52 Result(s)
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Nikolaos G. Papadopoulos
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Article
Open AccessExploring the Impact of Airway Microbiome on Asthma Morbidity: A Focus on the “Constructing a ‘Eubiosis Reinstatement Therapy’ for Asthma—CURE” Project
The asthma pandemic imposes a huge burden on patients and health systems in both developed and develo** countries. Despite available treatments, symptom control is generally suboptimal, and hospitalizations ...
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Article
Open AccessRespiratory eukaryotic virome expansion and bacteriophage deficiency characterize childhood asthma
Asthma development and exacerbation is linked to respiratory virus infections. There is limited information regarding the presence of viruses during non-exacerbation/infection periods. We investigated the naso...
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A Current Perspective of Allergic Asthma: From Mechanisms to Management
Asthma is a result of heterogenous, complex gene–environment interactions with variable clinical phenotypes, inflammation, and remodeling. It affects more than 330 million of people worldwide throughout their ...
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Open AccessIn Vitro Effects of 5-Lipoxygenase Pathway Inhibition on Rhinovirus-Associated Bronchial Epithelial Inflammation
The leukotriene pathway may be implicated in the induction of virus-induced inflammation. Respiratory epithelial cells may express low levels of 5-lipoxygenase (5-LO) and release leukotrienes (LTs) C4, D4, and...
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Article
Open AccessInternational severe asthma registry (ISAR): protocol for a global registry
Severe asthma exerts a disproportionately heavy burden on patients and health care. Due to the heterogeneity of the severe asthma population, many patients need to be evaluated to understand the clinical featu...
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Article
Open AccessEffect of nasal irrigation on allergic rhinitis control in children; complementarity between CARAT and MASK outcomes
Nasal irrigations (NI) are increasingly used as an over-the-counter adjunctive treatment for allergic rhinitis (AR), but clinical studies on their effectiveness are limited.
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Article
Correction to “ARIA guideline 2019: treatment of allergic rhinitis in the German health system”
Correction to:
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Open AccessARIA guideline 2019: treatment of allergic rhinitis in the German health system
The number of patients affected by allergies is increasing worldwide. The resulting allergic diseases are leading to significant costs for health care and social systems. Integrated care pathways are needed to...
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Article
ARIA-Leitlinie 2019: Behandlung der allergischen Rhinitis im deutschen Gesundheitssystem
Die Anzahl der von Allergien betroffenen Patienten nimmt weltweit zu. Hiermit gehen erhebliche Kosten für die Gesundheits- und Sozialsysteme durch allergische Erkrankungen einher. Integrierte Versorgungskonzep...
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Article
Open AccessTargeted deletion of NFAT-Interacting-Protein-(NIP) 45 resolves experimental asthma by inhibiting Innate Lymphoid Cells group 2 (ILC2)
Here we investigated the role of NFAT-interacting protein (NIP)-45, an Interleukin (IL)-4 inducing Transcription Factor, and its impact on the differentiation of Group 2 Innate -Lymphoid -Cells (ILC2s) in the ...
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Article
Open AccessThe safety and tolerability profile of bilastine for chronic urticaria in children
Urticaria is a condition defined by the development of wheals, angioedema or both. It is classified based on its duration as acute (≤ 6 weeks) or chronic (> 6 weeks). Chronic urticaria is less frequent than ac...
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Article
Open AccessThe REal Life EVidence AssessmeNt Tool (RELEVANT): development of a novel quality assurance asset to rate observational comparative effectiveness research studies
Evidence from observational comparative effectiveness research (CER) is ranked below that from randomized controlled trials in traditional evidence hierarchies. However, asthma observational CER studies repre...
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Article
Open AccessQuality standards in respiratory real-life effectiveness research: the REal Life EVidence AssessmeNt Tool (RELEVANT): report from the Respiratory Effectiveness Group—European Academy of Allergy and Clinical Immunology Task Force
A Task Force was commissioned jointly by the European Academy of Allergy and Clinical Immunology (EAACI) and the Respiratory Effectiveness Group (REG) to develop a quality assessment tool for real-life observa...
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Article
Open AccessPreDicta chip-based high resolution diagnosis of rhinovirus-induced wheeze
Rhinovirus (RV) infections are major triggers of acute exacerbations of severe respiratory diseases such as pre-school wheeze, asthma and chronic obstructive pulmonary disease (COPD). The occurrence of numerou...
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Open AccessThe importance of allergic disease in public health: an iCAALL statement
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Open AccessCritical view of anaphylaxis epidemiology: open questions and new perspectives
In contrast to the majority of allergic or hypersensitivity conditions, worldwide anaphylaxis epidemiological data remain sparse with low accuracy, which hampers comparable morbidity statistics. Data can diffe...
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Article
Open AccessCorrection: Corrigendum: IL-33/ST2 immune responses to respiratory bacteria in pediatric asthma
Scientific Reports 7: Article number: 43426; published online: 06 March 2017; updated: 24 August 2017. This Article contains an error in the Author Information section, where the following statement was omitte...
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Open AccessWAO International Scientific Conference (WISC 2016) Abstracts
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Open AccessAbstracts from the Food Allergy and Anaphylaxis Meeting 2016
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Open AccessIL-33/ST2 immune responses to respiratory bacteria in pediatric asthma
Here we investigated the relationship between local bacterial colonization and anti-bacterial immune responses in pre-school asthmatic and control children within the EU-wide study PreDicta. In this cohort of ...
