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Open AccessRegion-specific remodeling of the enteric nervous system and enteroendocrine cells in the colon of spinal cord injury patients
Patients with spinal cord injury (SCI) suffer from major bowel dysfunction, whose exact pathophysiology, particularly the involvement of the enteric nervous system or epithelial dysfunction is poorly understoo...
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Article
Open AccessSacral neuromodulation for refractory ulcerative colitis: safety and efficacy in a prospective observational series of eight patients
Ulcerative colitis (UC) treatment is mainly based on immunosuppressive therapy. As anti-inflammatory effects of sacral neuromodulation (SNM) have been previously reported in animal models, we conducted a pilot...
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Article
Open AccessVisualizing enteric nervous system activity through dye-free dynamic full-field optical coherence tomography
Major advances have been achieved in imaging technologies but most methodological approaches currently used to study the enteric neuronal functions rely on exogenous contrast dyes that can interfere with cellu...
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Article
Gastrointestinal mucosal biopsies in Parkinson’s disease: beyond alpha-synuclein detection
Alpha-synuclein deposits, the pathological hallmarks of Parkinson’s disease, are consistently found in the gastrointestinal tract of parkinsonian subjects. These observations have raised the potential that end...
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Open AccessAltered epithelial barrier functions in the colon of patients with spina bifida
Our objectives were to better characterize the colorectal function of patients with Spina Bifida (SB). Patients with SB and healthy volunteers (HVs) completed prospectively a standardized questionnaire, clinic...
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Article
LRRK2 is reduced in Parkinson’s disease gut
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Open AccessLimited Impact of 6-Mercaptopurine on Inflammation-Induced Chemokines Expression Profile in Primary Cultures of Enteric Nervous System
Increasing evidences indicate that the enteric nervous system (ENS) and enteric glial cells (EGC) play important regulatory roles in intestinal inflammation. Mercaptopurine (6-MP) is a cytostatic compound clin...
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Article
Open AccessMiBiOmics: an interactive web application for multi-omics data exploration and integration
Multi-omics experimental approaches are becoming common practice in biological and medical sciences underlining the need to design new integrative techniques and applications to enable the multi-scale characte...
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Article
Open AccessAnalysis of enteric nervous system and intestinal epithelial barrier to predict complications in Hirschsprung’s disease
In Hirschsprung’s disease (HSCR), postoperative course remains unpredictable. Our aim was to define predictive factors of the main postoperative complications: obstructive symptoms (OS) and Hirschsprung-associ...
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Open AccessSemaphorin 3A controls enteric neuron connectivity and is inversely associated with synapsin 1 expression in Hirschsprung disease
Most of the gut functions are controlled by the enteric nervous system (ENS), a complex network of enteric neurons located throughout the wall of the gastrointestinal tract. The formation of ENS connectivity d...
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Is Parkinson’s disease a chronic low-grade inflammatory bowel disease?
While the pathogenesis of Parkinson’s disease is not fully understood, there is increasing evidence that inflammatory responses in the brain are implicated in both disease initiation and progression. The infla...
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Open AccessImpact of pemetrexed chemotherapy on the gut microbiota and intestinal inflammation of patient-lung-derived tumor xenograft (PDX) mouse models
Chemotherapy remains the gold standard for advanced cancer. Pemetrexed, a chemotherapeutic agent used in non-small cell lung cancer, can induce significant side effects in patients. Although microbiota’s role ...
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Enteric alpha-synuclein expression is increased in Crohn’s disease
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Open AccessCharacterisation of tau in the human and rodent enteric nervous system under physiological conditions and in tauopathy
Tau is normally a highly soluble phosphoprotein found predominantly in neurons. Six different isoforms of tau are expressed in the adult human CNS. Under pathological conditions, phosphorylated tau aggregates ...
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Article
Crohn’s and Parkinson disease: is LRRK2 lurking around the corner?
Exome sequencing of patients with Crohn’s disease (CD) of Ashkenazi Jewish descent and genoty** of large case–control cohorts has identified new CD risk and protective variants of LRRK2, the most common genetic...
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Anti-inflammatory Effects of Enhanced Recovery Programs on Early-Stage Colorectal Cancer Surgery
Postoperative ileus (POI) is observed in 20–30% of patients undergoing colorectal cancer surgery, despite enhanced recovery programs (ERPs). Cyclooxygenase (COX)-2 is identified as a key enzyme in POI, but oth...
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Heterogeneous pattern of autonomic dysfunction in Parkinson’s disease
Dysautonomic symptoms are frequent non-motor complaints in patients with Parkinson’s disease. Numerous neuropathological studies have shown that Lewy bodies and neurites, the pathological hallmarks of Parkinso...
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Article
Does Parkinson’s disease start in the gut?
Parkinson’s disease (PD) is pathologically characterized by the presence of intraneuronal inclusions, termed Lewy bodies and Lewy neurites, whose main component is alpha-synuclein. Based on the topographic dis...
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Article
Sleeve Gastrectomy Alters Intestinal Permeability in Diet-Induced Obese Mice
Increased lipopolysaccharide (LPS) translocation due to altered intestinal permeability has been suggested as a mechanism for obesity-associated insulin resistance. The goal of this study was to assess the eff...
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Open AccessAbstracts from the Food Allergy and Anaphylaxis Meeting 2016
