7 Result(s)
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Laurène Leclair-Visonneau
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Article
Gastrointestinal mucosal biopsies in Parkinson’s disease: beyond alpha-synuclein detection
Alpha-synuclein deposits, the pathological hallmarks of Parkinson’s disease, are consistently found in the gastrointestinal tract of parkinsonian subjects. These observations have raised the potential that end...
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Article
Is Parkinson’s disease a chronic low-grade inflammatory bowel disease?
While the pathogenesis of Parkinson’s disease is not fully understood, there is increasing evidence that inflammatory responses in the brain are implicated in both disease initiation and progression. The infla...
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Article
Heterogeneous pattern of autonomic dysfunction in Parkinson’s disease
Dysautonomic symptoms are frequent non-motor complaints in patients with Parkinson’s disease. Numerous neuropathological studies have shown that Lewy bodies and neurites, the pathological hallmarks of Parkinso...
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Article
Does Parkinson’s disease start in the gut?
Parkinson’s disease (PD) is pathologically characterized by the presence of intraneuronal inclusions, termed Lewy bodies and Lewy neurites, whose main component is alpha-synuclein. Based on the topographic dis...
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Article
Open AccessErratum to: An exploratory randomised double-blind and placebo-controlled phase 2 study of a combination of baclofen, naltrexone and sorbitol (PXT3003) in patients with Charcot-Marie-Tooth disease type 1A
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Article
Open AccessStructural alterations of the intestinal epithelial barrier in Parkinson’s disease
Functional and morphological alterations of the intestinal epithelial barrier (IEB) have been consistently reported in digestive disorders such as irritable bowel syndrome and inflammatory bowel disease. There...
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Article
Open AccessAn exploratory randomised double-blind and placebo-controlled phase 2 study of a combination of baclofen, naltrexone and sorbitol (PXT3003) in patients with Charcot-Marie-Tooth disease type 1A
Charcot-Marie-Tooth type 1A disease (CMT1A) is a rare orphan inherited neuropathy caused by an autosomal dominant duplication of a gene encoding for the structural myelin protein PMP22, which induces abnormal...
