing of ten blood cell subpopulations representing the cellular stages during B cell differentiation. They find that early stages are c...
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Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia
José Martin-Subero and colleagues report whole-genome bisulfite sequencing and methylome analysis of two CLLs and three B-cell subpopulations using high-density microarrays on 139 CLLs. They identify widesprea...
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Open AccessArray-based DNA methylation profiling of primary lymphomas of the central nervous system
Although primary lymphomas of the central nervous system (PCNSL) and extracerebral diffuse large B-cell lymphoma (DLBCL) cannot be distinguished histologically, it is still a matter of debate whether PCNSL dif...
