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  1. No Access

    Article

    Cell-type-resolved mosaicism reveals clonal dynamics of the human forebrain

    Debate remains around the anatomical origins of specific brain cell subtypes and lineage relationships within the human forebrain1–7. Thus, direct observation in the mature human brain is critical for a complete ...

    Changuk Chung, **aoxu Yang, Robert F. Hevner, Katie Kennedy, Keng Ioi Vong… in Nature (2024)

  2. No Access

    Article

    Post-zygotic brain mosaicism as a result of partial reversion of pre-zygotic aneuploidy

    Brain somatic mosaicism is linked to several neurological disorders and is thought to arise post-zygotically. A study suggests that pre-zygotic aneuploidy followed by post-zygotic partial reversion leads to a ...

    Changuk Chung, **aoxu Yang, Joseph G. Gleeson in Nature Genetics (2023)

  3. No Access

    Article

    Control-independent mosaic single nucleotide variant detection with DeepMosaic

    Mosaic variants (MVs) reflect mutagenic processes during embryonic development and environmental exposure, accumulate with aging and underlie diseases such as cancer and autism. The detection of noncancer MVs ...

    **aoxu Yang, **n Xu, Martin W. Breuss, Danny Antaki, Laurel L. Ball… in Nature Biotechnology (2023)

  4. No Access

    Article

    Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development

    Malformations of cortical development (MCD) are neurological conditions involving focal disruptions of cortical architecture and cellular organization that arise during embryogenesis, largely from somatic mosa...

    Changuk Chung, **aoxu Yang, Taejeong Bae, Keng Ioi Vong, Swapnil Mittal… in Nature Genetics (2023)

  5. No Access

    Article

    Somatic mosaicism reveals clonal distributions of neocortical development

    The structure of the human neocortex underlies species-specific traits and reflects intricate developmental programs. Here we sought to reconstruct processes that occur during early development by sampling adu...

    Martin W. Breuss, **aoxu Yang, Johannes C. M. Schlachetzki, Danny Antaki… in Nature (2022)

  6. Article

    Open Access

    Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice

    NMDA receptor (NMDAR) and GABA neuronal dysfunctions are observed in animal models of autism spectrum disorders, but how these dysfunctions impair social cognition and behavior remains unclear. We report here ...

    Eunee Lee, Seungjoon Lee, Jae ** Shin, Woochul Choi… in Nature Communications (2021)

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  7. No Access

    Article

    Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice

    Autism spectrum disorders (ASDs) are four times more common in males than in females, but the underlying mechanisms are poorly understood. We characterized sexually dimorphic changes in mice carrying a heteroz...

    Hwa** Jung, Haram Park, Yeonsoo Choi, Hyo** Kang, Eunee Lee… in Nature Neuroscience (2018)

  8. Article

    Open Access

    Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activation

    Genetic aspects of autism spectrum disorders (ASDs) have recently been extensively explored, but environmental influences that affect ASDs have received considerably less attention. Zinc (Zn) is a nutritional ...

    Eun-Jae Lee, Hye** Lee, Tzyy-Nan Huang, Changuk Chung… in Nature Communications (2015)

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  9. No Access

    Article

    Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

    Mutations in SHANK2 have been associated with autism spectrum disorders in humans; here, Shank2 mutant mice are shown to exhibit autistic-like behaviours that can be improved by restoring decreased NMDA receptor ...

    Hyejung Won, Hye-Ryeon Lee, Heon Yung Gee, Won Mah, Jae-Ick Kim, Jiseok Lee… in Nature (2012)