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Article
Open AccessRegulation of expression of two LY-6 family genes by intron retention and transcription induced chimerism
Regulation of the expression of particular genes can rely on mechanisms that are different from classical transcriptional and translational control. The LY6G5B and LY6G6D genes encode LY-6 domain proteins, whose ...
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Article
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
The MHC complex, occupying a sizeable section of human chromosome 6, is linked to almost all known autoimmune disorders. A new study uses a large data set from the Wellcome Trust Case Control Consortium to foc...
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Article
Novel NG36/G9a gene products encoded within the human and mouse MHC class III regions
Previous annotation of the Class III region of the human Major Histocompatibility Complex (MHC) depicts NG36 as an independent gene, which lies immediately centromeric to the G9a gene. However, data presented...
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Article
Susceptibility Locus for IgA Deficiency and Common Variable Immunodeficiency in the HLA-DR3, -B8, -A1 Haplotypes
A common genetic basis for IgA deficiency (IgAD) and common variable immunodeficiency (CVID) is suggested by their occurrence in members of the same family and the similarity of the underlying B cell different...
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Article
DNase I hypersensitivity map** and promoter polymorphism analysis of human C4
Human complement component C4 is encoded by two structurally distinct loci in the major histocompatibility complex (MHC) class III region. The two isotypes, C4A and C4B, differ at only four residues in the C4d...
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Article
Coding sequences and levels of expression of Hsc70t are identical in mice with different Orch-1 alleles
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Article
Localization of a new gene adjacent to the HSP70 genes in human and mouse MHCs
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Article
Genetic structure of the novel low-frequency haplotype HLA-B49,SC01,DR4 and its contribution to insulin-dependent diabetes susceptibility
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Article
Polymorphic analysis of the three MHC-linked HSP70 genes
Three genes encoding members of the M r 70 000 heat shock protein family (HSP70) are known to lie in the class III region of the human major histocompatibility complex. IN order to determine whether these genes o...
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Article
Fine map** of the crossover-sites in theC4-H-2D region ofH-2 recombinant mouse strains
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Article
Molecular analysis of the MHC class II region inDR4, DR7, andDR9 haplotypes
Within the class 11 region of the major histocompatibility complex (MHC) the amount of DNA in theDR-DQ interval has been shown to be haplotype dependent, with those carrying the DR4, DR7, and DR9 specificities ha...
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Article
Novel detection of restriction fragment length polymorphisms in the human major histocompatibility complex
Cosmid genomic DNA clones have been used as hybridization probes in genomic Southern blot analysis to define restriction fragment length polymorphisms (RFLPs) in the major histocompatibility complex (MHC). Usi...
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Article
Substitution of Ile-172 to Asn in the steroid 21-hydroxylase B (P450c21B) gene in a Finnish patient with the simple virilizing form of congenital adrenal hyperplasia
The steroid 21-hydroxylase enzyme (P450c21) is a member of the cytochrome P450 gene superfamily and is essential in the synthesis of cortisol and aldosterone. Defects in the P450c21B gene cause congenital adre...
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Article
Complement C4 and heat shock protein 70 (HSP70) genotypes and type I diabetes mellitus
Type I diabetes is strongly associated with the major histocompatibility complex (MHC) class II region (DR and DQ loci), and to a lesser extent the class III region (complement C4 loci). Restriction fragment leng...
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Article
Molecular analysis of the human MHC class I region in hereditary haemochromatosis
The unknown allele that predisposes to the development of haemochromatosis in man has been localized to the HLA class I region on the short arm of chromosome 6. We have utilized pulsed-field gel electrophoresi...
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Article
Structure and expression of the three MHC-linked HSP70 genes
A duplicated locus encoding the major heat shock-induced protein HSP70 is located in the major histocompatibility complex (MHC) class III region 92 kilobases (kb) telomeric to the C2 gene. Nucleotide sequence ana...
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Article
Characterization of the class III region in different MHC haplotypes by pulsed-field gel electrophoresis
The class III region of the human major histocompatibility complex (MHC) in sevenHLA haplotypes has been analyzed using pulsed-field gel electrophoresis (PFGE), restriction enzymes that cut genomic DNA infrequent...
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Article
Restriction fragment analysis of non-deleted complementC4 null genes suggests point mutations inC4A null alleles, but gene conversions inC4B null alleles
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Map** of the Human Major Histocompatibility Complex by Pulsed Field Gel Electrophoresis
Genetic analysis of recombinant HLA haplotypes in family studies has established that the class I loci (HLA-A, -B, and -C) lie telomeric to the class II (HLA-D) loci. Located between HLA-DR and HLA-B are the c...
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Chapter
Polymorphism of the HLA-Linked Steroid 21-Hydroxylase Genes
Deficiency of the cytochrome P-450 steroid 21-hydroxylase (21-OHase), which causes congenital adrenal hyperplasia (CAH), is a monogenic autosomal recessive disorder that is linked to HLA (1). There are two 21-...
