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  1. No Access

    Chapter

    Gene Silencing through RNA Interference

    A major focus of biology is determining the role that specific genes play within a cell. The ability to control gene expression is a powerful tool for biologists, and methods that facilitate the expression of ...

    David O. Azorsa, Spyro Mousses… in Peptide Nucleic Acids, Morpholinos and Rel… (2006)

  2. No Access

    Protocol

    Nucleic Acid Transfer Using Cationic Lipids

    The use of cationic lipids or cationic polymers to mediate the transfer of nucleic acids into mammalian cells has become a widely applied technology in recent years. The principal reasons for this have been th...

    Natasha J. Caplen in Gene Targeting Protocols (2000)

  3. No Access

    Chapter and Conference Paper

    Lipid Gene Trasfer, a Story of Simplicity and Complexity

    It is 10 years since the first description of the use of a positively charged lipid to deliver nucleic acids to mammalian cells (Feigner et al., 1987). In essence the methodology of liposome-mediated transfer of ...

    Natasha J. Caplen in Gene Therapy (1998)

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    Chapter and Conference Paper

    Gene Therapy for Cancer

    Cancer is a complex acquired disease that affects millions of individuals each year. Underlying the pathogenesis of cancer are a variety of molecular genetic abnormalities which can be inherited or environment...

    Susan A. Zullo, Natasha J. Caplen, R. Michael Blaese in Gene Therapy (1998)

  5. No Access

    Chapter and Conference Paper

    Lipid Gene Transfer and Clinical Gene Therapy

    There are several features of liposome-mediated DNA transfer that make it a viable delivery system for clinical gene therapy. 1) In contrast to viral delivery systems, contamination with exogenous protein or o...

    Natasha J. Caplen in Gene Therapy (1998)

  6. Article

    Book reviews

    An Introduction to Recombinant DNA in Medicine (2nd edn).

    Natasha J Caplen in Heredity (1997)

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    Article

    Complement C4 and heat shock protein 70 (HSP70) genotypes and type I diabetes mellitus

    Type I diabetes is strongly associated with the major histocompatibility complex (MHC) class II region (DR and DQ loci), and to a lesser extent the class III region (complement C4 loci). Restriction fragment leng...

    Natasha J. Caplen, Ashok Patel, Ann Millward, R. Duncan Campbell… in Immunogenetics (1990)