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Article
Open AccessIntermittent intravenous paracetamol versus continuous morphine in infants undergoing cardiothoracic surgery: a multi-center randomized controlled trial
To determine whether intermittent intravenous (IV) paracetamol as primary analgesic would significantly reduce morphine consumption in children aged 0–3 years after cardiac surgery with cardiopulmonary bypass.
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Article
Open AccessMicrocirculatory Monitoring in Children with Congenital Heart Disease Before and After Cardiac Surgery
In this prospective observational study, we investigated whether congenital heart disease (CHD) affects the microcirculation and whether the microcirculation is altered following cardiac surgery with cardiopul...
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Article
Open AccessMaturation of Paracetamol Elimination Routes in Preterm Neonates Born Below 32 Weeks of Gestation
Despite being off-label, intravenous paracetamol (PCM) is increasingly used to control mild-to-moderate pain in preterm neonates. Here we aim to quantify the maturation of paracetamol elimination pathways in p...
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Article
Reference values of diaphragmatic dimensions in healthy children aged 0–8 years
Diaphragmatic thickness (Tdi) and diaphragm thickening fraction (dTF) are widely used parameters in ultrasound studies of the diaphragm in mechanically ventilated children, but normal values for healthy childr...
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Article
Open AccessDistinct roles for SOX2 and SOX21 in differentiation, distribution and maturation of pulmonary neuroendocrine cells
Pulmonary neuroendocrine (NE) cells represent a small population in the airway epithelium, but despite this, hyperplasia of NE cells is associated with several lung diseases, such as congenital diaphragmatic h...
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Article
Open AccessIntensive Care Medicine – Paediatric and Neonatal (ICM-PN): creating a journal to fill a gap and strengthen our domain
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Article
Open AccessValidation of disease-specific biomarkers for the early detection of bronchopulmonary dysplasia
To demonstrate and validate the improvement of current risk stratification for bronchopulmonary dysplasia (BPD) early after birth by plasma protein markers (sialic acid-binding Ig-like lectin 14 (SIGLEC-14), b...
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Article
Open AccessCorrection to: Pain and sedation management and monitoring in pediatric intensive care units across Europe: an ESPNIC survey
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Article
The development of descending serotonergic modulation of the spinal nociceptive network: a life span perspective
The nociceptive network, responsible for transmission of nociceptive signals that generate the pain experience, is not fully developed at birth. Descending serotonergic modulation of spinal nociception, an imp...
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Article
Open AccessPain and sedation management and monitoring in pediatric intensive care units across Europe: an ESPNIC survey
Management and monitoring of pain and sedation to reduce discomfort as well as side effects, such as over- and under-sedation, withdrawal syndrome and delirium, is an integral part of pediatric intensive care ...
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Article
Postoperative breakthrough pain in paediatric cardiac surgery not reduced by increased morphine concentrations
Morphine is commonly used for postoperative analgesia in children. Here we studied the pharmacodynamics of morphine in children after cardiac surgery receiving protocolized morphine.
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Article
Open AccessGenome wide DNA methylation analysis of alveolar capillary dysplasia lung tissue reveals aberrant methylation of genes involved in development including the FOXF1 locus
Alveolar capillary dysplasia with or without misalignment of the pulmonary veins (ACD/MPV) is a lethal congenital lung disorder associated with a variety of heterozygous genomic alterations in the FOXF1 gene or i...
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Article
Open AccessTowards Evidence-Based Weaning: a Mechanism-Based Pharmacometric Model to Characterize Iatrogenic Withdrawal Syndrome in Critically Ill Children
For the management of iatrogenic withdrawal syndrome (IWS) in children, a quantitative understanding of the dynamics of IWS of commonly used opioids and sedatives is lacking. Here, we introduce a new mechanism...
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Article
Methadone effectively attenuates acute and long-term consequences of neonatal repetitive procedural pain in a rat model
Painful procedures in early life cause acute pain and can alter pain processing at a spinal level lasting into adulthood. Current methods of analgesia seem unable to prevent both acute and long-term hypersensi...
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Article
Fast detection of FOXF1 variants in patients with alveolar capillary dysplasia with misalignment of pulmonary veins using targeted sequencing
Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is a lethal congenital lung disorder associated with heterozygous variants in the FOXF1 gene or its regulatory region. Patients with ACD...
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Article
Open AccessRectal Omeprazole in Infants With Gastroesophageal Reflux Disease: A Randomized Pilot Trial
Omeprazole is a proton pump inhibitor that is used in acid suppression therapy in infants. Infants cannot swallow the oral tablets or capsules. Since, infants require a non-standard dose of omeprazole, the gra...
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Article
Open AccessIntegration of Placental Transfer in a Fetal–Maternal Physiologically Based Pharmacokinetic Model to Characterize Acetaminophen Exposure and Metabolic Clearance in the Fetus
Although acetaminophen is frequently used during pregnancy, little is known about fetal acetaminophen pharmacokinetics. Acetaminophen safety evaluation has typically focused on hepatotoxicity, while other even...
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Article
Cervical ribs and other abnormalities of the vertebral pattern in children with esophageal atresia and anorectal malformations
In mammals the vertebral column has a constant pattern, particularly in the cervical region, which is likely the result of stabilizing selection. The prevalence of cervical ribs and extended vertebral pattern ...
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Article
Open AccessPharmacokinetic modeling of intravenous sildenafil in newborns with congenital diaphragmatic hernia
We developed a pharmacokinetic model of intravenous sildenafil in newborns with congenital diaphragmatic hernia (CDH) to achieve a target plasma concentration of over 50 μg/l.
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Narcotic-Sparing Approaches and the Shift Toward Paracetamol in Neonatal Intensive Care
Effective analgesia in neonates is relevant not only because of ethical aspects or empathy, but it is a crucial and integral part of medical and nursing care. However, there is also emerging evidence – althoug...
