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Article
Open AccessCharacterisation of tau in the human and rodent enteric nervous system under physiological conditions and in tauopathy
Tau is normally a highly soluble phosphoprotein found predominantly in neurons. Six different isoforms of tau are expressed in the adult human CNS. Under pathological conditions, phosphorylated tau aggregates ...
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Article
Open AccessMembrane association and release of wild-type and pathological tau from organotypic brain slice cultures
The spatiotemporal transmission of pathological tau in the brain is characteristic of Alzheimer’s disease. Release of both soluble and abnormal tau species from healthy neurons is increased upon stimulation of...
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Article
Open AccessUpregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain
Alterations in calcium homeostasis are widely reported to contribute to synaptic degeneration and neuronal loss in Alzheimer’s disease. Elevated cytosolic calcium concentrations lead to activation of the calci...
