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Open AccessDynamical states, possibilities and propagation of stress signal
The stress driven dynamics of Notch-Wnt-p53 cross-talk is subjected to a few possible dynamical states governed by simple fractal rules, and allowed to decide its own fate by choosing one of these states which...
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Article
Potential entry inhibitors of the envelope protein (E2) of Chikungunya virus: in silico structural modeling, docking and molecular dynamic studies
Chikungunya fever is an arboviral infection caused by the Chikungunya virus (CHIKV) and is transmitted by Aedes mosquito. The envelope protein (E2) of Chikungunya virus is involved in attachment of virion with th...
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Pharmacokinetic and Molecular Docking Studies of Plant-Derived Natural Compounds to Exploring Potential Anti-Alzheimer Activity
Alzheimer disease (AD) is the leading cause of dementia and accounts for 60–80% cases. Two main factors called β-amyloid (Aβ) plaques and tangles are prime suspects in damaging and killing nerve cells. However...
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Open AccessAssessment of the key regulatory genes and their Interologs for Turner Syndrome employing network approach
Turner Syndrome (TS) is a condition where several genes are affected but the molecular mechanism remains unknown. Identifying the genes that regulate the TS network is one of the main challenges in understandi...
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Open AccessIdentification of key regulators in prostate cancer from gene expression datasets of patients
Identification of key regulators and regulatory pathways is an important step in the discovery of genes involved in cancer. Here, we propose a method to identify key regulators in prostate cancer (PCa) from a ...
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Open AccessMethodology of predicting novel key regulators in ovarian cancer network: a network theoretical approach
Identification of key regulator/s in ovarian cancer (OC) network is important for potential drug target and prevention from this cancer. This study proposes a method to identify the key regulators of this netw...
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Open AccessTransition and identification of pathological states in p53 dynamics for therapeutic intervention
We study a minimal model of the stress-driven p53 regulatory network that includes competition between active and mutant forms of the tumor-suppressor gene p53. Depending on the nature and level of the externa...
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Article
Brain Disease Network Analysis to Elucidate the Neurological Manifestations of COVID-19
Although COVID-19 largely causes respiratory complications, it can also lead to various extrapulmonary manifestations resulting in higher mortality and these comorbidities are posing a challenge to the health ...
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Article
Noise and delay can shape distribution functions in stochastic reaction dynamics
Noise can drive the dynamics of stochastic systems to different important states. Delay is another significant parameter that may impart non-Markovian behavior in the system dynamics. The interplay of noise an...
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Open AccessIdentification of key regulators in Sarcoidosis through multidimensional systems biological approach
Sarcoidosis is a multi-organ disorder where immunology, genetic and environmental factors play a key role in causing Sarcoidosis, but its molecular mechanism remains unclear. Identification of its genetics pro...
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Open AccessElevated Vulnerability of Chronic Leukemia Patients to COVID-19 Infection: A Systems Biology Approach
Emerging evidence has shown that SARS-CoV-2 may affect the circulatory system in addition to the human respiratory system. However, no study has indicated whether patients with leukemia have a greater likeliho...
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Network pharmacology and bioinformatics approach reveals the therapeutic mechanism of action of curcumin in Alzheimer disease
Curcumin is a natural anti-inflammatory and antioxidant substance which plays a major role in reducing the amyloid plaques formation, which is the major cause of Alzheimer’s disease (AD). Consequently, a metho...
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SARS CoV-2 spike protein variants exploit DC-SIGN/DC-SIGNR receptor for evolution and severity: an in-silico insight
The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is related with the COVID-19 pandemic. Recent spike protein variations have had an effect on the transmission of the virus. In addition to ACE-2...
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Comprehensive multiomics and in silico approach uncovers prognostic, immunological, and therapeutic roles of ANLN in lung adenocarcinoma
The anillin actin-binding protein (ANLN) is immensely overexpressed in cancers, including lung cancer (LC). Phytocompounds have gained interest due to their broader potential and reduced unwanted effects. Screeni...
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Correction to: Comprehensive multiomics and in silico approach uncovers prognostic, immunological, and therapeutic roles of ANLN in lung adenocarcinoma
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Investigating the link between miR-34a-5p and TLR6 signaling in sepsis-induced ARDS
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are lung complications diagnosed by impaired gaseous exchanges leading to mortality. From the diverse etiologies, sepsis is a prominent contri...
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Open AccessA bioinformatics approach to elucidate conserved genes and pathways in C. elegans as an animal model for cardiovascular research
Cardiovascular disease (CVD) is a collective term for disorders of the heart and blood vessels. The molecular events and biochemical pathways associated with CVD are difficult to study in clinical settings on ...
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A Comprehensive Pilot Study to Elucidate the Distinct Gut Microbial Composition and Its Functional Significance in Cardio-Metabolic Disease
Cardio-metabolic disease is a significant global health challenge with increasing prevalence. Recent research underscores the disruption of gut microbial balance as a key factor in disease susceptibility. We a...
