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Article
Open AccessDifferential cortical layer engagement during seizure initiation and spread in humans
Despite decades of research, we still do not understand how spontaneous human seizures start and spread – especially at the level of neuronal microcircuits. In this study, we used laminar arrays of micro-elect...
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Article
Open AccessIntracortical mechanisms of single pulse electrical stimulation (SPES) evoked excitations and inhibitions in humans
Cortico-cortical evoked potentials (CCEPs) elicited by single-pulse electric stimulation (SPES) are widely used to assess effective connectivity between cortical areas and are also implemented in the presurgic...
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Article
Open AccessThe role of superficial and deep layers in the generation of high frequency oscillations and interictal epileptiform discharges in the human cortex
Describing intracortical laminar organization of interictal epileptiform discharges (IED) and high frequency oscillations (HFOs), also known as ripples. Defining the frequency limits of slow and fast ripples. ...
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Article
Open AccessThe sleep EEG envelope is a novel, neuronal firing-based human biomarker
Sleep EEG reflects voltage differences relative to a reference, while its spectrum reflects its composition of various frequencies. In contrast, the envelope of the sleep EEG reflects the instantaneous amplitu...
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Article
Open AccessBursting of excitatory cells is linked to interictal epileptic discharge generation in humans
Knowledge about the activity of single neurons is essential in understanding the mechanisms of synchrony generation, and particularly interesting if related to pathological conditions. The generation of interi...
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Article
Open AccessThe role of hybrid FDG-PET/MRI on decision-making in presurgical evaluation of drug-resistant epilepsy
When MRI fails to detect a potentially epileptogenic lesion, the chance of a favorable outcome after epilepsy surgery becomes significantly lower (from 60 to 90% to 20–65%). Hybrid FDG-PET/MRI may provide addi...
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Chapter and Conference Paper
Modeling Neuronal Firing in Epilepsy: Fitting Hawkes Processes to Single-Unit Activity
Forecasting seizures based on information extracted from neuronal firing has a great potential in controlling closed-loop neurostimulators. For the description of neuronal firing patterns we use self-exiting p...
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Article
Increased cortical involvement and synchronization during CAP A1 slow waves
Slow waves recorded with EEG in NREM sleep are indicative of the strength and spatial extent of synchronized firing in neuronal assemblies of the cerebral cortex. Slow waves often appear in the A1 part of the ...
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Article
Dabrafenib Therapy in 30 Patients with Melanoma Metastatic to the Brain: a Single-centre Controlled Retrospective Study in Hungary
Dabrafenib is a potent BRAF inhibitor, which showed intracranial tumor activity. The purpose of our retrospective analysis was to evaluate the efficacy of dabrafenib for patients with melanoma brain metastasis...
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Article
Open AccessSuperficial Slow Rhythms Integrate Cortical Processing in Humans
The neocortex is composed of six anatomically and physiologically specialized layers. It has been proposed that integration of activity across cortical areas is mediated anatomically by associative connections...
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Chapter
Time Series and Interactions: Data Processing in Epilepsy Research
Computational methods can have significant contribution to epilepsy research not only through modeling, but through data analysis as well. Vast amount of neural data has opened a new era of brain research, whe...
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Article
Competition between frontal lobe functions and implicit sequence learning: evidence from the long-term effects of alcohol
Implicit sequence learning is a fundamental mechanism that underlies the acquisition of motor, cognitive and social skills. The relationship between implicit learning and executive functions is still debated ...
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Article
Increased interictal spike activity associated with transient slow wave trains during non-rapid eye movement sleep
Non-rapid eye movement (NREM) sleep is characterized by recurring transient events (Cyclic Alternating Patterns, CAP), some of which consist of increased slow wave activity (A1 subtype). Such transient slow-wa...
