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Article
Reference values of diaphragmatic dimensions in healthy children aged 0–8 years
Diaphragmatic thickness (Tdi) and diaphragm thickening fraction (dTF) are widely used parameters in ultrasound studies of the diaphragm in mechanically ventilated children, but normal values for healthy childr...
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Article
COMFORTneo scale: a reliable and valid instrument to measure prolonged pain in neonates?
We studied the reliability and validity of the COMFORTneo scale, designed to measure neonatal prolonged pain.
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Article
Open AccessIntensive Care Medicine – Paediatric and Neonatal (ICM-PN): creating a journal to fill a gap and strengthen our domain
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Article
Postoperative breakthrough pain in paediatric cardiac surgery not reduced by increased morphine concentrations
Morphine is commonly used for postoperative analgesia in children. Here we studied the pharmacodynamics of morphine in children after cardiac surgery receiving protocolized morphine.
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Article
Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg/kg intravenous acetaminophen in very-preterm infants
Exposure to acetaminophen and its metabolites in very-preterm infants is partly unknown. We investigated the exposure to acetaminophen and its metabolites upon 10, 15, or 20 mg/kg intravenous acetaminophen in ...
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Article
Open AccessThermal quantitative sensory testing in healthy Dutch children and adolescents standardized test paradigm and Dutch reference values
Quantitative sensory testing (QST) is often used to measure children’s and adults’ detection- and pain thresholds in a quantitative manner. In children especially the Thermal Sensory Analyzer (TSA-II) is often...
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Article
Open AccessClinical recommendations for pain, sedation, withdrawal and delirium assessment in critically ill infants and children: an ESPNIC position statement for healthcare professionals
This position statement provides clinical recommendations for the assessment of pain, level of sedation, iatrogenic withdrawal syndrome and delirium in critically ill infants and children. Admission to a neona...
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Article
Open AccessLimited effects of intravenous paracetamol on patent ductus arteriosus in very low birth weight infants with contraindications for ibuprofen or after ibuprofen failure
Finding the optimal pharmacological treatment of a patent ductus arteriosus (PDA) in preterm neonates remains challenging. There is a growing interest in paracetamol as a new drug for PDA closure. In this pros...
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Article
Open AccessPain in Intellectually Disabled Children: Towards Evidence-Based Pharmacotherapy?
This critical opinion article deals with the challenges of finding the most effective pharmacotherapeutic options for the management of pain in intellectually disabled children and provides recommendations for...
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Article
Paediatric critical incident analysis: lessons learnt on analysis, recommendations and implementation
The objectives of this study were to identify causal and contributing factors of serious patient safety incidents in a paediatric university hospital, to report on ensuing recommendations and to assess the ext...
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Article
Optimal sedation in pediatric intensive care patients: a systematic review
Sedatives administered to critically ill children should be titrated to effect, because both under- and oversedation may have negative effects. We conducted a systematic review to examine reported incidences o...
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Article
Functional MRI pain studies in children? Yes, we (s)can!
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Article
Skin conductance peaks could result from changes in vital parameters unrelated to pain
Pain is usually assessed by the interpretation of behavior, which can be subjective. Therefore, there is an ongoing search for more objective methods. Performance of skin conductance measurement as a pain asse...
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Article
Open AccessReal-time registration of adverse events in Dutch hospitalized children in general pediatric units: first experiences
The objectives of this study are to describe the number and nature of adverse events occurring in general pediatric practice, to describe factors contributing to the occurrence of these adverse events, and to ...
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Article
Open AccessScreening pediatric delirium with an adapted version of the Sophia Observation withdrawal Symptoms scale (SOS)
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Article
Open AccessConstruction of the Sophia Observation withdrawal Symptoms-scale (SOS) for critically ill children
To construct a reliable and clinically practical instrument for monitoring opioids and benzodiazepine withdrawal symptoms in pediatric ICU patients.
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Article
Withdrawal symptoms in children after long-term administration of sedatives and/or analgesics: a literature review. “Assessment remains troublesome”
Prolonged administration of benzodiazepines and/or opioids to children in a pediatric intensive care unit (PICU) may induce physiological dependence and withdrawal symptoms.
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Article
Sedation and analgesia in the PICU: many questions remain
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Article
Postoperative pain in the neonate: age-related differences in morphine requirements and metabolism
To investigate age-related differences in morphine requirements and metabolism in full-term neonates.