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Open AccessA neural speech decoding framework leveraging deep learning and speech synthesis
Decoding human speech from neural signals is essential for brain–computer interface (BCI) technologies that aim to restore speech in populations with neurological deficits. However, it remains a highly challen...
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Open AccessAlignment of brain embeddings and artificial contextual embeddings in natural language points to common geometric patterns
Contextual embeddings, derived from deep language models (DLMs), provide a continuous vectorial representation of language. This embedding space differs fundamentally from the symbolic representations posited ...
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Open AccessSimilar brain proteomic signatures in Alzheimer’s disease and epilepsy
The prevalence of epilepsy is increased among Alzheimer’s Disease (AD) patients and cognitive impairment is common among people with epilepsy. Epilepsy and AD are linked but the shared pathophysiological chang...
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Open AccessClosed-loop brain stimulation augments fear extinction in male rats
Dysregulated fear reactions can result from maladaptive processing of trauma-related memories. In post-traumatic stress disorder (PTSD) and other psychiatric disorders, dysfunctional extinction learning preven...
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Open AccessThe role of superficial and deep layers in the generation of high frequency oscillations and interictal epileptiform discharges in the human cortex
Describing intracortical laminar organization of interictal epileptiform discharges (IED) and high frequency oscillations (HFOs), also known as ripples. Defining the frequency limits of slow and fast ripples. ...
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Open AccessExpanding genotype–phenotype correlations in FOXG1 syndrome: results from a patient registry
We refine the clinical spectrum of FOXG1 syndrome and expand genotype–phenotype correlations through evaluation of 122 individuals enrolled in an international patient registry.
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Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development
Malformations of cortical development (MCD) are neurological conditions involving focal disruptions of cortical architecture and cellular organization that arise during embryogenesis, largely from somatic mosa...
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Open AccessAcquired Pedophilia: international Delphi-method-based consensus guidelines
Idiopathic and acquired pedophilia are two different disorders with two different etiologies. However, the differential diagnosis is still very difficult, as the behavioral indicators used to discriminate the ...
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Publisher Correction: Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans
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Open AccessStructural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression
Epilepsy is associated with genetic risk factors and cortico-subcortical network alterations, but associations between neurobiological mechanisms and macroscale connectomics remain unclear. This multisite ENIG...
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Open AccessHeterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the develo** mouse cortex
HNRNPU encodes the heterogeneous nuclear ribonucleoprotein U, which participates in RNA splicing and chromatin organization. Microdeletions in the 1q44 locus encompassing HNRNPU and other genes and point mutation...
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Open AccessProteomic differences in hippocampus and cortex of sudden unexplained death in childhood
Sudden unexplained death in childhood (SUDC) is death of a child over 1 year of age that is unexplained after review of clinical history, circumstances of death, and complete autopsy with ancillary testing. Mu...
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Multiscale temporal integration organizes hierarchical computation in human auditory cortex
To derive meaning from sound, the brain must integrate information across many timescales. What computations underlie multiscale integration in human auditory cortex? Evidence suggests that auditory cortex ana...
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Open AccessShared computational principles for language processing in humans and deep language models
Departing from traditional linguistic models, advances in deep learning have resulted in a new type of predictive (autoregressive) deep language models (DLMs). Using a self-supervised next-word prediction task...
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Open AccessImagined speech can be decoded from low- and cross-frequency intracranial EEG features
Reconstructing intended speech from neural activity using brain-computer interfaces holds great promises for people with severe speech production deficits. While decoding overt speech has progressed, decoding ...
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Open AccessLong-term priors influence visual perception through recruitment of long-range feedback
Perception results from the interplay of sensory input and prior knowledge. Despite behavioral evidence that long-term priors powerfully shape perception, the neural mechanisms underlying these interactions re...
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Open AccessMoment-by-moment tracking of naturalistic learning and its underlying hippocampo-cortical interactions
Humans form lasting memories of stimuli that were only encountered once. This naturally occurs when listening to a story, however it remains unclear how and when memories are stored and retrieved during story-...
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Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans
Recent success in identifying gene-regulatory elements in the context of recombinant adeno-associated virus vectors has enabled cell-type-restricted gene expression. However, within the cerebral cortex these t...
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Autism risk in offspring can be assessed through quantification of male sperm mosaicism
De novo mutations arising on the paternal chromosome make the largest known contribution to autism risk, and correlate with paternal age at the time of conception. The recurrence risk for autism spectrum disor...
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Open AccessiEEG-BIDS, extending the Brain Imaging Data Structure specification to human intracranial electrophysiology
The Brain Imaging Data Structure (BIDS) is a community-driven specification for organizing neuroscience data and metadata with the aim to make datasets more transparent, reusable, and reproducible. Intracrania...
