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Article
Correction to: Perfluorooctanoic acid exposure and its neurodegenerative consequences in C57BL6/J mice
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Article
Perfluorooctanoic acid exposure and its neurodegenerative consequences in C57BL6/J mice
Perfluorooctanoic acid (PFOA) is a member of Per- and polyfluoroalkyl substances (PFASs), an industrial pollutant that has been produced for decades and widely used in various industries. Accumulation of this ...
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Article
Apamin as a BBB Shuttle and Its Effects on T Cell Population During the Experimental Autoimmune Encephalomyelitis-Induced Model of Multiple Sclerosis
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system presented by autoimmune manifestations. This study aimed at investigating the effects of apamin administration on the ac...
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Article
Analysis of platelet-derived growth factor receptor A and oligodendrocyte transcription factor 2 markers following Hydroxychloroquine administration in animal induced multiple sclerosis model
It has been shown that following demyelination, Oligodendrocyte Progenitor Cells (OPCs) migrate to the lesion site and begin to proliferate, and differentiate. This study aimed to investigate the effects of Hy...
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Article
Bee Venom–Derived BBB Shuttle and its Correlation with Oligodendrocyte Proliferation Markers in Mice Model of Multiple Sclerosis
Multiple sclerosis is a chronic demyelinating disease with a functional disturbance in the immune system and axonal damages. It was shown that Apamin as a blood–brain barrier shuttle acts as a Ca2+ activated K...
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Article
Open AccessStudy of the probable genotoxic effects of Zolone (Phosalone) exposure in mice bone marrow derived cells
Approximately, 2 million tonnes of pesticides are utilized annually worldwide. Phosalone (Pln), an organophosphorus pesticide, acts as an insecticide and acaricide to control pests of crops such as nuts, citru...
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Article
Hydroxychloroquine effects on miR-155-3p and miR-219 expression changes in animal model of multiple sclerosis
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system which causes chronic demyelination. Hydroxychloroquine (HCQ) possess immunosuppressive and anti-inflammatory properties. ...
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Article
Apamin administration impact on miR-219 and miR-155-3p expression in cuprizone induced multiple sclerosis model
Multiple sclerosis (MS) is a chronic debilitating disease that attacks the central nervous system. This study aims to investigate miR-219 and miR-155-3p expression levels involved in the myelination process fo...
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Article
Mechanisms and pathogenesis underlying environmental chemical-induced necroptosis
Necroptosis is a regulated cell death that is governed by mixed lineage kinase domain-like, receptor-interacting serine-threonine kinase 3 and commonly displays with necrosis morphological characteristics. Thi...
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Article
Is There Any Relevance Between Serum Heavy Metal Concentration and BBB Leakage in Multiple Sclerosis Patients?
Sharp increase in multiple sclerosis (MS) incidence rate has been observed in Iranian people. In addition, it has been suggested that increased S100B level may be useful as an indicative factor of blood-brain ...
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Article
Chronic Oral Arsenic Exposure and Its Correlation with Serum S100B Concentration
Arsenic is one of the most important environmental pollutants especially in drinking water. The S100B protein is presented as a sensitive biomarker for assessment of the blood-brain barrier integrity previousl...
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Article
Correlation between heavy metal exposure and GSTM1 polymorphism in Iranian multiple sclerosis patients
Multiple sclerosis (MS) is an immune-mediated chronic inflammatory disease of the central nervous system. Various exposures to heavy metals can lead to toxicity and oxidative stress. While glutathione-S-transf...
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Article
Open AccessEffects of phloretin on oxidative and inflammatory reaction in rat model of cecal ligation and puncture induced sepsis
Sepsis is a debilitating systemic disease and described as a severe and irregular systemic inflammatory reaction syndrome (SIRS) against infection. We employed CLP (Cecal Ligation and Puncture) model in rats t...
