-
Article
Open AccessCoexistence of treatment-related MLL cleavage and rearrangement in a child with haemophagocytic lymphohistiocytosis
Treatment-related acute myeloid leukaemia (t-AML) is a serious complication of topoisomerase 2 inhibitor therapy and is characterised by the presence of mixed lineage leukaemia (MLL) rearrangement. By molecular t...
-
Article
Open AccessVitamin K and childhood cancer: a report from the United Kingdom Childhood Cancer Study
The relationship between neonatal vitamin K received by the intramuscular (i.m.) route and the development of leukaemia or other cancers was investigated as part of a national case–control study of childhood c...
-
Article
Open AccessAn infectious aetiology for childhood brain tumours? Evidence from space–time clustering and seasonality analyses
To investigate whether infections or other environmental exposures may be involved in the aetiology of childhood central nervous system tumours, we have analysed for space–time clustering and seasonality using...
-
Article
Open AccessImproved outcome in children with advanced stage B-cell non-Hodgkin's lymphoma (B-NHL): results of the United Kingdom Children Cancer Study Group (UKCCSG) 9002 protocol
From July 1990 to March 1996, 112 children with stage III or IV B-cell non-Hodgkin's lymphoma (B-NHL) with up to 70% FAB L3-type blasts (n= 42) in the bone marrow without central nervous system (CNS) disease were...
-
Article
Open AccessSpace–time clustering patterns in childhood leukaemia support a role for infection
Previous studies of space–time clustering in childhood leukaemia have produced equivocal and inconsistent results. To address this issue we have used Manchester Children’s Tumour Registry leukaemia data in spa...
-
Article
Open AccessReduced bone mineral density in young adults following cure of acute lympblastic leukaemia in childhood
Bone mineral density (BMD), serum osteocalcin and type I collagen C-telopeptide (ICTP) were assessed in a cohort of 31 (16 males) adults who had received cranial irradiation in childhood as part of their treat...
